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ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 [ Homo sapiens (human) ]

Gene ID: 9181, updated on 4-Nov-2018

Summary

Official Symbol
ARHGEF2provided by HGNC
Official Full Name
Rho/Rac guanine nucleotide exchange factor 2provided by HGNC
Primary source
HGNC:HGNC:682
See related
Ensembl:ENSG00000116584 MIM:607560; Vega:OTTHUMG00000017464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GEF; P40; GEFH1; LFP40; GEF-H1; NEDMHM
Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Expression
Ubiquitous expression in lung (RPKM 15.7), spleen (RPKM 12.3) and 24 other tissues See more
Orthologs

Genomic context

See ARHGEF2 in Genome Data Viewer
Location:
1q22
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (155946839..155991262, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155916431..155953396, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985207 Neighboring gene relaxin family peptide/INSL5 receptor 4 Neighboring gene microRNA 6738 Neighboring gene uncharacterized LOC107985209 Neighboring gene uncharacterized LOC107985210 Neighboring gene uncharacterized LOC107985208 Neighboring gene signal sequence receptor subunit 2 Neighboring gene uncharacterized LOC105371729

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Neurodevelopmental disorder with midbrain and hindbrain malformations
MedGen: C4479613 OMIM: 617523 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ARHGEF2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
    Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
    NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
  • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
    Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
  • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
    Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
  • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
    Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
  • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Reelin signaling pathway, organism-specific biosystem
    Reelin signaling pathway
  • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RAC1 activity, organism-specific biosystem
    Regulation of RAC1 activity
  • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RhoA activity, organism-specific biosystem
    Regulation of RhoA activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
    p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45440, KIAA0651, DKFZp547L106, DKFZp547P1516

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rac GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Rac guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Rho GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
asymmetric neuroblast division IDA
Inferred from Direct Assay
more info
PubMed 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular hyperosmotic response ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport NAS
Non-traceable Author Statement
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of podosome assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Rho protein signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
podosome IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 2
Names
Rho/Rac guanine nucleotide exchange factor (GEF) 2
guanine nucleotide exchange factor H1
microtubule-regulated Rho-GEF
proliferating cell nucleolar antigen p40

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162383.1NP_001155855.1  rho guanine nucleotide exchange factor 2 isoform 1

    See identical proteins and their annotated locations for NP_001155855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI925929, BC020567, BC027722, CN388788
    Consensus CDS
    CCDS53376.1
    UniProtKB/Swiss-Prot
    Q92974
    Related
    ENSP00000354837.4, OTTHUMP00000018854, ENST00000361247.8, OTTHUMT00000046204
    Conserved Domains (4) summary
    cd00029
    Location:4085
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:236430
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:470585
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:473571
    PH; PH domain
  2. NM_001162384.1NP_001155856.1  rho guanine nucleotide exchange factor 2 isoform 2

    See identical proteins and their annotated locations for NP_001155856.1

    Status: VALIDATED

    Description
    Transcript Variant: Thsi variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal amino acid, as compared to isoform 1.
    Source sequence(s)
    AF486838, AI925929, AL512715, BC020567, CN388788
    Consensus CDS
    CCDS53375.1
    UniProtKB/Swiss-Prot
    Q92974
    Related
    ENSP00000314787.4, OTTHUMP00000018855, ENST00000313667.8, OTTHUMT00000046205
    Conserved Domains (4) summary
    cd00029
    Location:4085
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:235429
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:469584
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:472570
    PH; PH domain
  3. NM_001350110.1NP_001337039.1  rho guanine nucleotide exchange factor 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon, resulting in a distinct 5' UTR, use of a downstream start codon, and uses two alternate in-frame splice sites in the 5' and 3' coding regions, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and contains an internal segment compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).
    Source sequence(s)
    AI925929, AL512715, AL527706, BM476546, BM552445, DA344419
    Conserved Domains (4) summary
    cd00029
    Location:1358
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:209403
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:443558
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:774846
    DUF390; Protein of unknown function (DUF390)
  4. NM_001350111.1NP_001337040.1  rho guanine nucleotide exchange factor 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' exon, resulting in a distinct 5' UTR, use of a downstream start codon, and uses two alternate in-frame splice sites in the 5' and 3' coding regions, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and contains an internal segment compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).
    Source sequence(s)
    AI925929, AL512715, AL527706, BM146462, BM476546, BM552445, HY130236
    Conserved Domains (4) summary
    cd00029
    Location:1358
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:209403
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:443558
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:774846
    DUF390; Protein of unknown function (DUF390)
  5. NM_001350112.1NP_001337041.1  rho guanine nucleotide exchange factor 2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' exon, resulting in a distinct 5' UTR, use of an alternate start codon, and uses an alternate in-frame slice site in the 3' coding region. The resulting isoform (5) has a shorter N-terminus, and contains an internal segment compared to isoform 1.
    Source sequence(s)
    AI925929, AL355388, AL512715, AL527706, BF349572, BM476546, BM552445
    Conserved Domains (4) summary
    cd00029
    Location:2368
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:218412
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:452567
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:783855
    DUF390; Protein of unknown function (DUF390)
  6. NM_004723.3NP_004714.2  rho guanine nucleotide exchange factor 2 isoform 3

