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CLDN10 claudin 10 [ Homo sapiens (human) ]

Gene ID: 9071, updated on 12-Oct-2019

Summary

Official Symbol
CLDN10provided by HGNC
Official Full Name
claudin 10provided by HGNC
Primary source
HGNC:HGNC:2033
See related
Ensembl:ENSG00000134873 MIM:617579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSPL; HELIX; OSP-L; CPETRL3
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]
Expression
Biased expression in kidney (RPKM 32.5), salivary gland (RPKM 18.3) and 4 other tissues See more
Orthologs

Genomic context

See CLDN10 in Genome Data Viewer
Location:
13q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (95433588..95579759)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96085853..96232010)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370321 Neighboring gene mediator of cell motility 1 pseudogene 5 Neighboring gene CLDN10 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 5370 Neighboring gene Sharpr-MPRA regulatory region 2339 Neighboring gene DAZ interacting zinc finger protein 1 Neighboring gene DNAJC3 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein claudin 10 (CLDN10), which co-localizes with Nef mainly in the tight junction region and at the vesicular structures PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell junction organization, organism-specific biosystem (from REACTOME)
    Cell junction organization, organism-specific biosystem
    Cell junction organization
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
    Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction interactions, organism-specific biosystem (from REACTOME)
    Tight junction interactions, organism-specific biosystemTight junctions (TJs) are the most apical component of the epithelial junctional complex forming a belt-like structure at the cellular junction. When visualized by freeze-fracture electron microscopy...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
claudin-10
Names
OSP-like protein
oligodendrocyte-specific protein-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047100.1 RefSeqGene

    Range
    5001..151158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160100.1NP_001153572.1  claudin-10 isoform a_i1

    See identical proteins and their annotated locations for NP_001153572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a_v1) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. The resulting isoform (a_i1) lacks an internal segment near the N-terminus, compared to isoform a.
    Source sequence(s)
    AK055855, BG697724, DA636757, DB544708
    UniProtKB/Swiss-Prot
    P78369
    Conserved Domains (1) summary
    cl21598
    Location:9158
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  2. NM_006984.5NP_008915.1  claudin-10 isoform b precursor

    See identical proteins and their annotated locations for NP_008915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR and 5' coding region, representing use of an alternate promoter, compared to variant a. The resulting isoform (b) has a longer and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK055855, AL139376, BC010920, BG697724, DA133712, DB544708
    Consensus CDS
    CCDS9476.1
    UniProtKB/Swiss-Prot
    P78369
    Related
    ENSP00000299339.2, ENST00000299339.3
    Conserved Domains (1) summary
    pfam00822
    Location:4179
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  3. NM_182848.3NP_878268.1  claudin-10 isoform a

    See identical proteins and their annotated locations for NP_878268.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AK055855, BG697724, DA636757, DB544708
    Consensus CDS
    CCDS9475.1
    UniProtKB/Swiss-Prot
    P78369
    Related
    ENSP00000366069.2, ENST00000376873.7
    Conserved Domains (1) summary
    cl21598
    Location:9177
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    95433588..95579759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020843.1XP_016876332.1  claudin-10 isoform X1

    Conserved Domains (1) summary
    cl21598
    Location:9219
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  2. XM_017020844.1XP_016876333.1  claudin-10 isoform X3

    Conserved Domains (1) summary
    cl21598
    Location:9207
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  3. XM_011521134.2XP_011519436.1  claudin-10 isoform X2

    See identical proteins and their annotated locations for XP_011519436.1

    Conserved Domains (1) summary
    cl21598
    Location:4209
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  4. XM_024449432.1XP_024305200.1  claudin-10 isoform X4

    Conserved Domains (1) summary
    cl21598
    Location:197
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
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