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CCNB1 cyclin B1 [ Homo sapiens (human) ]

Gene ID: 891, updated on 21-Jun-2020

Summary

Official Symbol
CCNB1provided by HGNC
Official Full Name
cyclin B1provided by HGNC
Primary source
HGNC:HGNC:1579
See related
Ensembl:ENSG00000134057 MIM:123836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCNB
Summary
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017]
Expression
Broad expression in lymph node (RPKM 19.4), testis (RPKM 14.8) and 21 other tissues See more
Orthologs

Genomic context

See CCNB1 in Genome Data Viewer
Location:
5q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (69167010..69178245)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68462837..68474072)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 5 Neighboring gene small nucleolar RNA, H/ACA box 50D Neighboring gene uncharacterized LOC112267932 Neighboring gene Sharpr-MPRA regulatory region 51 Neighboring gene centromere protein H

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cell-cell contact between T cells expressing HIV-1 gp120/gp41 and other T cells expressing CD4 receptors leads to the rapid accumulation of cyclin B and tyrosine-hyperphosphorylated p34cdc2 (cdk1) kinase, indicative of cell cycle arrest at G2 phase PubMed
Tat tat HIV-1 Tat stimulates polyubiquitination-mediated degradation of cyclin B1 through binding to the N-terminal of cyclin B1 (amino acids 61-129) that is just downstream of the D box PubMed
tat HIV-1 Tat forms a quaternary complex with Tip60, Plk1, and cyclin B1 to inhibit Plk1-mediated phosphorylation of cyclin B1 at Ser133 position PubMed
tat HIV-1 Tat induces a constitutive overexpression of cyclin B1 protein in human rhabdomyosarcoma cells PubMed
Vif vif HIV-1 Vif-mediated G2 arrest involves the dysregulation of CDK1-CyclinB1 nuclear translocation PubMed
Vpr vpr HIV-1 Vpr upregulates CCNB1 in HeLa cells within 12 hours of exposure PubMed
vpr HIV-1 Vpr induces accumulation of the G2 cell cycle protein cyclin B1 and activation of caspase-3 and caspase-9 in multidrug-resistant human colorectal cancer cells PubMed
vpr HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta PubMed
vpr Vpr-induced cell cycle G2/M arrest reveals a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 theta PubMed
vpr Rupture of HIV-1 Vpr-induced nuclear envelope herniations produces transient loss of the subcellular compartmentalization of Wee1, Cdc25C, cyclin B1, and presumably other soluble cellular components, resulting in their release into the cytoplasm PubMed
vpr The human Vpr interacting protein (hVIP/MOV34) is a likely cellular cofactor for HIV-1 Vpr inactivation of the cdc2-cyclin B kinase complex and induction of cell cycle arrest PubMed
vpr Data suggests that HIV-1 Vpr transactivation of the HIV-LTR promoter occurs through the inhibition of p300-associated cdc2-cyclin B kinase complex activity which enhances transcriptional activation by Rel A and p300 PubMed
vpr Inactivation of the cdc2-cyclin B kinase complex by HIV-1 Vpr leads to the activation of Poly(A) polymerase PubMed
vpr Inactivation of the cdc2-cyclin B kinase complex and arrest in the G2 phase of the cell cycle has been mapped to the C-terminus of HIV-1 Vpr, including amino acids 73, 80 and 84-96 PubMed
vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inactivating cdc25C, the phosphatase that dephosphorylates and activates cdc2 PubMed
vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inhibiting the dephosphorylation of cdc2 tyrosine 15, leading to arrest in the G2 phase of the cell cycle PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone kinase activity IEA
Inferred from Electronic Annotation
more info
 
patched binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to iron(III) ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
digestive tract development IEA
Inferred from Electronic Annotation
more info
 
histone H3-S10 phosphorylation involved in chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic metaphase plate congression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear envelope disassembly TAS
Traceable Author Statement
more info
 
mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial ATP synthesis coupled electron transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle TAS
Traceable Author Statement
more info
 
regulation of chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to DDT IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
ventricular cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed nuclear chromosome outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
cyclin B1-CDK1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin B1-CDK1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G2/mitotic-specific cyclin-B1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354844.1NP_001341773.1  G2/mitotic-specific cyclin-B1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC010273, AC022107, BT020128
    Related
    ENSP00000424588.1, ENST00000505500.5
    Conserved Domains (1) summary
    cl25647
    Location:154394
    Cyclin_N2; N-terminal region of cyclin_N
  2. NM_001354845.1NP_001341774.1  G2/mitotic-specific cyclin-B1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC010273, AC022107
    Conserved Domains (2) summary
    pfam00134
    Location:179245
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:247365
    Cyclin_C; Cyclin, C-terminal domain
  3. NM_031966.4NP_114172.1  G2/mitotic-specific cyclin-B1 isoform 1

    See identical proteins and their annotated locations for NP_114172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC010273, AI972071, BC006510, BI253686, BM979016
    Consensus CDS
    CCDS3997.1
    UniProtKB/Swiss-Prot
    P14635
    Related
    ENSP00000256442.5, ENST00000256442.10
    Conserved Domains (2) summary
    pfam00134
    Location:173298
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:300418
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    69167010..69178245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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