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CCNE2 cyclin E2 [ Homo sapiens (human) ]

Gene ID: 9134, updated on 6-Sep-2021

Summary

Official Symbol
CCNE2provided by HGNC
Official Full Name
cyclin E2provided by HGNC
Primary source
HGNC:HGNC:1590
See related
Ensembl:ENSG00000175305 MIM:603775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYCE2
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 6.8), bone marrow (RPKM 6.2) and 20 other tissues See more
Orthologs
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Genomic context

See CCNE2 in Genome Data Viewer
Location:
8q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (94880224..94896671, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95892452..95907429, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene epithelial splicing regulatory protein 1 Neighboring gene ribosomal protein S15a pseudogene 26 Neighboring gene dpy-19 like 4 Neighboring gene integrator complex subunit 8 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 6 Neighboring gene tumor protein p53 inducible nuclear protein 1 Neighboring gene Sharpr-MPRA regulatory region 2014

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome pairing at meiosis IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin E1-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin E2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin E2-CDK2 complex IDA
Inferred from Direct Assay
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029611.1 RefSeqGene

    Range
    5001..20031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057749.3NP_477097.1  G1/S-specific cyclin-E2

    See identical proteins and their annotated locations for NP_477097.1

    Status: REVIEWED

    Source sequence(s)
    AF091433, BJ990268, DB547256
    Consensus CDS
    CCDS6264.1
    UniProtKB/Swiss-Prot
    O96020
    UniProtKB/TrEMBL
    A0A024R9B0
    Related
    ENSP00000309181.4, ENST00000308108.9
    Conserved Domains (2) summary
    pfam00134
    Location:112239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241361
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    94880224..94896671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013958.1XP_016869447.1  G1/S-specific cyclin-E2 isoform X1

    UniProtKB/Swiss-Prot
    O96020
    UniProtKB/TrEMBL
    A0A024R9B0
    Related
    ENSP00000429089.1, ENST00000520509.5
    Conserved Domains (2) summary
    pfam00134
    Location:112239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241361
    Cyclin_C; Cyclin, C-terminal domain
  2. XM_017013959.1XP_016869448.1  G1/S-specific cyclin-E2 isoform X1

    UniProtKB/Swiss-Prot
    O96020
    UniProtKB/TrEMBL
    A0A024R9B0
    Conserved Domains (2) summary
    pfam00134
    Location:112239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241361
    Cyclin_C; Cyclin, C-terminal domain
  3. XM_011517366.2XP_011515668.1  G1/S-specific cyclin-E2 isoform X2

    Conserved Domains (1) summary
    pfam00134
    Location:112239
    Cyclin_N; Cyclin, N-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004702.2: Suppressed sequence

    Description
    NM_004702.2: This RefSeq was permanently suppressed because the transcript has insufficient support and is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_057735.1: Suppressed sequence

    Description
    NM_057735.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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