Format

Send to:

Choose Destination

TDRD12 tudor domain containing 12 [ Homo sapiens (human) ]

Gene ID: 91646, updated on 25-Jan-2022

Summary

Official Symbol
TDRD12provided by HGNC
Official Full Name
tudor domain containing 12provided by HGNC
Primary source
HGNC:HGNC:25044
See related
Ensembl:ENSG00000173809 AllianceGenome:HGNC:25044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECAT8
Summary
Predicted to enable ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be involved in several processes, including gamete generation; gene silencing by RNA; and piRNA metabolic process. Predicted to be part of PET complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis (RPKM 4.5), ovary (RPKM 0.8) and 3 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TDRD12 in Genome Data Viewer
Location:
19q13.11
Exon count:
35
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (32719767..32829580)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (33210673..33320486)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 9 binding protein Neighboring gene nudix hydrolase 19 Neighboring gene uncharacterized LOC105372368 Neighboring gene Sharpr-MPRA regulatory region 1108 Neighboring gene glial cells missing transcription factor 1 pseudogene Neighboring gene solute carrier family 7 member 9 Neighboring gene RN7SK pseudogene 22 Neighboring gene centrosomal protein 89 Neighboring gene ribosomal protein L31 pseudogene 60

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13072

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA methylation involved in gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gene silencing by RNA ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in male meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in piRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of PET complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
putative ATP-dependent RNA helicase TDRD12
Names
ES cell associated transcript 8
ES cell-associated transcript 8 protein
tudor domain-containing protein 12
NP_001104292.1
NP_001353031.1
XP_011525773.1
XP_011525775.1
XP_011525776.1
XP_011525777.1
XP_011525778.1
XP_016882947.1
XP_016882948.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110822.2NP_001104292.1  putative ATP-dependent RNA helicase TDRD12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB211063, AC008736, BC049000
    Consensus CDS
    CCDS46038.1
    UniProtKB/Swiss-Prot
    Q587J7
    Related
    ENSP00000390621.2, ENST00000421545.2
    Conserved Domains (2) summary
    cd04508
    Location:60109
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:10128
    TUDOR; Tudor domain
  2. NM_001366102.1NP_001353031.1  putative ATP-dependent RNA helicase TDRD12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008736, AC008805
    Conserved Domains (3) summary
    COG0513
    Location:422762
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:10128
    TUDOR; Tudor domain
    cl00175
    Location:11881292
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    32719767..32829580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527471.3XP_011525773.1  putative ATP-dependent RNA helicase TDRD12 isoform X1

    Related
    ENSP00000496698.1, ENST00000647536.1
    Conserved Domains (5) summary
    cd04508
    Location:60109
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    COG0513
    Location:422881
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:10128
    TUDOR; Tudor domain
    cl00175
    Location:11931297
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
    cl21455
    Location:419635
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011527473.3XP_011525775.1  putative ATP-dependent RNA helicase TDRD12 isoform X3

    Conserved Domains (5) summary
    cd04508
    Location:60109
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    COG0513
    Location:422881
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:10128
    TUDOR; Tudor domain
    cl00175
    Location:11931297
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
    cl21455
    Location:419635
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011527475.2XP_011525777.1  putative ATP-dependent RNA helicase TDRD12 isoform X5

    Conserved Domains (5) summary
    cd06463
    Location:11971276
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd04508
    Location:60109
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    COG0513
    Location:422881
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:10128
    TUDOR; Tudor domain
    cl21455
    Location:419635
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011527474.3XP_011525776.1  putative ATP-dependent RNA helicase TDRD12 isoform X4

    Conserved Domains (4) summary
    COG0513
    Location:382841
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:10107
    TUDOR; Tudor domain
    cl00175
    Location:11531257
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
    cl21455
    Location:379595
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_017027458.1XP_016882947.1  putative ATP-dependent RNA helicase TDRD12 isoform X6

    Conserved Domains (5) summary
    cd06463
    Location:11971276
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd04508
    Location:60109
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    COG0513
    Location:422881
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:10128
    TUDOR; Tudor domain
    cl21455
    Location:419635
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_011527476.2XP_011525778.1  putative ATP-dependent RNA helicase TDRD12 isoform X7

    Related
    ENSP00000416248.2, ENST00000444215.6
    Conserved Domains (4) summary
    cd04508
    Location:60109
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    COG0513
    Location:422881
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00567
    Location:10128
    TUDOR; Tudor domain
    cl21455
    Location:419635
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_017027459.2XP_016882948.1  putative ATP-dependent RNA helicase TDRD12 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001015890.1: Suppressed sequence

    Description
    NM_001015890.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Support Center