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Lrrfip1 leucine rich repeat (in FLII) interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 16978, updated on 11-Jun-2024

Summary

Official Symbol
Lrrfip1provided by MGI
Official Full Name
leucine rich repeat (in FLII) interacting protein 1provided by MGI
Primary source
MGI:MGI:1342770
See related
Ensembl:ENSMUSG00000026305 AllianceGenome:MGI:1342770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fliiap1
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytosol and plasma membrane. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and integumental system. Orthologous to human LRRFIP1 (LRR binding FLII interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 22.2), placenta adult (RPKM 10.6) and 26 other tissues See more
Orthologs
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Genomic context

See Lrrfip1 in Genome Data Viewer
Location:
1 D; 1 46.03 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (90924652..91056666)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (90996930..91128944)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene prolactin releasing hormone Neighboring gene RAB17, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E4334 Neighboring gene STARR-positive B cell enhancer ABC_E3290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:92961823-92961976 Neighboring gene predicted gene, 35443 Neighboring gene RNA binding motif protein 44 Neighboring gene proteasome (prosome, macropain) 28 subunit, alpha pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leucine-rich repeat flightless-interacting protein 1
Names
FLAP (FLI LRR associated protein)
FLI-LRR-associated protein 1
H186 FLAP
LRR FLII-interacting protein 1
flap-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111311.1NP_001104781.1  leucine-rich repeat flightless-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001104781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AK077637, AK134120, AK162191, AV024479, BB709810
    Consensus CDS
    CCDS48320.1
    UniProtKB/Swiss-Prot
    O70323, Q3TS94, Q3UZ39
    Related
    ENSMUSP00000095254.4, ENSMUST00000097649.10
    Conserved Domains (1) summary
    pfam09738
    Location:42258
    DUF2051; Double stranded RNA binding protein (DUF2051)
  2. NM_001111312.1NP_001104782.1  leucine-rich repeat flightless-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001104782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region and contains different segments for both UTRs, compared to variant 1. The resulting protein (isoform 3) is shorter and has distinct N- and C-termini when it is compared to isoform 1.
    Source sequence(s)
    AF045573, AI452149, AK041162, BC145642, CJ154753
    Consensus CDS
    CCDS48319.1
    UniProtKB/TrEMBL
    G5E8E1, Q8BLV4
    Related
    ENSMUSP00000065850.7, ENSMUST00000068116.13
    Conserved Domains (1) summary
    pfam09738
    Location:52352
    DUF2051; Double stranded RNA binding protein (DUF2051)
  3. NM_001310732.1NP_001297661.1  leucine-rich repeat flightless-interacting protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 3' UTR and in the coding region, but maintains the reading frame compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus and lacks several internal segments compared to isoform 1.
    Source sequence(s)
    AC162883
    Consensus CDS
    CCDS78647.1
    UniProtKB/TrEMBL
    A0A087WPK3, A6H5U5
    Related
    ENSMUSP00000139811.2, ENSMUST00000189617.3
    Conserved Domains (2) summary
    COG1340
    Location:385655
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cl12057
    Location:385463
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  4. NM_008515.4NP_032541.1  leucine-rich repeat flightless-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_032541.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region and contains a different 3' UTR, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AF045573, AI452149, AK077637, BC145642, BY739242
    Consensus CDS
    CCDS35662.1
    UniProtKB/TrEMBL
    E9Q9T1
    Related
    ENSMUSP00000095255.4, ENSMUST00000097650.10
    Conserved Domains (1) summary
    COG1340
    Location:350620
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    90924652..91056666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529209.4XP_006529272.1  leucine-rich repeat flightless-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6H5U5
    Related
    ENSMUSP00000139497.2, ENSMUST00000185531.7
    Conserved Domains (3) summary
    TIGR04211
    Location:398486
    SH3_and_anchor; SH3 domain protein
    pfam09738
    Location:260613
    LRRFIP; LRRFIP family
    pfam11932
    Location:629688
    DUF3450; Protein of unknown function (DUF3450)
  2. XM_017318960.2XP_017174449.1  leucine-rich repeat flightless-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A6H5U5
    Conserved Domains (2) summary
    pfam09738
    Location:260582
    LRRFIP; LRRFIP family
    pfam11932
    Location:598657
    DUF3450; Protein of unknown function (DUF3450)
  3. XM_017318958.2XP_017174447.1  leucine-rich repeat flightless-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A6H5U5
    Conserved Domains (3) summary
    TIGR04211
    Location:374462
    SH3_and_anchor; SH3 domain protein
    pfam09738
    Location:260589
    LRRFIP; LRRFIP family
    pfam11932
    Location:605664
    DUF3450; Protein of unknown function (DUF3450)
  4. XM_017318961.2XP_017174450.1  leucine-rich repeat flightless-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    A6H5U5
    Conserved Domains (2) summary
    pfam09738
    Location:245574
    LRRFIP; LRRFIP family
    pfam11932
    Location:590649
    DUF3450; Protein of unknown function (DUF3450)
  5. XM_017318969.2XP_017174458.1  leucine-rich repeat flightless-interacting protein 1 isoform X5

