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Ccne2 cyclin E2 [ Mus musculus (house mouse) ]

Gene ID: 12448, updated on 12-Feb-2024

Summary

Official Symbol
Ccne2provided by MGI
Official Full Name
cyclin E2provided by MGI
Primary source
MGI:MGI:1329034
See related
Ensembl:ENSMUSG00000028212 AllianceGenome:MGI:1329034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within several processes, including DNA metabolic process; homologous chromosome pairing at meiosis; and regulation of protein localization. Part of cyclin E2-CDK2 complex. Is expressed in several structures, including cerebral cortex and genitourinary system. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma. Orthologous to human CCNE2 (cyclin E2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 11.2), liver E14.5 (RPKM 8.4) and 13 other tissues See more
Orthologs
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Genomic context

See Ccne2 in Genome Data Viewer
Location:
4 A1; 4 5.07 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11190489..11204781)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11190433..11204779)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:11070406-11070589 Neighboring gene STARR-seq mESC enhancer starr_09590 Neighboring gene microRNA 684-2 Neighboring gene STARR-seq mESC enhancer starr_09592 Neighboring gene STARR-positive B cell enhancer mm9_chr4:11093717-11094018 Neighboring gene transformation related protein 53 inducible nuclear protein 1 Neighboring gene RIKEN cDNA A630034I12 gene Neighboring gene STARR-seq mESC enhancer starr_09593 Neighboring gene STARR-seq mESC enhancer starr_09594 Neighboring gene STARR-positive B cell enhancer ABC_E9234 Neighboring gene integrator complex subunit 8 Neighboring gene STARR-seq mESC enhancer starr_09596 Neighboring gene dpy-19 like 4 Neighboring gene epithelial splicing regulatory protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cyclin E1-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cyclin E2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cyclin E2-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037134.3NP_001032211.1  G1/S-specific cyclin-E2 isoform 1

    See identical proteins and their annotated locations for NP_001032211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 3 and 5 encode the same isoform (1).
    Source sequence(s)
    AL840625
    Consensus CDS
    CCDS17965.1
    UniProtKB/Swiss-Prot
    Q9QWU5, Q9Z238
    UniProtKB/TrEMBL
    Q544H6, Q7TMS8
    Related
    ENSMUSP00000130693.2, ENSMUST00000170901.8
    Conserved Domains (2) summary
    pfam00134
    Location:112239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241361
    Cyclin_C; Cyclin, C-terminal domain
  2. NM_001282943.2NP_001269872.1  G1/S-specific cyclin-E2 isoform 1

    See identical proteins and their annotated locations for NP_001269872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 5 encode the same isoform (1).
    Source sequence(s)
    AL840625
    Consensus CDS
    CCDS17965.1
    UniProtKB/Swiss-Prot
    Q9QWU5, Q9Z238
    UniProtKB/TrEMBL
    Q544H6, Q7TMS8
    Related
    ENSMUSP00000103960.4, ENSMUST00000108324.4
    Conserved Domains (2) summary
    pfam00134
    Location:112239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241361
    Cyclin_C; Cyclin, C-terminal domain
  3. NM_001419967.1NP_001406896.1  G1/S-specific cyclin-E2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL840625
    UniProtKB/TrEMBL
    A2API1, Q7TMS8
  4. NM_001419968.1NP_001406897.1  G1/S-specific cyclin-E2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to varian 1. Variants 1, 3 and 5 encode the same isoform (1).
    Source sequence(s)
    AL840625
    UniProtKB/Swiss-Prot
    Q9QWU5, Q9Z238
    UniProtKB/TrEMBL
    Q544H6, Q7TMS8
  5. NM_001419969.1NP_001406898.1  G1/S-specific cyclin-E2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region and differs in the 5' UTR compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL840625
    UniProtKB/TrEMBL
    A2API1, Q7TMS8
  6. NM_009830.4NP_033960.1  G1/S-specific cyclin-E2 isoform 2

    See identical proteins and their annotated locations for NP_033960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL840625
    Consensus CDS
    CCDS17966.1
    UniProtKB/TrEMBL
    A2API1, Q7TMS8
    Related
    ENSMUSP00000029866.10, ENSMUST00000029866.16
    Conserved Domains (2) summary
    pfam00134
    Location:111238
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:240360
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11190489..11204781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537574.5XP_006537637.1  G1/S-specific cyclin-E2 isoform X1

    See identical proteins and their annotated locations for XP_006537637.1

    UniProtKB/Swiss-Prot
    Q9QWU5, Q9Z238
    UniProtKB/TrEMBL
    Q544H6, Q7TMS8
    Conserved Domains (2) summary
    pfam00134
    Location:112239
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:241361
    Cyclin_C; Cyclin, C-terminal domain