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CCNA1 cyclin A1 [ Homo sapiens (human) ]

Gene ID: 8900, updated on 3-Apr-2024

Summary

Official Symbol
CCNA1provided by HGNC
Official Full Name
cyclin A1provided by HGNC
Primary source
HGNC:HGNC:1577
See related
Ensembl:ENSG00000133101 MIM:604036; AllianceGenome:HGNC:1577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT146
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 24.4) See more
Orthologs
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Genomic context

See CCNA1 in Genome Data Viewer
Location:
13q13.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (36431517..36442870)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (35651206..35662375)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (37006092..37017007)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene CCDC169-SOHLH2 readthrough Neighboring gene coiled-coil domain containing 169 Neighboring gene Sharpr-MPRA regulatory region 14903 Neighboring gene RNA, U6 small nuclear 71, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:36871578-36872539 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:36872540-36873502 Neighboring gene NANOG hESC enhancer GRCh37_chr13:36887598-36888362 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:36890200-36891034 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:36891035-36891868 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:36894061-36894764 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:36895467-36896169 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:36896170-36896871 Neighboring gene Sharpr-MPRA regulatory region 3304 Neighboring gene spartin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5263 Neighboring gene SPART antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:36962882-36963065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5266 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:37011626-37012825 Neighboring gene H2AC histone family pseudogene 1 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr13:37101466-37101966 Neighboring gene uncharacterized LOC124903155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
Vif vif HIV-1 Vif upregulates the expression of cyclin A1 (CCNA1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in male meiosis I TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cyclin A1-CDK2 complex IEA
Inferred from Electronic Annotation
more info
 
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cyclin-A1
Names
testicular tissue protein Li 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111045.4NP_001104515.2  cyclin-A1

    Status: REVIEWED

    Source sequence(s)
    AL359767
    Related
    ENSP00000486017.2, ENST00000625767.2
  2. NM_001111046.2NP_001104516.1  cyclin-A1

    See identical proteins and their annotated locations for NP_001104516.1

    Status: REVIEWED

    Source sequence(s)
    CD171793, U66838
    Consensus CDS
    CCDS45031.1
    UniProtKB/TrEMBL
    A0A140VJG0
    Related
    ENSP00000400666.1, ENST00000440264.5
    Conserved Domains (2) summary
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  3. NM_001111047.2NP_001104517.1  cyclin-A1

    See identical proteins and their annotated locations for NP_001104517.1

    Status: REVIEWED

    Source sequence(s)
    BC036346, DC395631
    Consensus CDS
    CCDS45031.1
    UniProtKB/TrEMBL
    A0A140VJG0
    Conserved Domains (2) summary
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  4. NM_001413923.1NP_001400852.1  cyclin-A1

    Status: REVIEWED

    Source sequence(s)
    AL359767
    Related
    ENSP00000255465.5, ENST00000255465.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    36431517..36442870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535294.3XP_011533596.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_011533596.1

    UniProtKB/TrEMBL
    A0A140VJG0
    Related
    ENSP00000486482.1, ENST00000630422.2
    Conserved Domains (2) summary
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  2. XM_011535295.3XP_011533597.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_011533597.1

    UniProtKB/TrEMBL
    A0A140VJG0
    Conserved Domains (2) summary
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  3. XM_011535296.3XP_011533598.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_011533598.1

    UniProtKB/TrEMBL
    A0A140VJG0
    Conserved Domains (2) summary
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    35651206..35662375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375156.1XP_054231131.1  cyclin-A1 isoform X1

  2. XM_054375155.1XP_054231130.1  cyclin-A1 isoform X1

  3. XM_054375154.1XP_054231129.1  cyclin-A1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003914.4: Suppressed sequence

    Description
    NM_003914.4: This RefSeq was removed because currently there is insufficient support for the translation start site.