    UniProtKB/TrEMBL
    E9Q9T1
    Conserved Domains (2) summary
    pfam09738
    Location:223552
    LRRFIP; LRRFIP family
    pfam11932
    Location:568627
    DUF3450; Protein of unknown function (DUF3450)
  6. XM_017318974.2XP_017174463.1  leucine-rich repeat flightless-interacting protein 1 isoform X6

    UniProtKB/TrEMBL
    E9Q9T1
    Conserved Domains (2) summary
    pfam09738
    Location:197526
    LRRFIP; LRRFIP family
    pfam11932
    Location:542601
    DUF3450; Protein of unknown function (DUF3450)
  7. XM_017318999.2XP_017174488.1  leucine-rich repeat flightless-interacting protein 1 isoform X9

    UniProtKB/TrEMBL
    E9Q9T1
    Conserved Domains (2) summary
    pfam09738
    Location:197495
    LRRFIP; LRRFIP family
    pfam11932
    Location:511570
    DUF3450; Protein of unknown function (DUF3450)
  8. XM_017319017.2XP_017174506.1  leucine-rich repeat flightless-interacting protein 1 isoform X14

    Conserved Domains (2) summary
    pfam09738
    Location:197464
    LRRFIP; LRRFIP family
    pfam11932
    Location:480539
    DUF3450; Protein of unknown function (DUF3450)
  9. XM_036162412.1XP_036018305.1  leucine-rich repeat flightless-interacting protein 1 isoform X13

    Conserved Domains (2) summary
    pfam09738
    Location:175466
    LRRFIP; LRRFIP family
    pfam11932
    Location:482541
    DUF3450; Protein of unknown function (DUF3450)
  10. XM_017318996.2XP_017174485.1  leucine-rich repeat flightless-interacting protein 1 isoform X8

    UniProtKB/TrEMBL
    E9Q9T1
    Conserved Domains (2) summary
    pfam09738
    Location:175504
    LRRFIP; LRRFIP family
    pfam11932
    Location:520579
    DUF3450; Protein of unknown function (DUF3450)
  11. XM_017319004.2XP_017174493.1  leucine-rich repeat flightless-interacting protein 1 isoform X12

    UniProtKB/TrEMBL
    E9Q9T1
    Conserved Domains (2) summary
    pfam09738
    Location:175473
    LRRFIP; LRRFIP family
    pfam11932
    Location:489548
    DUF3450; Protein of unknown function (DUF3450)
  12. XM_036162414.1XP_036018307.1  leucine-rich repeat flightless-interacting protein 1 isoform X16

    Conserved Domains (2) summary
    pfam09738
    Location:175442
    LRRFIP; LRRFIP family
    pfam11932
    Location:458517
    DUF3450; Protein of unknown function (DUF3450)
  13. XM_036162407.1XP_036018300.1  leucine-rich repeat flightless-interacting protein 1 isoform X7

