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ZNF700 zinc finger protein 700 [ Homo sapiens (human) ]

Gene ID: 90592, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF700provided by HGNC
Official Full Name
zinc finger protein 700provided by HGNC
Primary source
HGNC:HGNC:25292
See related
Ensembl:ENSG00000196757 AllianceGenome:HGNC:25292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in skin (RPKM 8.1), bone marrow (RPKM 7.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF700 in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11925107..11950763)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12053315..12078973)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12035922..12061578)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 69 Neighboring gene zinc finger protein 440-like Neighboring gene vomeronasal 2 receptor 15 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12033828-12034618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12034619-12035408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12035565-12036137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10135 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:12060504-12060733 Neighboring gene vomeronasal 2 receptor 21 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12074983-12075936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10136 Neighboring gene zinc finger protein 763

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer. O'Reilly JA, et al. PLoS One, 2015. PMID 25875936, Free PMC Article
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Wiemann S, et al. Genome Res, 2001 Mar. PMID 11230166, Free PMC Article
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High ZNF700 expression is associated with colorectal cancer.
    Title: Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Potential readthrough

Included gene: ZNF763

Homology

Clone Names

  • DKFZp434I1610

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 700

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271848.2 → NP_001258777.1  zinc finger protein 700 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AL136732, DA794204, DB013169
    Consensus CDS
    CCDS74289.1
    UniProtKB/TrEMBL
    A0A087WVH9
    Related
    ENSP00000479449.1, ENST00000622593.4
    Conserved Domains (5) summary
    smart00349
    Location:27 → 69
    KRAB; krueppel associated box
    COG5048
    Location:224 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:569 → 589
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:27 → 66
    KRAB; KRAB box
    pfam13465
    Location:581 → 606
    zf-H2C2_2; Zinc-finger double domain

  2. NM_144566.3 → NP_653167.1  zinc finger protein 700 isoform 1

    See identical proteins and their annotated locations for NP_653167.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AL136732
    Consensus CDS
    CCDS32915.1
    UniProtKB/Swiss-Prot
    B9EGU4, Q9H0M5
    Related
    ENSP00000254321.4, ENST00000254321.10
    Conserved Domains (5) summary
    smart00349
    Location:24 → 66
    KRAB; krueppel associated box
    COG5048
    Location:221 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:566 → 586
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:24 → 63
    KRAB; KRAB box
    pfam13465
    Location:578 → 603
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11925107..11950763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12053315..12078973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001271847.1: Suppressed sequence

    Description
    NM_001271847.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H0M5.1 GenPept UniProtKB/Swiss-Prot:Q9H0M5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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