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ZNF439 zinc finger protein 439 [ Homo sapiens (human) ]

Gene ID: 90594, updated on 5-Jan-2022

Summary

Official Symbol
ZNF439provided by HGNC
Official Full Name
zinc finger protein 439provided by HGNC
Primary source
HGNC:HGNC:20873
See related
Ensembl:ENSG00000171291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in lymph node (RPKM 4.2), skin (RPKM 4.0) and 25 other tissues See more
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Genomic context

See ZNF439 in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11848726..11869486)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11959541..11980301)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 440 Neighboring gene vomeronasal 2 receptor 13 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10901 Neighboring gene vomeronasal 2 receptor 14 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp571K0837

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348718.2NP_001335647.1  zinc finger protein 439 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC008543, AC020951
    Conserved Domains (3) summary
    COG5048
    Location:321492
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:392412
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2667
    KRAB; KRAB box
  2. NM_001348719.2NP_001335648.1  zinc finger protein 439 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC008543, AC020951
    Related
    ENSP00000506930.1, ENST00000682736.1
    Conserved Domains (3) summary
    COG5048
    Location:318489
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:389409
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2364
    KRAB; KRAB box
  3. NM_001348720.2NP_001335649.1  zinc finger protein 439 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform d.
    Source sequence(s)
    AC008543, AC020951
    Conserved Domains (3) summary
    COG5048
    Location:300471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:371391
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  4. NM_001348721.2NP_001335650.1  zinc finger protein 439 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform d.
    Source sequence(s)
    AC008543, AC020951
    Conserved Domains (3) summary
    COG5048
    Location:300471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:371391
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  5. NM_001348722.2NP_001335651.1  zinc finger protein 439 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform e.
    Source sequence(s)
    AC008543, AC020951
    Conserved Domains (2) summary
    COG5048
    Location:277437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:337357
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001348723.2NP_001335652.1  zinc finger protein 439 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform e.
    Source sequence(s)
    AC008543, AC020951
    Conserved Domains (2) summary
    COG5048
    Location:277437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:337357
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001348724.2NP_001335653.1  zinc finger protein 439 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform f.
    Source sequence(s)
    AC008543, AC020951
    Consensus CDS
    CCDS86705.1
    UniProtKB/Swiss-Prot
    Q8NDP4
    UniProtKB/TrEMBL
    A0A0C4DG37
    Related
    ENSP00000395632.1, ENST00000455282.1
    Conserved Domains (2) summary
    COG5048
    Location:177348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248268
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001348725.2NP_001335654.1  zinc finger protein 439 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform f.
    Source sequence(s)
    AC008543, AC020951
    Consensus CDS
    CCDS86705.1
    UniProtKB/Swiss-Prot
    Q8NDP4
    UniProtKB/TrEMBL
    A0A0C4DG37
    Conserved Domains (2) summary
    COG5048
    Location:177348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248268
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_152262.3NP_689475.1  zinc finger protein 439 isoform c

    See identical proteins and their annotated locations for NP_689475.1

    Status: VALIDATED

    Source sequence(s)
    AC020951
    Consensus CDS
    CCDS12268.1
    UniProtKB/Swiss-Prot
    Q8NDP4
    Related
    ENSP00000305077.2, ENST00000304030.2
    Conserved Domains (5) summary
    smart00349
    Location:1961
    KRAB; krueppel associated box
    COG5048
    Location:313484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:384404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1958
    KRAB; KRAB box
    pfam13465
    Location:368393
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    11848726..11869486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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