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LRRFIP1 LRR binding FLII interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 9208, updated on 27-Nov-2024

Summary

Official Symbol
LRRFIP1provided by HGNC
Official Full Name
LRR binding FLII interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:6702
See related
Ensembl:ENSG00000124831 MIM:603256; AllianceGenome:HGNC:6702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung (RPKM 14.3), bone marrow (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

See LRRFIP1 in Genome Data Viewer
Location:
2q37.3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (237627587..237781643)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (238117567..238271644)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (238536230..238690286)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238483169-238483868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238485267-238485965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238490210-238490844 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238503899-238504617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238504725-238505226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238512736-238513239 Neighboring gene RAB17, member RAS oncogene family Neighboring gene RAB17 divergent transcript Neighboring gene VISTA enhancer hs1945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238539637-238540136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238540139-238540700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238558724-238559224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238559225-238559725 Neighboring gene NANOG hESC enhancer GRCh37_chr2:238571326-238571867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238572854-238573422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238581723-238582348 Neighboring gene Sharpr-MPRA regulatory region 636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238583717-238584263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238595001-238595502 Neighboring gene uncharacterized LOC124906128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238595503-238596002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238599723-238600598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238611455-238612335 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:238612336-238613215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238626179-238626695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238630967-238631468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238631469-238631968 Neighboring gene Sharpr-MPRA regulatory region 7631 Neighboring gene Sharpr-MPRA regulatory region 7730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238653055-238653580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17376 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:238671072-238671284 Neighboring gene RNA binding motif protein 44 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238766078-238766866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:238766867-238767653 Neighboring gene small nucleolar RNA SNORD55/SNORD39 Neighboring gene receptor activity modifying protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10063, MGC10947, MGC119738, MGC119739

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
leucine-rich repeat flightless-interacting protein 1
Names
GC-binding factor 2
LRR FLII-interacting protein 1
NEDD8-conjugating enzyme
TAR RNA-interacting protein
leucine rich repeat (in FLII) interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137550.2NP_001131022.1  leucine-rich repeat flightless-interacting protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' and 3' UTRs, and has multiple coding region differences, compared to variant 3. The resulting isoform (1) has a longer and distinct N-terminus, three additional internal segments and a shorter and distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AA975133, AC012076, AF115510, BG699031
    Consensus CDS
    CCDS46551.1
    UniProtKB/Swiss-Prot
    Q32MZ4
    Related
    ENSP00000310109.9, ENST00000308482.14
    Conserved Domains (2) summary
    COG1340
    Location:362632
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cl12057
    Location:362439
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  2. NM_001137551.2NP_001131023.1  leucine-rich repeat flightless-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001131023.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three internal coding exons and the 3' terminal exon, but has several additional coding exons near to an alternate 3' terminal exon, compared to variant 3. The resulting isoform (2) lacks two internal segments and has a shorter and distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AA975133, AC012076, AK298270, BE390005
    UniProtKB/TrEMBL
    B4DPC0
    Conserved Domains (2) summary
    pfam09738
    Location:42319
    LRRFIP; LRRFIP family
    pfam11932
    Location:335394
    DUF3450; Protein of unknown function (DUF3450)
  3. NM_001137552.2NP_001131024.1  leucine-rich repeat flightless-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001131024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC012076, BC108914, BE390005, BU685896
    Consensus CDS
    CCDS46552.1
    UniProtKB/Swiss-Prot
    E9PGZ2, O75766, O75799, Q32MZ4, Q32MZ5, Q53T49, Q6PKG2, Q9Y607
    Related
    ENSP00000375857.4, ENST00000392000.4
    Conserved Domains (1) summary
    pfam09738
    Location:42314
    DUF2051; Double stranded RNA binding protein (DUF2051)
  4. NM_001137553.2NP_001131025.1  leucine-rich repeat flightless-interacting protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001131025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three internal exons in the coding region, but maintains the reading frame, compared to variant 3. The resulting isoform (5) lacks two internal segments, compared to isoform 3.
    Source sequence(s)
    AC012076, BC108913, BE390005, BU685896
    Consensus CDS
    CCDS46553.1
    UniProtKB/TrEMBL
    A0A0F7NGI8
    Related
    ENSP00000289175.6, ENST00000289175.10
    Conserved Domains (1) summary
    pfam09738
    Location:42258
    DUF2051; Double stranded RNA binding protein (DUF2051)
  5. NM_004735.4NP_004726.2  leucine-rich repeat flightless-interacting protein 1 isoform 4

