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FDXACB1 ferredoxin-fold anticodon binding domain containing 1 [ Homo sapiens (human) ]

Gene ID: 91893, updated on 5-Jan-2022

Summary

Official Symbol
FDXACB1provided by HGNC
Official Full Name
ferredoxin-fold anticodon binding domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25110
See related
Ensembl:ENSG00000255561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hCG_2033039
Summary
This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 3.2), lymph node (RPKM 1.6) and 24 other tissues See more
Orthologs
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Genomic context

See FDXACB1 in Genome Data Viewer
Location:
11q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (111874056..111879165, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111744780..111749889, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene salt inducible kinase 2 Neighboring gene protein phosphatase 2 scaffold subunit Abeta Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene G protein subunit gamma 5 pseudogene 3 Neighboring gene chromosome 11 open reading frame 1 Neighboring gene ribosomal protein L37a pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ58308

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA (uridine-N3-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ferredoxin-fold anticodon-binding domain-containing protein 1
Names
FDX-ACDB domain-containing protein 1
hypothetical protein BC006136

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029081.1 RefSeqGene

    Range
    5293..10402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138378.3NP_612387.1  ferredoxin-fold anticodon-binding domain-containing protein 1

    See identical proteins and their annotated locations for NP_612387.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AW296845, BC006136, BC127680, CN260853
    Consensus CDS
    CCDS44729.1
    UniProtKB/Swiss-Prot
    Q9BRP7
    Related
    ENSP00000260257.4, ENST00000260257.9
    Conserved Domains (2) summary
    smart00896
    Location:530624
    FDX-ACB; Ferredoxin-fold anticodon binding domain
    pfam10354
    Location:7176
    DUF2431; Domain of unknown function (DUF2431)

RNA

  1. NR_038364.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' region compared to variant 1. This results in the creation of upstream open reading frames (uORFs) with strong Kozak signals that would interfere with translation of the downstream primary ORF; translation from the uORFs makes this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK311254, AW296845, BC006136

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    111874056..111879165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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