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CCNA1 cyclin A1 [ Homo sapiens (human) ]

Gene ID: 8900, updated on 27-Jan-2020

Summary

Official Symbol
CCNA1provided by HGNC
Official Full Name
cyclin A1provided by HGNC
Primary source
HGNC:HGNC:1577
See related
Ensembl:ENSG00000133101 MIM:604036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT146
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 24.4) See more
Orthologs

Genomic context

See CCNA1 in Genome Data Viewer
Location:
13q13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (36430488..36442882)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (37005257..37017019)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3304 Neighboring gene spartin Neighboring gene SPART antisense RNA 1 Neighboring gene H2AC histone family pseudogene 1 Neighboring gene uncharacterized LOC102723490 Neighboring gene serine rich and transmembrane domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
Vif vif HIV-1 Vif upregulates the expression of cyclin A1 (CCNA1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
male meiosis I TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cyclin A1-CDK2 complex IEA
Inferred from Electronic Annotation
more info
 
cyclin A2-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-A1
Names
testicular tissue protein Li 34

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111045.1NP_001104515.1  cyclin-A1 isoform b

    See identical proteins and their annotated locations for NP_001104515.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a protein (isoform b) that is 1 amino acid shorter than isoform a.
    Source sequence(s)
    AA553454, BC036346, DC396283, DC411883
    Consensus CDS
    CCDS45030.1
    UniProtKB/Swiss-Prot
    P78396
    UniProtKB/TrEMBL
    A0A140VJG0
    Related
    ENSP00000486017.1, ENST00000625767.1
    Conserved Domains (3) summary
    pfam00134
    Location:213339
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:341458
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:70144
    Cyclin_N2; N-terminal region of cyclin_N
  2. NM_001111046.1NP_001104516.1  cyclin-A1 isoform c

    See identical proteins and their annotated locations for NP_001104516.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. Transcript variants 3 and 4 encode isoform c, which has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    AA553454, AL359767, BG723613, CD171793, U66838
    Consensus CDS
    CCDS45031.1
    UniProtKB/Swiss-Prot
    P78396
    Related
    ENSP00000400666.1, ENST00000440264.5
    Conserved Domains (2) summary
    pfam00134
    Location:170296
    Cyclin_N; Cyclin, N-terminal domain
    cl25647
    Location:143410
    Cyclin_N2; N-terminal region of cyclin_N
  3. NM_001111047.1NP_001104517.1  cyclin-A1 isoform c

    See identical proteins and their annotated locations for NP_001104517.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Transcript variants 3 and 4 encode isoform c, which has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    AA553454, AL359767, BC036346, BG723613, DC395631
    Consensus CDS
    CCDS45031.1
    UniProtKB/Swiss-Prot
    P78396
    Conserved Domains (2) summary
    pfam00134
    Location:170296
    Cyclin_N; Cyclin, N-terminal domain
    cl25647
    Location:143410
    Cyclin_N2; N-terminal region of cyclin_N
  4. NM_003914.4NP_003905.1  cyclin-A1 isoform a

    See identical proteins and their annotated locations for NP_003905.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    DC411883, U66838
    Consensus CDS
    CCDS9357.1
    UniProtKB/Swiss-Prot
    P78396
    Related
    ENSP00000255465.4, ENST00000255465.7
    Conserved Domains (3) summary
    pfam00134
    Location:214340
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:342459
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:71145
    Cyclin_N2; N-terminal region of cyclin_N

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    36430488..36442882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535294.2XP_011533596.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_011533596.1

    UniProtKB/Swiss-Prot
    P78396
    Related
    ENSP00000486482.1, ENST00000630422.2
    Conserved Domains (2) summary
    pfam00134
    Location:170296
    Cyclin_N; Cyclin, N-terminal domain
    cl25647
    Location:143410
    Cyclin_N2; N-terminal region of cyclin_N
  2. XM_011535295.2XP_011533597.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_011533597.1

    UniProtKB/Swiss-Prot
    P78396
    Conserved Domains (2) summary
    pfam00134
    Location:170296
    Cyclin_N; Cyclin, N-terminal domain
    cl25647
    Location:143410
    Cyclin_N2; N-terminal region of cyclin_N
  3. XM_011535296.2XP_011533598.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_011533598.1

    UniProtKB/Swiss-Prot
    P78396
    Conserved Domains (2) summary
    pfam00134
    Location:170296
    Cyclin_N; Cyclin, N-terminal domain
    cl25647
    Location:143410
    Cyclin_N2; N-terminal region of cyclin_N
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