    See identical proteins and their annotated locations for NP_004726.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 3. The resulting isoform (4) lacks an internal segment, compared to isoform 3.
    Source sequence(s)
    AC012076, AJ223075, AK307485, BE390005, BU685896
    Consensus CDS
    CCDS2521.1
    UniProtKB/Swiss-Prot
    Q32MZ4
    Related
    ENSP00000244815.5, ENST00000244815.9
    Conserved Domains (1) summary
    pfam09738
    Location:42290
    DUF2051; Double stranded RNA binding protein (DUF2051)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    237627587..237781643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005257.3XP_016860746.1  leucine-rich repeat flightless-interacting protein 1 isoform X34

  2. XM_017005260.3XP_016860749.1  leucine-rich repeat flightless-interacting protein 1 isoform X35

  3. XM_017005262.3XP_016860751.1  leucine-rich repeat flightless-interacting protein 1 isoform X36

  4. XM_005246141.5XP_005246198.1  leucine-rich repeat flightless-interacting protein 1 isoform X42

    Conserved Domains (1) summary
    pfam09738
    Location:52352
    DUF2051; Double stranded RNA binding protein (DUF2051)
  5. XM_017005263.3XP_016860752.1  leucine-rich repeat flightless-interacting protein 1 isoform X38

    UniProtKB/TrEMBL
    A0A8V8TLX7
  6. XM_005246142.3XP_005246199.1  leucine-rich repeat flightless-interacting protein 1 isoform X45

    Conserved Domains (1) summary
    pfam09738
    Location:52328
    DUF2051; Double stranded RNA binding protein (DUF2051)
  7. XM_047446293.1XP_047302249.1  leucine-rich repeat flightless-interacting protein 1 isoform X1

