CCNA1 cyclin A1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCNA1provided by HGNC
Official Full Name: cyclin A1provided by HGNC
Primary source: HGNC:HGNC:1577
See related: Ensembl:ENSG00000133101 MIM:604036
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT146
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward testis (RPKM 24.4) See more
Orthologs: mouse all

Genomic context

Location:: 13q13.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109.20191205	current	GRCh38.p13 (GCF_000001405.39)	13	NC_000013.11 (36430488..36442882)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (37005257..37017019)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00304 can significantly promote CCNA1 expression in PCa cells.
Title: Androgen-responsive lncRNA LINC00304 promotes cell cycle and proliferation via regulating CCNA1.
DUB3 functions as a novel cyclin A regulator through maintaining cyclin A stability.
Title: Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells.
Thus, Cyclin A/Cdk1 phosphorylation primes MYPT1 for Plk1 binding. These data demonstrate cross-regulation between Cyclin A/Cdk1-dependent and Plk1-dependent phosphorylation of substrates during mitosis to ensure efficient correction of kinetochore microtubule attachment errors necessary for high mitotic fidelity.
Title: Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.
Cyclin A1 functions as an oncogene that controls proliferative and survival activities in tumourigenesis and chemoresistance of ovarian cancer.
Title: Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells.
In the bone marrow, cyclin A1 and aromatase enhanced local bone marrow-releasing factors, including androgen receptor, estrogen and matrix metalloproteinase MMP9 and promoted the metastatic growth of prostate cancer cells
Title: Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow.
The data showed that E7 induced CCNA1 methylation by forming a complex with Dnmt1 at the CCNA1 promoter, resulting in the subsequent reduction of expression in cancers.
Title: Human papillomavirus type 16 E7 oncoprotein mediates CCNA1 promoter methylation.
DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors.
Title: DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors.
These data from results indicated a significant connection of CCNA1 methylation with poor progression in human malignant tumors among both Caucasian and Asian populations.
Title: Correlation of CCNA1 promoter methylation with malignant tumors: a meta-analysis introduction.
Cyclin A1 immunoexpression is of potential utility in predicting disease progression in patients with pT1 urothelial carcinomas of the bladder
Title: Cyclin A1 expression predicts progression in pT1 urothelial carcinoma of bladder: a tissue microarray study of 149 patients treated by transurethral resection.
HS3ST2 and CCNA1 genes may play important roles in HPV-induced cervical cancer and patients with specific hypermethylated genes may have a greater risk of progressing to invasive cervical cancer.
Title: Methylation in the promoters of HS3ST2 and CCNA1 genes is associated with cervical cancer in Uygur women in Xinjiang.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA	PubMed
Vif	vif	HIV-1 Vif upregulates the expression of cyclin A1 (CCNA1) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44746 (e-PCR)
- UniSTS:3713

PMC193706P2 (e-PCR)
- UniSTS:271757

RH71252 (e-PCR)
- UniSTS:63977

RH25577 (e-PCR)
- UniSTS:83702

Homology

Homologs of the CCNA1 gene: The CCNA1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 304 organisms have orthologs with human gene CCNA1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
cell division	IEA Inferred from Electronic Annotation more info
male meiosis I	TAS Traceable Author Statement more info	PubMed
mitotic cell cycle phase transition	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein deubiquitination	TAS Traceable Author Statement more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of transcription involved in G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info
spermatogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cyclin A1-CDK2 complex	IEA Inferred from Electronic Annotation more info
cyclin A2-CDK2 complex	IDA Inferred from Direct Assay more info	PubMed
cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytosol	TAS Traceable Author Statement more info	PubMed
microtubule cytoskeleton	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: cyclin-A1

Names: testicular tissue protein Li 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111045.1 → NP_001104515.1 cyclin-A1 isoform b

See identical proteins and their annotated locations for NP_001104515.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a protein (isoform b) that is 1 amino acid shorter than isoform a.

Source sequence(s)

AA553454, BC036346, DC396283, DC411883

Consensus CDS

CCDS45030.1

UniProtKB/Swiss-Prot

P78396

UniProtKB/TrEMBL

A0A140VJG0

Related

ENSP00000486017.1, ENST00000625767.1

Conserved Domains (3) summary

pfam00134
Location:213 → 339

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:341 → 458

Cyclin_C; Cyclin, C-terminal domain

pfam16500
Location:70 → 144

Cyclin_N2; N-terminal region of cyclin_N
NM_001111046.1 → NP_001104516.1 cyclin-A1 isoform c

See identical proteins and their annotated locations for NP_001104516.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. Transcript variants 3 and 4 encode isoform c, which has a shorter N-terminus when compared to isoform a.

Source sequence(s)

AA553454, AL359767, BG723613, CD171793, U66838

Consensus CDS

CCDS45031.1

UniProtKB/Swiss-Prot

P78396

Related

ENSP00000400666.1, ENST00000440264.5

Conserved Domains (2) summary

pfam00134
Location:170 → 296

Cyclin_N; Cyclin, N-terminal domain

cl25647
Location:143 → 410

Cyclin_N2; N-terminal region of cyclin_N
NM_001111047.1 → NP_001104517.1 cyclin-A1 isoform c

See identical proteins and their annotated locations for NP_001104517.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Transcript variants 3 and 4 encode isoform c, which has a shorter N-terminus when compared to isoform a.

Source sequence(s)

AA553454, AL359767, BC036346, BG723613, DC395631

Consensus CDS

CCDS45031.1

UniProtKB/Swiss-Prot

P78396

Conserved Domains (2) summary

pfam00134
Location:170 → 296

Cyclin_N; Cyclin, N-terminal domain

cl25647
Location:143 → 410

Cyclin_N2; N-terminal region of cyclin_N
NM_003914.4 → NP_003905.1 cyclin-A1 isoform a

See identical proteins and their annotated locations for NP_003905.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

DC411883, U66838

Consensus CDS

CCDS9357.1

UniProtKB/Swiss-Prot

P78396

Related

ENSP00000255465.4, ENST00000255465.7

Conserved Domains (3) summary

pfam00134
Location:214 → 340

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:342 → 459

Cyclin_C; Cyclin, C-terminal domain

pfam16500
Location:71 → 145

Cyclin_N2; N-terminal region of cyclin_N