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ZNF468 zinc finger protein 468 [ Homo sapiens (human) ]

Gene ID: 90333, updated on 11-Jun-2021

Summary

Official Symbol
ZNF468provided by HGNC
Official Full Name
zinc finger protein 468provided by HGNC
Primary source
HGNC:HGNC:33105
See related
Ensembl:ENSG00000204604 MIM:616841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 9.6), placenta (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF468 in Genome Data Viewer
Location:
19q13.41
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52838010..52857619, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53341263..53360872, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 600 Neighboring gene zinc finger protein 28 Neighboring gene PABPN1 pseudogene 2 Neighboring gene zinc finger protein 320 Neighboring gene zinc finger protein 888 Neighboring gene ZNF816-ZNF321P readthrough Neighboring gene zinc finger protein 321, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781B1474, DKFZp781N07108

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 468
Names
zinc finger protein ZNF468

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008801.2NP_001008801.1  zinc finger protein 468 isoform 2

    See identical proteins and their annotated locations for NP_001008801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AC008813, AK025501, AY442330, BC037409
    Consensus CDS
    CCDS33094.1
    UniProtKB/Swiss-Prot
    Q5VIY5
    Related
    ENSP00000470381.1, ENST00000595646.6
    Conserved Domains (6) summary
    smart00349
    Location:848
    KRAB; krueppel associated box
    COG5048
    Location:305478
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:357377
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:299321
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:313338
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001277120.2NP_001264049.1  zinc finger protein 468 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) includes an additional internal exon that results in a frameshifted 3' coding region, compared to variant 2. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 2.
    Source sequence(s)
    AC008813, AK025501, AY442331, BC037409
    Consensus CDS
    CCDS62781.1
    UniProtKB/Swiss-Prot
    Q5VIY5
    Related
    ENSP00000243639.4, ENST00000243639.8
    Conserved Domains (3) summary
    smart00349
    Location:849
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13900
    Location:5287
    GVQW; Putative domain of unknown function

RNA

  1. NR_102299.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes two additional internal exons, compared to variant 2. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008813, AK025501, AY442331, BC037409, DA245284
  2. NR_102300.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes two additional internal exons, compared to variant 2. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008813, AK025501, AY442331, BC037409, BX501408
  3. NR_102301.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an additional exon in the 5' region, compared to variant 2. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008813, AK025501, AY442331, BC037409, DB234532

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52838010..52857619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027443.1XP_016882932.1  zinc finger protein 468 isoform X1

  2. XM_017027444.1XP_016882933.1  zinc finger protein 468 isoform X2

    UniProtKB/Swiss-Prot
    Q5VIY5
    Conserved Domains (4) summary
    COG5048
    Location:252425
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:304324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:246268
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:260285
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199132.1: Suppressed sequence

    Description
    NM_199132.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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