  8. XM_047446295.1XP_047302251.1  leucine-rich repeat flightless-interacting protein 1 isoform X3

  9. XM_047446303.1XP_047302259.1  leucine-rich repeat flightless-interacting protein 1 isoform X11

  10. XM_047446297.1XP_047302253.1  leucine-rich repeat flightless-interacting protein 1 isoform X5

  11. XM_047446306.1XP_047302262.1  leucine-rich repeat flightless-interacting protein 1 isoform X14

  12. XM_047446294.1XP_047302250.1  leucine-rich repeat flightless-interacting protein 1 isoform X2

  13. XM_047446296.1XP_047302252.1  leucine-rich repeat flightless-interacting protein 1 isoform X4

  14. XM_047446299.1XP_047302255.1  leucine-rich repeat flightless-interacting protein 1 isoform X7

  15. XM_047446312.1XP_047302268.1  leucine-rich repeat flightless-interacting protein 1 isoform X20

  16. XM_047446298.1XP_047302254.1  leucine-rich repeat flightless-interacting protein 1 isoform X6

  17. XM_047446309.1XP_047302265.1  leucine-rich repeat flightless-interacting protein 1 isoform X17

  18. XM_047446302.1XP_047302258.1  leucine-rich repeat flightless-interacting protein 1 isoform X10

  19. XM_047446317.1XP_047302273.1  leucine-rich repeat flightless-interacting protein 1 isoform X25

  20. XM_047446310.1XP_047302266.1  leucine-rich repeat flightless-interacting protein 1 isoform X18

  21. XM_047446318.1XP_047302274.1  leucine-rich repeat flightless-interacting protein 1 isoform X26

  22. XM_047446301.1XP_047302257.1  leucine-rich repeat flightless-interacting protein 1 isoform X9

  23. XM_047446316.1XP_047302272.1  leucine-rich repeat flightless-interacting protein 1 isoform X24

  24. XM_047446322.1XP_047302278.1  leucine-rich repeat flightless-interacting protein 1 isoform X30

  25. XM_047446307.1XP_047302263.1  leucine-rich repeat flightless-interacting protein 1 isoform X15

  26. XM_047446323.1XP_047302279.1  leucine-rich repeat flightless-interacting protein 1 isoform X31

  27. XM_047446315.1XP_047302271.1  leucine-rich repeat flightless-interacting protein 1 isoform X23

  28. XM_047446325.1XP_047302281.1  leucine-rich repeat flightless-interacting protein 1 isoform X33

  29. XM_047446326.1XP_047302282.1  leucine-rich repeat flightless-interacting protein 1 isoform X37

  30. XM_047446328.1XP_047302284.1  leucine-rich repeat flightless-interacting protein 1 isoform X40

  31. XM_047446329.1XP_047302285.1  leucine-rich repeat flightless-interacting protein 1 isoform X41

  32. XM_047446327.1XP_047302283.1  leucine-rich repeat flightless-interacting protein 1 isoform X39

  33. XM_047446330.1XP_047302286.1  leucine-rich repeat flightless-interacting protein 1 isoform X43

  34. XM_047446331.1XP_047302287.1  leucine-rich repeat flightless-interacting protein 1 isoform X44

  35. XM_047446314.1XP_047302270.1  leucine-rich repeat flightless-interacting protein 1 isoform X22

  36. XM_047446305.1XP_047302261.1  leucine-rich repeat flightless-interacting protein 1 isoform X13

  37. XM_047446320.1XP_047302276.1  leucine-rich repeat flightless-interacting protein 1 isoform X28

  38. XM_047446300.1XP_047302256.1  leucine-rich repeat flightless-interacting protein 1 isoform X8

  39. XM_047446313.1XP_047302269.1  leucine-rich repeat flightless-interacting protein 1 isoform X21

  40. XM_047446321.1XP_047302277.1  leucine-rich repeat flightless-interacting protein 1 isoform X29

  41. XM_047446304.1XP_047302260.1  leucine-rich repeat flightless-interacting protein 1 isoform X12

  42. XM_047446308.1XP_047302264.1  leucine-rich repeat flightless-interacting protein 1 isoform X16

  43. XM_047446311.1XP_047302267.1  leucine-rich repeat flightless-interacting protein 1 isoform X19

  44. XM_047446324.1XP_047302280.1  leucine-rich repeat flightless-interacting protein 1 isoform X32

  45. XM_047446319.1XP_047302275.1  leucine-rich repeat flightless-interacting protein 1 isoform X27

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    238117567..238271644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344541.1XP_054200516.1  leucine-rich repeat flightless-interacting protein 1 isoform X34

