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ESAM endothelial cell adhesion molecule [ Homo sapiens (human) ]

Gene ID: 90952, updated on 5-Aug-2018

Summary

Official Symbol
ESAMprovided by HGNC
Official Full Name
endothelial cell adhesion moleculeprovided by HGNC
Primary source
HGNC:HGNC:17474
See related
Ensembl:ENSG00000149564 MIM:614281; Vega:OTTHUMG00000151986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
W117m
Expression
Broad expression in placenta (RPKM 71.1), thyroid (RPKM 67.5) and 21 other tissues See more
Orthologs

Genomic context

See ESAM in Genome Data Viewer
Location:
11q24.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (124753123..124762327, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124623019..124632223, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene neurogranin Neighboring gene V-set and immunoglobulin domain containing 2 Neighboring gene uncharacterized LOC101929340 Neighboring gene Myb/SANT DNA binding domain containing 2 Neighboring gene uncharacterized LOC100507283 Neighboring gene E3 ubiquitin-protein ligase RNF181 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
adherens junction IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
endothelial cell-selective adhesion molecule
Names
2310008D05Rik
HUEL (C4orf1)-interacting protein
LP4791 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138961.2NP_620411.2  endothelial cell-selective adhesion molecule precursor

    See identical proteins and their annotated locations for NP_620411.2

    Status: VALIDATED

    Source sequence(s)
    AK075396, AP000866, DA257581
    Consensus CDS
    CCDS8453.1
    UniProtKB/Swiss-Prot
    Q96AP7
    Related
    ENSP00000278927.5, OTTHUMP00000200894, ENST00000278927.9, OTTHUMT00000324686
    Conserved Domains (2) summary
    smart00410
    Location:166241
    IG_like; Immunoglobulin like
    pfam07686
    Location:40150
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    124753123..124762327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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