    See identical proteins and their annotated locations for NP_004714.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AI925929, AL512715, CN264153
    Consensus CDS
    CCDS1125.1
    UniProtKB/Swiss-Prot
    Q92974
    Related
    ENSP00000315325.7, OTTHUMP00000018856, ENST00000313695.11, OTTHUMT00000046206
    Conserved Domains (4) summary
    cd00029
    Location:1358
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:208402
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:442557
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:445543
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    155946839..155991262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450823.1XP_024306591.1  rho guanine nucleotide exchange factor 2 isoform X14

    Conserved Domains (3) summary
    cd00160
    Location:159353
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:393508
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:724796
    DUF390; Protein of unknown function (DUF390)
  2. XM_024450815.1XP_024306583.1  rho guanine nucleotide exchange factor 2 isoform X13

    Conserved Domains (3) summary
    cd00160
    Location:160354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:394509
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:725797
    DUF390; Protein of unknown function (DUF390)
  3. XM_005245591.4XP_005245648.1  rho guanine nucleotide exchange factor 2 isoform X9

    See identical proteins and their annotated locations for XP_005245648.1

    Conserved Domains (4) summary
    cd00029
    Location:2570
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:221415
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:455570
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:458556
    PH; PH domain
  4. XM_005245590.4XP_005245647.1  rho guanine nucleotide exchange factor 2 isoform X9

    See identical proteins and their annotated locations for XP_005245647.1

    Conserved Domains (4) summary
    cd00029
    Location:2570
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:221415
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:455570
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:458556
    PH; PH domain
  5. XM_005245588.3XP_005245645.1  rho guanine nucleotide exchange factor 2 isoform X6

    Conserved Domains (4) summary
    cd00029
    Location:4085
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:235429
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:469584
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:472570
    PH; PH domain
  6. XM_005245587.3XP_005245644.1  rho guanine nucleotide exchange factor 2 isoform X5

    Conserved Domains (4) summary
    cd00029
    Location:4085
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:236430
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:470585
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:473571
    PH; PH domain
  7. XM_006711623.4XP_006711686.1  rho guanine nucleotide exchange factor 2 isoform X13

    See identical proteins and their annotated locations for XP_006711686.1

    Conserved Domains (3) summary
    cd00160
    Location:160354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:394509
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:725797
    DUF390; Protein of unknown function (DUF390)
  8. XM_017002797.2XP_016858286.1  rho guanine nucleotide exchange factor 2 isoform X12

  9. XM_006711625.4XP_006711688.1  rho guanine nucleotide exchange factor 2 isoform X13

    See identical proteins and their annotated locations for XP_006711688.1

    Conserved Domains (3) summary
    cd00160
    Location:160354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:394509
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:725797
    DUF390; Protein of unknown function (DUF390)
  10. XM_006711626.3XP_006711689.1  rho guanine nucleotide exchange factor 2 isoform X13

    See identical proteins and their annotated locations for XP_006711689.1

    Conserved Domains (3) summary
    cd00160
    Location:160354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:394509
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:725797
    DUF390; Protein of unknown function (DUF390)
  11. XM_005245594.3XP_005245651.1  rho guanine nucleotide exchange factor 2 isoform X11

    See identical proteins and their annotated locations for XP_005245651.1

    Conserved Domains (4) summary
    cd00029
    Location:1358
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:209403
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:443558
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:774846
    DUF390; Protein of unknown function (DUF390)
  12. XM_005245589.5XP_005245646.1  rho guanine nucleotide exchange factor 2 isoform X7

    Conserved Domains (4) summary
    cd00029
    Location:3277
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:228422
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:462577
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:465563
    PH; PH domain
  13. XM_017002795.2XP_016858284.1  rho guanine nucleotide exchange factor 2 isoform X8

  14. XM_011510143.3XP_011508445.1  rho guanine nucleotide exchange factor 2 isoform X15

    Conserved Domains (3) summary
    cd00160
    Location:57251
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:291406
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:294392
    PH; PH domain
  15. XM_017002794.2XP_016858283.1  rho guanine nucleotide exchange factor 2 isoform X4

  16. XM_011510136.3XP_011508438.2  rho guanine nucleotide exchange factor 2 isoform X2

  17. XM_011510137.3XP_011508439.2  rho guanine nucleotide exchange factor 2 isoform X3

    Related
    ENSP00000476916.1, OTTHUMP00000018857, ENST00000462460.6
  18. XM_011510139.3XP_011508441.1  rho guanine nucleotide exchange factor 2 isoform X1

    Conserved Domains (4) summary
    cd00029
    Location:183228
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:379573
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:613728
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:616714
    PH; PH domain
  19. XM_017002798.2XP_016858287.1  rho guanine nucleotide exchange factor 2 isoform X13

    Conserved Domains (3) summary
    cd00160
    Location:160354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:394509
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:725797
    DUF390; Protein of unknown function (DUF390)
  20. XM_006711622.4XP_006711685.1  rho guanine nucleotide exchange factor 2 isoform X10

    Conserved Domains (4) summary
    cd00029
    Location:2368
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:219413
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:453568
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:456554
    PH; PH domain
  21. XM_006711624.4XP_006711687.1  rho guanine nucleotide exchange factor 2 isoform X13

    See identical proteins and their annotated locations for XP_006711687.1

    Conserved Domains (3) summary
    cd00160
    Location:160354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:394509
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cl25642
    Location:725797
    DUF390; Protein of unknown function (DUF390)
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