Format

Send to

Choose Destination
Atherosclerosis. 2015 Dec;243(2):546-52. doi: 10.1016/j.atherosclerosis.2015.10.092. Epub 2015 Oct 24.

Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study.

Author information

1
Division of Nephrology, University of California, San Francisco (UCSF), San Francisco, CA, USA. Electronic address: meyeon.park@ucsf.edu.
2
Kaiser Permanente, McLean, VA, USA.
3
Division of Cardiology, VA Puget Sound Health Care System, University of Washington, USA.
4
Division of Cardiology, VA Puget Sound Health Care System, University of Washington, USA; Division of Cardiology, University of California San Francisco and San Francisco General Hospital, USA.
5
Department of Medicine, San Francisco VA Hospital, San Francisco, CA, USA.
6
Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, USA.
7
Department of Medicine, San Francisco VA Hospital, San Francisco, CA, USA; Department of Medicine, UCSF, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, USA.

Abstract

BACKGROUND AND AIMS:

Endothelial cell-selective adhesion molecule (ESAM) is selectively expressed on vascular endothelium and is postulated to play a role in atherogenesis. We investigated the association of serum soluble ESAM (sESAM) levels with subsequent cardiovascular outcomes in patients with stable ischemic heart disease.

METHODS:

We measured sESAM levels in 981 patients with stable coronary disease enrolled between September 2000 and December 2002 in a prospective cohort study. Poisson regression models were used to define the relationship between baseline sESAM levels and cardiovascular outcomes, including myocardial infarction, heart failure hospitalization, and mortality.

RESULTS:

There were 293 occurrences of the composite endpoint over a median follow-up of 8.9 years. After adjusting for demographic and clinical risk factors, participants in the highest sESAM quartile (compared to the lower three sESAM quartiles) had a higher rate of the composite endpoint (incident rate ratio (IRR) 1.52 (95% CI 1.16-1.99) as well as of its individual components: myocardial infarction (IRR 1.64 (1.06-2.55)), heart failure hospitalizations (IRR 1.96 (1.32-2.81)), and death (IRR 1.5 (1.2-1.89)). These associations were no longer significant after adjustment for estimated glomerular filtration rate.

CONCLUSIONS:

sESAM levels associate with myocardial infarction, heart failure, and death after adjustment for demographic and clinical risk factors, but not after adjustment for kidney function. sESAM may be involved in the pathogenesis of concurrent kidney and cardiovascular disease.

KEYWORDS:

Atherosclerosis; Cardiovascular mortality; Endothelium; Kidney disease

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center