    UniProtKB/TrEMBL
    E9Q9T1
    Conserved Domains (2) summary
    pfam09738
    Location:184513
    LRRFIP; LRRFIP family
    pfam11932
    Location:529588
    DUF3450; Protein of unknown function (DUF3450)
  14. XM_036162413.1XP_036018306.1  leucine-rich repeat flightless-interacting protein 1 isoform X15

    Conserved Domains (2) summary
    pfam09738
    Location:162453
    LRRFIP; LRRFIP family
    pfam11932
    Location:469528
    DUF3450; Protein of unknown function (DUF3450)
  15. XM_017319000.2XP_017174489.1  leucine-rich repeat flightless-interacting protein 1 isoform X10

    UniProtKB/TrEMBL
    E9Q9T1
    Conserved Domains (2) summary
    pfam09738
    Location:162491
    LRRFIP; LRRFIP family
    pfam11932
    Location:507566
    DUF3450; Protein of unknown function (DUF3450)
  16. XM_036162428.1XP_036018321.1  leucine-rich repeat flightless-interacting protein 1 isoform X23

    Conserved Domains (2) summary
    pfam09738
    Location:52375
    LRRFIP; LRRFIP family
    pfam11932
    Location:391450
    DUF3450; Protein of unknown function (DUF3450)
  17. XM_030251813.1XP_030107673.1  leucine-rich repeat flightless-interacting protein 1 isoform X22

    UniProtKB/TrEMBL
    Q8BLV4
    Conserved Domains (2) summary
    pfam09738
    Location:52379
    LRRFIP; LRRFIP family
    pfam11932
    Location:395454
    DUF3450; Protein of unknown function (DUF3450)
  18. XM_030251811.1XP_030107671.1  leucine-rich repeat flightless-interacting protein 1 isoform X17

    Conserved Domains (2) summary
    pfam09738
    Location:52417
    LRRFIP; LRRFIP family
    pfam11932
    Location:433492
    DUF3450; Protein of unknown function (DUF3450)
  19. XM_030251812.1XP_030107672.1  leucine-rich repeat flightless-interacting protein 1 isoform X20

    Conserved Domains (2) summary
    pfam09738
    Location:52386
    LRRFIP; LRRFIP family
    pfam11932
    Location:402461
    DUF3450; Protein of unknown function (DUF3450)
  20. XM_030251816.1XP_030107676.1  leucine-rich repeat flightless-interacting protein 1 isoform X25

    UniProtKB/TrEMBL
    Q8BLV4
    Conserved Domains (2) summary
    pfam09738
    Location:52355
    LRRFIP; LRRFIP family
    pfam11932
    Location:371430
    DUF3450; Protein of unknown function (DUF3450)
  21. XM_030251823.1XP_030107683.1  leucine-rich repeat flightless-interacting protein 1 isoform X32

    Conserved Domains (2) summary
    pfam09738
    Location:52415
    LRRFIP; LRRFIP family
    pfam11932
    Location:431490
    DUF3450; Protein of unknown function (DUF3450)
  22. XM_030251821.1XP_030107681.1  leucine-rich repeat flightless-interacting protein 1 isoform X31

    UniProtKB/TrEMBL
    Q8BLV4
    Conserved Domains (2) summary
    pfam09738
    Location:52384
    LRRFIP; LRRFIP family
    pfam11932
    Location:400459
    DUF3450; Protein of unknown function (DUF3450)
  23. XM_030251824.1XP_030107684.1  leucine-rich repeat flightless-interacting protein 1 isoform X33

    Conserved Domains (2) summary
    pfam09738
    Location:52391
    LRRFIP; LRRFIP family
    pfam11932
    Location:407466
    DUF3450; Protein of unknown function (DUF3450)
  24. XM_030251814.1XP_030107674.1  leucine-rich repeat flightless-interacting protein 1 isoform X24

