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Ccnb1 cyclin B1 [ Mus musculus (house mouse) ]

Gene ID: 268697, updated on 17-Jan-2023

Summary

Official Symbol
Ccnb1provided by MGI
Official Full Name
cyclin B1provided by MGI
Primary source
MGI:MGI:88302
See related
Ensembl:ENSMUSG00000041431 AllianceGenome:MGI:88302
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CycB1; Cycb-4; Cycb-5; Ccnb1-rs1; Cycb1-rs1; Ccnb1-rs13
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; enzyme binding activity; and patched binding activity. Acts upstream of or within several processes, including histone H3-S10 phosphorylation involved in chromosome condensation; in utero embryonic development; and positive regulation of fibroblast proliferation. Located in cytoplasm; membrane; and nucleus. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 79.4), liver E14.5 (RPKM 71.8) and 11 other tissues See more
Orthologs
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Genomic context

See Ccnb1 in Genome Data Viewer
Location:
13 D1; 13 53.23 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100915247..100922994, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100778739..100786486, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene centromere protein H Neighboring gene solute carrier family 30 (zinc transporter), member 5 Neighboring gene predicted gene, 41040

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC18763, MGC90915

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables patched binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic metaphase plate congression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in oocyte maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial ATP synthesis coupled electron transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromosome condensation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin B1-CDK1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin B1-CDK1 complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G2/mitotic-specific cyclin-B1
Names
cyclin B1, related sequence 1
cyclin B1, related sequence 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172301.3NP_758505.2  G2/mitotic-specific cyclin-B1

    See identical proteins and their annotated locations for NP_758505.2

    Status: PROVISIONAL

    Source sequence(s)
    AC112701
    Consensus CDS
    CCDS36768.1
    UniProtKB/Swiss-Prot
    P24860
    UniProtKB/TrEMBL
    Q3TQW9
    Related
    ENSMUSP00000071989.9, ENSMUST00000072119.15
    Conserved Domains (2) summary
    pfam00134
    Location:170295
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:297415
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100915247..100922994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)