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TSPAN18 tetraspanin 18 [ Homo sapiens (human) ]

Gene ID: 90139, updated on 5-Aug-2018

Summary

Official Symbol
TSPAN18provided by HGNC
Official Full Name
tetraspanin 18provided by HGNC
Primary source
HGNC:HGNC:20660
See related
Ensembl:ENSG00000157570 Vega:OTTHUMG00000163883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSPAN
Expression
Broad expression in heart (RPKM 27.7), adrenal (RPKM 13.4) and 21 other tissues See more
Orthologs

Genomic context

See TSPAN18 in Genome Data Viewer
Location:
11p11.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (44727139..44932427)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (44748731..44953978)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L34 pseudogene 22 Neighboring gene uncharacterized LOC105376647 Neighboring gene tumor protein p53 inducible protein 11 Neighboring gene uncharacterized LOC105376649 Neighboring gene uncharacterized LOC221122 Neighboring gene uncharacterized LOC105376650

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of tetraspanin 18 (TSPAN18) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14609

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetraspanin-18
Names
tspan-18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130783.4NP_570139.3  tetraspanin-18

    See identical proteins and their annotated locations for NP_570139.3

    Status: VALIDATED

    Source sequence(s)
    AC092733, AK075547, AY358087, BF110241, DA067480, DA603407, DA734054
    Consensus CDS
    CCDS7910.1
    UniProtKB/Swiss-Prot
    Q96SJ8
    Related
    ENSP00000339820.3, ENST00000340160.7
    Conserved Domains (1) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    44727139..44932427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520459.3XP_011518761.1  tetraspanin-18 isoform X2

    See identical proteins and their annotated locations for XP_011518761.1

    UniProtKB/Swiss-Prot
    Q96SJ8
    Related
    ENSP00000429993.2, OTTHUMP00000225273, ENST00000520358.6
    Conserved Domains (1) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  2. XM_017018530.1XP_016874019.1  tetraspanin-18 isoform X3

  3. XM_017018531.1XP_016874020.1  tetraspanin-18 isoform X4

  4. XM_005253217.3XP_005253274.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_005253274.1

    Conserved Domains (1) summary
    cd03156
    Location:115228
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  5. XM_006718373.4XP_006718436.1  tetraspanin-18 isoform X2

    See identical proteins and their annotated locations for XP_006718436.1

    UniProtKB/Swiss-Prot
    Q96SJ8
    Conserved Domains (1) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  6. XM_006718372.3XP_006718435.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006718435.1

    Conserved Domains (1) summary
    cd03156
    Location:115228
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001031730.1: Suppressed sequence

    Description
    NM_001031730.1: This RefSeq was permanently suppressed because the transcript is 5' partial, and its full-length nature is unknown.
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