    UniProtKB/TrEMBL
    Q8BLV4
    Conserved Domains (2) summary
    pfam09738
    Location:52360
    LRRFIP; LRRFIP family
    pfam11932
    Location:376435
    DUF3450; Protein of unknown function (DUF3450)
  25. XM_006529216.3XP_006529279.1  leucine-rich repeat flightless-interacting protein 1 isoform X29

    See identical proteins and their annotated locations for XP_006529279.1

    UniProtKB/TrEMBL
    Q8BLV4
    Conserved Domains (2) summary
    pfam09738
    Location:52329
    LRRFIP; LRRFIP family
    pfam11932
    Location:345404
    DUF3450; Protein of unknown function (DUF3450)
  26. XM_036162410.1XP_036018303.1  leucine-rich repeat flightless-interacting protein 1 isoform X11

    UniProtKB/TrEMBL
    E9Q9T1
    Conserved Domains (2) summary
    pfam09738
    Location:152481
    LRRFIP; LRRFIP family
    pfam11932
    Location:497556
    DUF3450; Protein of unknown function (DUF3450)
  27. XM_036162419.1XP_036018312.1  leucine-rich repeat flightless-interacting protein 1 isoform X19

    Conserved Domains (2) summary
    pfam09738
    Location:98396
    LRRFIP; LRRFIP family
    pfam11932
    Location:412471
    DUF3450; Protein of unknown function (DUF3450)
  28. XM_036162433.1XP_036018326.1  leucine-rich repeat flightless-interacting protein 1 isoform X27

    Conserved Domains (2) summary
    pfam09738
    Location:42345
    LRRFIP; LRRFIP family
    pfam11932
    Location:361420
    DUF3450; Protein of unknown function (DUF3450)
  29. XM_036162434.1XP_036018327.1  leucine-rich repeat flightless-interacting protein 1 isoform X28

    UniProtKB/TrEMBL
    Q8BLV4
    Conserved Domains (2) summary
    pfam09738
    Location:42343
    LRRFIP; LRRFIP family
    pfam11932
    Location:359418
    DUF3450; Protein of unknown function (DUF3450)
  30. XM_006529214.2XP_006529277.1  leucine-rich repeat flightless-interacting protein 1 isoform X21

    See identical proteins and their annotated locations for XP_006529277.1

    Conserved Domains (2) summary
    pfam09738
    Location:42381
    LRRFIP; LRRFIP family
    pfam11932
    Location:397456
    DUF3450; Protein of unknown function (DUF3450)
  31. XM_036162432.1XP_036018325.1  leucine-rich repeat flightless-interacting protein 1 isoform X26

    Conserved Domains (2) summary
    pfam09738
    Location:42350
    LRRFIP; LRRFIP family
    pfam11932
    Location:366425
    DUF3450; Protein of unknown function (DUF3450)
  32. XM_006529215.2XP_006529278.1  leucine-rich repeat flightless-interacting protein 1 isoform X30

    Conserved Domains (2) summary
    pfam09738
    Location:42319
    LRRFIP; LRRFIP family
    pfam11932
    Location:335394
    DUF3450; Protein of unknown function (DUF3450)
  33. XM_036162418.1XP_036018311.1  leucine-rich repeat flightless-interacting protein 1 isoform X18

    Conserved Domains (2) summary
    pfam09738
    Location:47400
    LRRFIP; LRRFIP family
    pfam11932
    Location:416475
    DUF3450; Protein of unknown function (DUF3450)

RNA

  1. XR_004940657.1 RNA Sequence

  2. XR_004940659.1 RNA Sequence

  3. XR_004940661.1 RNA Sequence

  4. XR_004940660.1 RNA Sequence

  5. XR_004940663.1 RNA Sequence

  6. XR_004940664.1 RNA Sequence

  7. XR_004940667.1 RNA Sequence

  8. XR_004940666.1 RNA Sequence

  9. XR_004940670.1 RNA Sequence

  10. XR_004940665.1 RNA Sequence

  11. XR_004940669.1 RNA Sequence

  12. XR_004940668.1 RNA Sequence

  13. XR_004940658.1 RNA Sequence

  14. XR_004940662.1 RNA Sequence