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SLC28A2 solute carrier family 28 member 2 [ Homo sapiens (human) ]

Gene ID: 9153, updated on 13-Mar-2020

Summary

Official Symbol
SLC28A2provided by HGNC
Official Full Name
solute carrier family 28 member 2provided by HGNC
Primary source
HGNC:HGNC:11002
See related
Ensembl:ENSG00000137860 MIM:606208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNT2; HCNT2; SPNT1; HsT17153
Expression
Biased expression in small intestine (RPKM 43.4), duodenum (RPKM 31.3) and 4 other tissues See more
Orthologs

Genomic context

See SLC28A2 in Genome Data Viewer
Location:
15q21.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (45252234..45277846)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45544428..45568132)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tRNA-His (anticodon GTG) 1-9 Neighboring gene H3 histone pseudogene 39 Neighboring gene uncharacterized LOC101928414 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene THAP domain containing 12 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • FLJ21468, MGC138252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleoside transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside:sodium symporter activity TAS
Traceable Author Statement
more info
 
purine nucleoside transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
nucleoside transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
purine nucleoside transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/nucleoside cotransporter 2
Names
CNT 2
Na(+)/nucleoside cotransporter 2
SPNT
concentrative nucleoside transporter 2
sodium-coupled nucleoside transporter 2
sodium/purine nucleoside co-transporter
solute carrier family 28 (concentrative nucleoside transporter), member 2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004212.4NP_004203.2  sodium/nucleoside cotransporter 2

    See identical proteins and their annotated locations for NP_004203.2

    Status: VALIDATED

    Source sequence(s)
    AC051619, AK222709, AK291974, BC112047
    Consensus CDS
    CCDS10121.1
    UniProtKB/Swiss-Prot
    O43868
    UniProtKB/TrEMBL
    Q2M2A7, Q53H72
    Related
    ENSP00000315006.4, ENST00000347644.8
    Conserved Domains (1) summary
    TIGR00804
    Location:174585
    nupC; nucleoside transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    45252234..45277846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522198.2XP_011520500.1  sodium/nucleoside cotransporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011520500.1

    UniProtKB/Swiss-Prot
    O43868
    Conserved Domains (1) summary
    TIGR00804
    Location:174585
    nupC; nucleoside transporter
  2. XM_011522199.1XP_011520501.1  sodium/nucleoside cotransporter 2 isoform X2

    Conserved Domains (4) summary
    TIGR00804
    Location:174549
    nupC; nucleoside transporter
    pfam01773
    Location:179248
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:362549
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:260356
    Gate; Nucleoside recognition
  3. XM_011522201.2XP_011520503.1  sodium/nucleoside cotransporter 2 isoform X4

    Conserved Domains (4) summary
    TIGR00804
    Location:174549
    nupC; nucleoside transporter
    pfam01773
    Location:179248
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:362549
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:260356
    Gate; Nucleoside recognition
  4. XM_011522200.2XP_011520502.1  sodium/nucleoside cotransporter 2 isoform X3

    Conserved Domains (4) summary
    TIGR00804
    Location:174507
    nupC; nucleoside transporter
    pfam01773
    Location:179248
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:362505
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:260356
    Gate; Nucleoside recognition
  5. XM_011522202.2XP_011520504.1  sodium/nucleoside cotransporter 2 isoform X5

    Conserved Domains (2) summary
    pfam07662
    Location:67290
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:761
    Gate; Nucleoside recognition
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