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Smc3 structural maintenance of chromosomes 3 [ Mus musculus (house mouse) ]

Gene ID: 13006, updated on 8-Dec-2022

Summary

Official Symbol
Smc3provided by MGI
Official Full Name
structural maintenance of chromosomes 3provided by MGI
Primary source
MGI:MGI:1339795
See related
Ensembl:ENSMUSG00000024974 AllianceGenome:MGI:1339795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HCAP; SmcD; Cspg6; Mmip1; SMC-3; Bamacan
Summary
Enables chromatin binding activity and mediator complex binding activity. Acts upstream of or within meiotic cell cycle and stem cell population maintenance. Located in lateral element. Part of nuclear meiotic cohesin complex. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3. Orthologous to human SMC3 (structural maintenance of chromosomes 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 31.0), liver E14 (RPKM 18.2) and 17 other tissues See more
Orthologs
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Genomic context

See Smc3 in Genome Data Viewer
Location:
19; 19 D2
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (53588827..53634262)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (53600396..53645831)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54049 Neighboring gene nuclear transport factor 2, pseudogene 1 Neighboring gene RNA binding motif protein 20 Neighboring gene predicted gene, 46653 Neighboring gene VISTA enhancer mm64

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cohesin loader activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables mediator complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within meiotic cell cycle IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
part_of cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cohesin complex ISO
Inferred from Sequence Orthology
more info
 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
part_of meiotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of meiotic cohesin complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in synaptonemal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
structural maintenance of chromosomes protein 3
Names
SMC protein 3
basement membrane-associated chondroitin proteoglycan
chondroitin sulfate proteoglycan 6
chromosome segregation protein SmcD
mad member-interacting protein 1
structural maintenace of chromosomes 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007790.3NP_031816.2  structural maintenance of chromosomes protein 3

    See identical proteins and their annotated locations for NP_031816.2

    Status: VALIDATED

    Source sequence(s)
    AF047601, AK005647, AK165878
    Consensus CDS
    CCDS38025.1
    UniProtKB/Swiss-Prot
    Q9CW03, Q9QUS3
    UniProtKB/TrEMBL
    A0A6P5P1N9, A0A8C6ILA6, Q1HL32, Q3TMK9
    Related
    ENSMUSP00000025930.10, ENSMUST00000025930.10
    Conserved Domains (1) summary
    COG1196
    Location:11194
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    53588827..53634262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)