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SMC3 structural maintenance of chromosomes 3 [ Homo sapiens (human) ]

Gene ID: 9126, updated on 25-Nov-2021

Summary

Official Symbol
SMC3provided by HGNC
Official Full Name
structural maintenance of chromosomes 3provided by HGNC
Primary source
HGNC:HGNC:2468
See related
Ensembl:ENSG00000108055 MIM:606062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAM; BMH; HCAP; CDLS3; CSPG6; SMC3L1
Summary
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 37.2), bone marrow (RPKM 22.4) and 25 other tissues See more
Orthologs
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Genomic context

See SMC3 in Genome Data Viewer
Location:
10q25.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (110567695..110606048)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (112327453..112365806)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378483 Neighboring gene ribosomal protein L7 pseudogene 35 Neighboring gene Sharpr-MPRA regulatory region 1411 Neighboring gene RNA binding motif protein 20 Neighboring gene uncharacterized LOC112268066 Neighboring gene RN7SK pseudogene 288

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with SMC3 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
Vpr vpr HIV-1 Vpr decreases the amount of Smc1 and Smc3 proteins in the chromatin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables cohesin loading activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mediator complex binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule motor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic cell cycle IDA
Inferred from Direct Assay
more info
 
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sister chromatid cohesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome TAS
Traceable Author Statement
more info
 
located_in chromosome, centromeric region TAS
Traceable Author Statement
more info
 
part_of cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cohesin complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lateral element IEA
Inferred from Electronic Annotation
more info
 
part_of meiotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear meiotic cohesin complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of nuclear mitotic cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
structural maintenance of chromosomes protein 3
Names
SMC protein 3
basement membrane-associated chondroitin proteoglycan
chondroitin sulfate proteoglycan 6 (bamacan)
chromosome-associated polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012217.1 RefSeqGene

    Range
    5001..41944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_774

mRNA and Protein(s)

  1. NM_005445.4NP_005436.1  structural maintenance of chromosomes protein 3

    See identical proteins and their annotated locations for NP_005436.1

    Status: REVIEWED

    Source sequence(s)
    AF020043, AL359260, CA439554
    Consensus CDS
    CCDS31285.1
    UniProtKB/Swiss-Prot
    Q9UQE7
    Related
    ENSP00000354720.5, ENST00000361804.5
    Conserved Domains (1) summary
    COG1196
    Location:11194
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    110567695..110606048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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