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SMC3 structural maintenance of chromosomes 3 [ Homo sapiens (human) ]

Gene ID: 9126, updated on 5-Jan-2020

Summary

Official Symbol
SMC3provided by HGNC
Official Full Name
structural maintenance of chromosomes 3provided by HGNC
Primary source
HGNC:HGNC:2468
See related
Ensembl:ENSG00000108055 MIM:606062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAM; BMH; HCAP; CDLS3; CSPG6; SMC3L1
Summary
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 37.2), bone marrow (RPKM 22.4) and 25 other tissues See more
Orthologs

Genomic context

See SMC3 in Genome Data Viewer
Location:
10q25.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (110567695..110606048)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (112327449..112364392)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378483 Neighboring gene ribosomal protein L7 pseudogene 35 Neighboring gene Sharpr-MPRA regulatory region 1411 Neighboring gene RNA binding motif protein 20 Neighboring gene uncharacterized LOC112268066 Neighboring gene RN7SK pseudogene 288

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with SMC3 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
Vpr vpr HIV-1 Vpr decreases the amount of Smc1 and Smc3 proteins in the chromatin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
mediator complex binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
meiotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
sister chromatid cohesion NAS
Non-traceable Author Statement
more info
PubMed 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromosome TAS
Traceable Author Statement
more info
 
chromosome, centromeric region TAS
Traceable Author Statement
more info
 
cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
cohesin complex NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
lateral element IEA
Inferred from Electronic Annotation
more info
 
meiotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nuclear meiotic cohesin complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
structural maintenance of chromosomes protein 3
Names
SMC protein 3
basement membrane-associated chondroitin proteoglycan
chondroitin sulfate proteoglycan 6 (bamacan)
chromosome-associated polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012217.1 RefSeqGene

    Range
    5001..41944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_774

mRNA and Protein(s)

  1. NM_005445.4NP_005436.1  structural maintenance of chromosomes protein 3

    See identical proteins and their annotated locations for NP_005436.1

    Status: REVIEWED

    Source sequence(s)
    AF020043, AL359260, CA439554
    Consensus CDS
    CCDS31285.1
    UniProtKB/Swiss-Prot
    Q9UQE7
    Related
    ENSP00000354720.4, ENST00000361804.4
    Conserved Domains (1) summary
    COG1196
    Location:11194
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    110567695..110606048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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