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ZNF700 zinc finger protein 700 [ Homo sapiens (human) ]

Gene ID: 90592, updated on 23-Nov-2021

Summary

Official Symbol
ZNF700provided by HGNC
Official Full Name
zinc finger protein 700provided by HGNC
Primary source
HGNC:HGNC:25292
See related
Ensembl:ENSG00000196757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in skin (RPKM 8.1), bone marrow (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF700 in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11925107..11950763)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12035922..12061578)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 69 Neighboring gene zinc finger protein 440-like Neighboring gene vomeronasal 2 receptor 15 pseudogene Neighboring gene vomeronasal 2 receptor 21 pseudogene Neighboring gene Sharpr-MPRA regulatory region 6121 Neighboring gene zinc finger protein 763

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Potential readthrough

Included gene: ZNF763

Homology

Clone Names

  • DKFZp434I1610

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271848.2NP_001258777.1  zinc finger protein 700 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AL136732, DA794204, DB013169
    Consensus CDS
    CCDS74289.1
    UniProtKB/Swiss-Prot
    Q9H0M5
    UniProtKB/TrEMBL
    A0A087WVH9
    Related
    ENSP00000479449.1, ENST00000622593.4
    Conserved Domains (5) summary
    smart00349
    Location:2769
    KRAB; krueppel associated box
    COG5048
    Location:224636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:569589
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:581606
    zf-H2C2_2; Zinc-finger double domain
  2. NM_144566.3NP_653167.1  zinc finger protein 700 isoform 1

    See identical proteins and their annotated locations for NP_653167.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AL136732
    Consensus CDS
    CCDS32915.1
    UniProtKB/Swiss-Prot
    Q9H0M5
    Related
    ENSP00000254321.4, ENST00000254321.10
    Conserved Domains (5) summary
    smart00349
    Location:2466
    KRAB; krueppel associated box
    COG5048
    Location:221633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:566586
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2463
    KRAB; KRAB box
    pfam13465
    Location:578603
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    11925107..11950763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001271847.1: Suppressed sequence

    Description
    NM_001271847.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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