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Arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 [ Mus musculus (house mouse) ]

Gene ID: 16800, updated on 28-Dec-2022

Summary

Official Symbol
Arhgef2provided by MGI
Official Full Name
rho/rac guanine nucleotide exchange factor (GEF) 2provided by MGI
Primary source
MGI:MGI:103264
See related
Ensembl:ENSMUSG00000028059 AllianceGenome:MGI:103264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GEF; Lfc; P40; GEFH1; LFP40; Lbcl1; GEF-H1; mKIAA0651
Summary
Enables guanyl-nucleotide exchange factor activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; generation of neurons; and positive regulation of neuron migration. Acts upstream of or within several processes, including actin filament organization; negative regulation of podosome assembly; and regulation of Rho protein signal transduction. Located in several cellular components, including dendritic shaft; podosome; and postsynaptic density. Is expressed in several structures, including brain; dorsal root ganglion; and testis. Used to study neurodevelopmental disorder with midbrain and hindbrain malformations. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.5), lung adult (RPKM 11.9) and 27 other tissues See more
Orthologs
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Genomic context

See Arhgef2 in Genome Data Viewer
Location:
3; 3 F1
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88500427..88556839)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88593105..88649532)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene signal sequence receptor, beta Neighboring gene predicted gene, 52660 Neighboring gene predicted gene, 40090 Neighboring gene predicted gene 20652 Neighboring gene relaxin family peptide receptor 4 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene predicted gene, 25820

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within actin filament organization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in asymmetric neuroblast division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 2
Names
LBC'S first cousin
guanine nucleotide exchange factor H1
lymphoid blast crisis-like 1
oncogene LFC
rhobin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198911.2NP_001185840.1  rho guanine nucleotide exchange factor 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences at its 5' end, including a different translation initiation site, compared to variant 1. Variant 2 encodes a shorter protein (isoform 2) with a different N-terminus, compared to isoform 1.
    Source sequence(s)
    AC145168
    Consensus CDS
    CCDS57220.1
    UniProtKB/Swiss-Prot
    Q60875
    UniProtKB/TrEMBL
    H3BJ45
    Related
    ENSMUSP00000134840.2, ENSMUST00000177498.8
    Conserved Domains (4) summary
    cd00029
    Location:2570
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:220414
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:454569
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:457555
    PH; PH domain
  2. NM_001198912.2NP_001185841.1  rho guanine nucleotide exchange factor 2 isoform 3

    See identical proteins and their annotated locations for NP_001185841.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 5' UTR and uses a downstream in-frame translation initiation site, compared to variant 1. Variant 3 encodes a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC145168
    Consensus CDS
    CCDS57222.1
    UniProtKB/Swiss-Prot
    Q60875
    Related
    ENSMUSP00000103134.4, ENSMUST00000107510.10
    Conserved Domains (4) summary
    cd00029
    Location:1358
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:210404
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:773845
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:444559
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  3. NM_001198913.2NP_001185842.1  rho guanine nucleotide exchange factor 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences at its 5' end and uses a downstream in-frame translation initiation site, compared to variant 1. Variant 4 encodes a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC145168
    Consensus CDS
    CCDS57221.1
    UniProtKB/Swiss-Prot
    Q60875
    Related
    ENSMUSP00000127843.3, ENSMUST00000170653.9
    Conserved Domains (4) summary
    cd00029
    Location:1358
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:208402
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:771843
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:442557
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  4. NM_001377126.1NP_001364055.1  rho guanine nucleotide exchange factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC145168
    Conserved Domains (3) summary
    cd00160
    Location:229423
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:463578
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cd20877
    Location:2787
    C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
  5. NM_008487.4NP_032513.3  rho guanine nucleotide exchange factor 2 isoform 1

    See identical proteins and their annotated locations for NP_032513.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC145168
    Consensus CDS
    CCDS17481.1
    UniProtKB/Swiss-Prot
    Q60875, Q9ESG7
    Related
    ENSMUSP00000029694.8, ENSMUST00000029694.14
    Conserved Domains (4) summary
    cd00029
    Location:4085
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:237431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:471586
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:474572
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88500427..88556839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240027.4XP_011238329.1  rho guanine nucleotide exchange factor 2 isoform X4

    Conserved Domains (4) summary
    cd00029
    Location:240285
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:437631
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:10001072
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:671786
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  2. XM_006501058.4XP_006501121.1  rho guanine nucleotide exchange factor 2 isoform X1

    Related
    ENSMUSP00000135168.3, ENSMUST00000175903.9
    Conserved Domains (4) summary
    cd00029
    Location:240285
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:437631
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:10001072
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:671786
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  3. XM_006501059.4XP_006501122.1  rho guanine nucleotide exchange factor 2 isoform X2

    Conserved Domains (4) summary
    cd00029
    Location:240285
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:435629
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:9981070
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:669784
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  4. XM_006501060.4XP_006501123.1  rho guanine nucleotide exchange factor 2 isoform X3

    Conserved Domains (4) summary
    cd00029
    Location:173218
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:370564
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:9331005
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:604719
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  5. XM_006501066.2XP_006501129.1  rho guanine nucleotide exchange factor 2 isoform X8

    See identical proteins and their annotated locations for XP_006501129.1

    UniProtKB/TrEMBL
    H3BJ40
    Related
    ENSMUSP00000134834.2, ENSMUST00000176500.8
    Conserved Domains (4) summary
    cd00029
    Location:2570
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:222416
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:785857
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:456571
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  6. XM_030252438.2XP_030108298.1  rho guanine nucleotide exchange factor 2 isoform X6

    Conserved Domains (4) summary
    cd00029
    Location:4085
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:235429
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:798870
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:469584
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  7. XM_006501067.5XP_006501130.1  rho guanine nucleotide exchange factor 2 isoform X9

    See identical proteins and their annotated locations for XP_006501130.1

    UniProtKB/Swiss-Prot
    Q60875
    Conserved Domains (4) summary
    cd00029
    Location:1358
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:210404
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:773845
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:444559
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  8. XM_030252439.2XP_030108299.1  rho guanine nucleotide exchange factor 2 isoform X10

    Conserved Domains (4) summary
    cd00029
    Location:1358
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:208402
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:771843
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:442557
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  9. XM_036162907.1XP_036018800.1  rho guanine nucleotide exchange factor 2 isoform X5

    Conserved Domains (3) summary
    cd00160
    Location:239433
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:473588
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    cd20877
    Location:3797
    C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
  10. XM_036162908.1XP_036018801.1  rho guanine nucleotide exchange factor 2 isoform X11

    Conserved Domains (2) summary
    cd00160
    Location:58252
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:292407
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  11. XM_006501065.4XP_006501128.1  rho guanine nucleotide exchange factor 2 isoform X7

    Conserved Domains (4) summary
    cd00029
    Location:3277
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:227421
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    TIGR02680
    Location:790862
    TIGR02680; TIGR02680 family protein
    cd13393
    Location:461576
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
  12. XM_036162909.1XP_036018802.1  rho guanine nucleotide exchange factor 2 isoform X11

    Conserved Domains (2) summary
    cd00160
    Location:58252
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13393
    Location:292407
    PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain