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Esam endothelial cell-specific adhesion molecule [ Mus musculus (house mouse) ]

Gene ID: 69524, updated on 14-May-2024

Summary

Official Symbol
Esamprovided by MGI
Official Full Name
endothelial cell-specific adhesion moleculeprovided by MGI
Primary source
MGI:MGI:1916774
See related
Ensembl:ENSMUSG00000001946 AllianceGenome:MGI:1916774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Esam1; W117m; 2310008D05Rik
Summary
Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Located in adherens junction; bicellular tight junction; and plasma membrane. Is expressed in several structures, including cardiovascular system; liver; lung; nervous system; and placenta. Orthologous to human ESAM (endothelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 97.8), subcutaneous fat pad adult (RPKM 50.9) and 22 other tissues See more
Orthologs
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Genomic context

See Esam in Genome Data Viewer
Location:
9 A4; 9 20.77 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (37439385..37449615)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (37528089..37538319)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5061 Neighboring gene roundabout guidance receptor 3 Neighboring gene STARR-seq mESC enhancer starr_23807 Neighboring gene STARR-seq mESC enhancer starr_23808 Neighboring gene STARR-seq mESC enhancer starr_23809 Neighboring gene Myb/SANT-like DNA-binding domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_23812 Neighboring gene V-set and immunoglobulin domain containing 2 Neighboring gene neurogranin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cell-cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endothelial cell-selective adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027102.3NP_081378.1  endothelial cell-selective adhesion molecule precursor

    See identical proteins and their annotated locations for NP_081378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    AI414314, AK009223, BG077536, BQ043033, BY119695, CJ048383
    Consensus CDS
    CCDS22979.1
    UniProtKB/Swiss-Prot
    Q925F2
    UniProtKB/TrEMBL
    Q3U102
    Related
    ENSMUSP00000002011.8, ENSMUST00000002011.14
    Conserved Domains (3) summary
    smart00408
    Location:170234
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:169244
    IG_like; Immunoglobulin like
    pfam07686
    Location:42153
    V-set; Immunoglobulin V-set domain

RNA

  1. NR_136939.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC105958, AI414314

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    37439385..37449615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)