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Tspan18 tetraspanin 18 [ Mus musculus (house mouse) ]

Gene ID: 241556, updated on 30-Apr-2024

Summary

Official Symbol
Tspan18provided by MGI
Official Full Name
tetraspanin 18provided by MGI
Primary source
MGI:MGI:1917186
See related
Ensembl:ENSMUSG00000027217 AllianceGenome:MGI:1917186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720430O15; 2610042G18Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human TSPAN18 (tetraspanin 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 39.7), adrenal adult (RPKM 19.1) and 20 other tissues See more
Orthologs
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Genomic context

See Tspan18 in Genome Data Viewer
Location:
2 E1; 2 51.37 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (93032105..93164898, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (93201760..93334551, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93032831-93033064 Neighboring gene predicted gene, 32683 Neighboring gene transformation related protein 53 inducible protein 11 Neighboring gene predicted gene, 32824 Neighboring gene predicted gene, 39882 Neighboring gene VISTA enhancer mm1603 Neighboring gene predicted gene, 39881 Neighboring gene predicted gene, 32745 Neighboring gene predicted gene 13807

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General protein information

Preferred Names
tetraspanin-18
Names
tspan-18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183180.2NP_899003.1  tetraspanin-18

    See identical proteins and their annotated locations for NP_899003.1

    Status: VALIDATED

    Source sequence(s)
    AL691472, BB659903, BC052169
    Consensus CDS
    CCDS38182.1
    UniProtKB/Swiss-Prot
    Q80WR1
    Related
    ENSMUSP00000106896.3, ENSMUST00000111265.9
    Conserved Domains (2) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10243
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    93032105..93164898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499475.5XP_006499538.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006499538.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Conserved Domains (2) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10243
    Tetraspannin; Tetraspanin family
  2. XM_006499476.5XP_006499539.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006499539.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Conserved Domains (2) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10243
    Tetraspannin; Tetraspanin family
  3. XM_006499474.5XP_006499537.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006499537.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Conserved Domains (2) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10243
    Tetraspannin; Tetraspanin family
  4. XM_011239525.3XP_011237827.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_011237827.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Conserved Domains (2) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10243
    Tetraspannin; Tetraspanin family
  5. XM_006499477.5XP_006499540.1  tetraspanin-18 isoform X1

    See identical proteins and their annotated locations for XP_006499540.1

    UniProtKB/Swiss-Prot
    Q80WR1
    Related
    ENSMUSP00000028646.3, ENSMUST00000028646.4
    Conserved Domains (2) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10243
    Tetraspannin; Tetraspanin family