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AP5B1 adaptor related protein complex 5 subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 91056, updated on 3-Dec-2023

Summary

Official Symbol
AP5B1provided by HGNC
Official Full Name
adaptor related protein complex 5 subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:25104
See related
Ensembl:ENSG00000254470 MIM:614367; AllianceGenome:HGNC:25104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP-5; PP1030
Summary
Involved in endosomal transport. Located in lysosomal membrane. Part of AP-type membrane coat adaptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 18.6), spleen (RPKM 4.9) and 24 other tissues See more
Orthologs
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Genomic context

See AP5B1 in Genome Data Viewer
Location:
11q13.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65773898..65780976, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65768361..65775439, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65541369..65548447, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5003 Neighboring gene ribonuclease H2 subunit C Neighboring gene lysine acetyltransferase 5 Neighboring gene keratin 8 pseudogene 26 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65544816-65545720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65547529-65548431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65549161-65549818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65553239-65554220 Neighboring gene uncharacterized LOC124902693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5005 Neighboring gene OVOL1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65563211-65563711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65565291-65565814 Neighboring gene ovo like transcriptional repressor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65568897-65569617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3557 Neighboring gene Sharpr-MPRA regulatory region 4974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3558 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:65601289-65601501 Neighboring gene sorting nexin 32 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5009 Neighboring gene Sharpr-MPRA regulatory region 3467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65618925-65619786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5011

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp761E198

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of AP-5 adaptor complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of AP-type membrane coat adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of AP-type membrane coat adaptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in lysosomal membrane HDA PubMed 

General protein information

Preferred Names
AP-5 complex subunit beta-1
Names
AP-5 complex subunit beta
adaptor related protein complex 5 beta 1 subunit
adaptor-related protein complex 5 beta subunit
beta5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138368.5NP_612377.4  AP-5 complex subunit beta-1

    See identical proteins and their annotated locations for NP_612377.4

    Status: VALIDATED

    Source sequence(s)
    AP001266, BC109109, JQ313135
    Consensus CDS
    CCDS58146.1
    UniProtKB/Swiss-Prot
    A1L0S6, H6WUK2, Q0D2Q2, Q2VPB7, Q8N3J7, Q8WYH6
    Related
    ENSP00000454303.1, ENST00000532090.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    65773898..65780976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    65768361..65775439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)