  2. XM_054344542.1XP_054200517.1  leucine-rich repeat flightless-interacting protein 1 isoform X35

  3. XM_054344543.1XP_054200518.1  leucine-rich repeat flightless-interacting protein 1 isoform X36

  4. XM_054344549.1XP_054200524.1  leucine-rich repeat flightless-interacting protein 1 isoform X42

  5. XM_054344545.1XP_054200520.1  leucine-rich repeat flightless-interacting protein 1 isoform X38

  6. XM_054344552.1XP_054200527.1  leucine-rich repeat flightless-interacting protein 1 isoform X45

  7. XM_054344508.1XP_054200483.1  leucine-rich repeat flightless-interacting protein 1 isoform X1

  8. XM_054344510.1XP_054200485.1  leucine-rich repeat flightless-interacting protein 1 isoform X3

  9. XM_054344518.1XP_054200493.1  leucine-rich repeat flightless-interacting protein 1 isoform X11

  10. XM_054344512.1XP_054200487.1  leucine-rich repeat flightless-interacting protein 1 isoform X5

  11. XM_054344521.1XP_054200496.1  leucine-rich repeat flightless-interacting protein 1 isoform X14

  12. XM_054344509.1XP_054200484.1  leucine-rich repeat flightless-interacting protein 1 isoform X2

  13. XM_054344511.1XP_054200486.1  leucine-rich repeat flightless-interacting protein 1 isoform X4

  14. XM_054344514.1XP_054200489.1  leucine-rich repeat flightless-interacting protein 1 isoform X7

  15. XM_054344527.1XP_054200502.1  leucine-rich repeat flightless-interacting protein 1 isoform X20

  16. XM_054344513.1XP_054200488.1  leucine-rich repeat flightless-interacting protein 1 isoform X6

  17. XM_054344524.1XP_054200499.1  leucine-rich repeat flightless-interacting protein 1 isoform X17

  18. XM_054344517.1XP_054200492.1  leucine-rich repeat flightless-interacting protein 1 isoform X10

  19. XM_054344532.1XP_054200507.1  leucine-rich repeat flightless-interacting protein 1 isoform X25

  20. XM_054344525.1XP_054200500.1  leucine-rich repeat flightless-interacting protein 1 isoform X18

  21. XM_054344533.1XP_054200508.1  leucine-rich repeat flightless-interacting protein 1 isoform X26

  22. XM_054344516.1XP_054200491.1  leucine-rich repeat flightless-interacting protein 1 isoform X9

  23. XM_054344531.1XP_054200506.1  leucine-rich repeat flightless-interacting protein 1 isoform X24

  24. XM_054344537.1XP_054200512.1  leucine-rich repeat flightless-interacting protein 1 isoform X30

  25. XM_054344522.1XP_054200497.1  leucine-rich repeat flightless-interacting protein 1 isoform X15

  26. XM_054344538.1XP_054200513.1  leucine-rich repeat flightless-interacting protein 1 isoform X31

  27. XM_054344530.1XP_054200505.1  leucine-rich repeat flightless-interacting protein 1 isoform X23

  28. XM_054344540.1XP_054200515.1  leucine-rich repeat flightless-interacting protein 1 isoform X33

  29. XM_054344544.1XP_054200519.1  leucine-rich repeat flightless-interacting protein 1 isoform X37

  30. XM_054344547.1XP_054200522.1  leucine-rich repeat flightless-interacting protein 1 isoform X40

  31. XM_054344548.1XP_054200523.1  leucine-rich repeat flightless-interacting protein 1 isoform X41

  32. XM_054344546.1XP_054200521.1  leucine-rich repeat flightless-interacting protein 1 isoform X39

  33. XM_054344550.1XP_054200525.1  leucine-rich repeat flightless-interacting protein 1 isoform X43

  34. XM_054344551.1XP_054200526.1  leucine-rich repeat flightless-interacting protein 1 isoform X44

  35. XM_054344529.1XP_054200504.1  leucine-rich repeat flightless-interacting protein 1 isoform X22

  36. XM_054344520.1XP_054200495.1  leucine-rich repeat flightless-interacting protein 1 isoform X13

  37. XM_054344535.1XP_054200510.1  leucine-rich repeat flightless-interacting protein 1 isoform X28

  38. XM_054344515.1XP_054200490.1  leucine-rich repeat flightless-interacting protein 1 isoform X8

  39. XM_054344528.1XP_054200503.1  leucine-rich repeat flightless-interacting protein 1 isoform X21

  40. XM_054344536.1XP_054200511.1  leucine-rich repeat flightless-interacting protein 1 isoform X29

  41. XM_054344519.1XP_054200494.1  leucine-rich repeat flightless-interacting protein 1 isoform X12

  42. XM_054344523.1XP_054200498.1  leucine-rich repeat flightless-interacting protein 1 isoform X16

  43. XM_054344526.1XP_054200501.1  leucine-rich repeat flightless-interacting protein 1 isoform X19

  44. XM_054344539.1XP_054200514.1  leucine-rich repeat flightless-interacting protein 1 isoform X32

  45. XM_054344534.1XP_054200509.1  leucine-rich repeat flightless-interacting protein 1 isoform X27