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CLDN10 claudin 10 [ Homo sapiens (human) ]

Gene ID: 9071, updated on 12-Oct-2019

Summary

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Official Symbol
CLDN10provided by HGNC
Official Full Name
claudin 10provided by HGNC
Primary source
HGNC:HGNC:2033
See related
Ensembl:ENSG00000134873 MIM:617579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSPL; HELIX; OSP-L; CPETRL3
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]
Expression
Biased expression in kidney (RPKM 32.5), salivary gland (RPKM 18.3) and 4 other tissues See more
Orthologs
mouse all

Genomic context

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See CLDN10 in Genome Data Viewer
Location:
13q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (95433588..95579759)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96085853..96232010)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370321 Neighboring gene mediator of cell motility 1 pseudogene 5 Neighboring gene CLDN10 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 5370 Neighboring gene Sharpr-MPRA regulatory region 2339 Neighboring gene DAZ interacting zinc finger protein 1 Neighboring gene DNAJC3 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CLDN10 single nucleotide polymorphism rs1325774 alters the risk of breast cancer in south chinese women. Liao J, et al. Medicine (Baltimore), 2018 Dec. PMID 30544377, Free PMC Article
  2. Expression of claudin 10 protein in hepatocellular carcinoma: impact on survival. Huang GW, et al. J Cancer Res Clin Oncol, 2011 Aug. PMID 21647678
  3. Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. Ip YC, et al. Mol Cancer Ther, 2007 Nov. PMID 18025272
  4. Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma. Cheung ST, et al. Clin Cancer Res, 2005 Jan 15. PMID 15701840
  5. Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. Klar J, et al. PLoS Genet, 2017 Jul. PMID 28686597, Free PMC Article

See all (35) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CLDN10 polymorphism of rs1325774 was significantly associated with an increased risk of breast cancer. After adjusting for age, the association remained statically significant. Furthermore, harbouring G allele in rs1325774 position was significantly associated with increased risk of breast cancer. However, no significant association among rs7333503, rs3751334, and breast cancer.
    Title: CLDN10 single nucleotide polymorphism rs1325774 alters the risk of breast cancer in south chinese women.
  2. These renal-derived features recapitulate several phenotypic aspects detected in mice with kidney specific loss of both claudin-10 isoforms. Our study adds to the spectrum of phenotypes caused by tight junction proteins and demonstrates a pivotal role for claudin-10b in maintaining paracellular Na+ permeability for sweat production and kidney function.
    Title: Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage.
  3. localization of Cldn3, Cldn7 and Cldn10 proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua
    Title: Claudin-3, claudin-7, and claudin-10 show different distribution patterns during decidualization and trophoblast invasion in mouse and human.
  4. An algorithm combining CLDN10, HMGA2, and LAMB3 transcripts was able to discriminate tumors from BTL samples (94% sensitivity and 96% specificity in validation set).
    Title: High Diagnostic Accuracy Based on CLDN10, HMGA2, and LAMB3 Transcripts in Papillary Thyroid Carcinoma.
  5. Expression of CLDN1 and CLDN10 was lower in invasive lepidic predominant adenocarcinoma than in lung adenocarcioma in situ. Overexpression of CLDN1 and CLDN10 indicates a favorable prognosis in some patients with lung adenocarcinoma.
    Title: Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma.
  6. Claudin 10 expression was down-regulated in gastric cancer.
    Title: The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues.
  7. In claudin-10b, the F66L mutant reduced cation selectivity, and the F66A mutant lost pore conductance
    Title: Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b.
  8. Claudin 10/18 are most commonly expressed in lung adenocarcinomas. Female patients and non-smokers express these claudins more commonly suggesting that they may play a part in the carcinogenesis of tobacco unrelated carcinoma.
    Title: Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers.
  9. Claudin 10 protein is highly expressed in hepatocellular carcinoma (HCC) tissue and is closely related to angiogenesis. It could be a useful marker to predict poor prognosis of HCC patients after hepatectomy.
    Title: Expression of claudin 10 protein in hepatocellular carcinoma: impact on survival.
  10. CLDN10 is a novel biomarker for detecting ovarian cancer in the chicken, a suitable animal model for investigating the effect and function of CLDN in human ovarian cancer.
    Title: Claudin 10 is a glandular epithelial marker in the chicken model as human epithelial ovarian cancer.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
HELIX SYNDROME
MedGen: C4522164 OMIM: 617671 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein claudin 10 (CLDN10), which co-localizes with Nef mainly in the tight junction region and at the vesicular structures PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell junction organization, organism-specific biosystem (from REACTOME)
    Cell junction organization, organism-specific biosystem
    Cell junction organization
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
    Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction interactions, organism-specific biosystem (from REACTOME)
    Tight junction interactions, organism-specific biosystemTight junctions (TJs) are the most apical component of the epithelial junctional complex forming a belt-like structure at the cellular junction. When visualized by freeze-fracture electron microscopy...

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
  
regulation of ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
  
cytoplasm IEA
Inferred from Electronic Annotation
more info
  
integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
claudin-10
Names
OSP-like protein
oligodendrocyte-specific protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047100.1 RefSeqGene

    Range
    5001..151158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160100.1 → NP_001153572.1  claudin-10 isoform a_i1

    See identical proteins and their annotated locations for NP_001153572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a_v1) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. The resulting isoform (a_i1) lacks an internal segment near the N-terminus, compared to isoform a.
    Source sequence(s)
    AK055855, BG697724, DA636757, DB544708
    UniProtKB/Swiss-Prot
    P78369
    Conserved Domains (1) summary
    cl21598
    Location:9 → 158
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. NM_006984.5 → NP_008915.1  claudin-10 isoform b precursor

    See identical proteins and their annotated locations for NP_008915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR and 5' coding region, representing use of an alternate promoter, compared to variant a. The resulting isoform (b) has a longer and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK055855, AL139376, BC010920, BG697724, DA133712, DB544708
    Consensus CDS
    CCDS9476.1
    UniProtKB/Swiss-Prot
    P78369
    Related
    ENSP00000299339.2, ENST00000299339.3
    Conserved Domains (1) summary
    pfam00822
    Location:4 → 179
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  3. NM_182848.3 → NP_878268.1  claudin-10 isoform a

    See identical proteins and their annotated locations for NP_878268.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AK055855, BG697724, DA636757, DB544708
    Consensus CDS
    CCDS9475.1
    UniProtKB/Swiss-Prot
    P78369
    Related
    ENSP00000366069.2, ENST00000376873.7
    Conserved Domains (1) summary
    cl21598
    Location:9 → 177
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    95433588..95579759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020843.1 → XP_016876332.1  claudin-10 isoform X1

    Conserved Domains (1) summary
    cl21598
    Location:9 → 219
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. XM_017020844.1 → XP_016876333.1  claudin-10 isoform X3

    Conserved Domains (1) summary
    cl21598
    Location:9 → 207
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  3. XM_011521134.2 → XP_011519436.1  claudin-10 isoform X2

    See identical proteins and their annotated locations for XP_011519436.1

    Conserved Domains (1) summary
    cl21598
    Location:4 → 209
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  4. XM_024449432.1 → XP_024305200.1  claudin-10 isoform X4

    Conserved Domains (1) summary
    cl21598
    Location:1 → 97
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P78369.2 GenPept UniProtKB/Swiss-Prot:P78369

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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