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CCNA1 cyclin A1 [ Homo sapiens (human) ]

Gene ID: 8900, updated on 29-Mar-2023

Summary

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Official Symbol
CCNA1provided by HGNC
Official Full Name
cyclin A1provided by HGNC
Primary source
HGNC:HGNC:1577
See related
Ensembl:ENSG00000133101 MIM:604036; AllianceGenome:HGNC:1577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT146
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 24.4) See more
Orthologs
mouse all
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Genomic context

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See CCNA1 in Genome Data Viewer
Location:
13q13.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (36431517..36442870)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (35651206..35662375)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (37006092..37017007)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene spartin Neighboring gene Sharpr-MPRA regulatory region 3304 Neighboring gene SPART antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:37011626-37012825 Neighboring gene H2AC histone family pseudogene 1 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr13:37101466-37101966

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia. Ge M, et al. Cancer Sci, 2021 Jun. PMID 33738896, Free PMC Article
  2. CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer. da Silva RM, et al. Acta Histochem, 2020 Dec. PMID 33007517
  3. Value of CCNA1 promoter methylation in triaging ASC-US cytology. Oranratanaphan S, et al. Asian Pac J Cancer Prev, 2020 Feb 1. PMID 32102526, Free PMC Article
  4. Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells. Akaike Y, et al. Cell Cycle, 2020 Jan. PMID 31760882, Free PMC Article
  5. CCNA1 promoter methylation: a potential marker for grading Papanicolaou smear cervical squamous intraepithelial lesions. Chujan S, et al. Asian Pac J Cancer Prev, 2014. PMID 25292097

See all (159) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histone methyltransferase EZH2 epigenetically affects CCNA1 expression in acute myeloid leukemia.
    Title: Histone methyltransferase EZH2 epigenetically affects CCNA1 expression in acute myeloid leukemia.
  2. The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma.
    Title: The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma.
  3. CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer.
    Title: CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer.
  4. Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia.
    Title: Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia.
  5. Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells.
    Title: Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells.
  6. Expression and prognosis of CyclinA and CDK2 in patients with advanced cervical cancer after chemotherapy.
    Title: Expression and prognosis of CyclinA and CDK2 in patients with advanced cervical cancer after chemotherapy.
  7. Value of CCNA1 promoter methylation in triaging ASC-US cytology.
    Title: Value of CCNA1 promoter methylation in triaging ASC-US cytology.
  8. immunopeptidome of HeLa cells transfected with Cyclin A1 and HLA-A*02:01 revealed six Cyclin A1-derived HLA ligands
    Title: Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo.
  9. Study found the WT1 and CCNA1 mRNA levels to be elevated in bone marrow samples from pediatric acute promyelocytic leukemia patients (APL), and varied in pediatric acute lymphocytic leukemia (ALL) patients. The examination of the CCNA1 promoter identified potential canonical WT1 binding sites within the 3kb region upstream of the transcription start site.
    Title: WT1 regulates cyclin A1 expression in K562 cells.
  10. LINC00304 can significantly promote CCNA1 expression in PCa cells.
    Title: Androgen-responsive lncRNA LINC00304 promotes cell cycle and proliferation via regulating CCNA1.
Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
Vif vif HIV-1 Vif upregulates the expression of cyclin A1 (CCNA1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in male meiosis I TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin A1-CDK2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
cyclin-A1
Names
testicular tissue protein Li 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111045.4 → NP_001104515.2  cyclin-A1

    Status: REVIEWED

    Source sequence(s)
    AL359767
    Related
    ENSP00000486017.1, ENST00000625767.1

  2. NM_001111046.2 → NP_001104516.1  cyclin-A1

    See identical proteins and their annotated locations for NP_001104516.1

    Status: REVIEWED

    Source sequence(s)
    CD171793, U66838
    Consensus CDS
    CCDS45031.1
    UniProtKB/Swiss-Prot
    P78396
    Related
    ENSP00000400666.1, ENST00000440264.5
    Conserved Domains (2) summary
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  3. NM_001111047.2 → NP_001104517.1  cyclin-A1

    See identical proteins and their annotated locations for NP_001104517.1

    Status: REVIEWED

    Source sequence(s)
    BC036346, DC395631
    Consensus CDS
    CCDS45031.1
    UniProtKB/Swiss-Prot
    P78396
    Conserved Domains (2) summary
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  4. NM_001413923.1 → NP_001400852.1  cyclin-A1

    Status: REVIEWED

    Source sequence(s)
    AL359767

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    36431517..36442870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535294.3 → XP_011533596.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_011533596.1

    UniProtKB/Swiss-Prot
    P78396
    Related
    ENSP00000486482.1, ENST00000630422.2
    Conserved Domains (2) summary
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  2. XM_011535295.3 → XP_011533597.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_011533597.1

    UniProtKB/Swiss-Prot
    P78396
    Conserved Domains (2) summary
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  3. XM_011535296.3 → XP_011533598.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_011533598.1

    UniProtKB/Swiss-Prot
    P78396
    Conserved Domains (2) summary
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    35651206..35662375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375156.1 → XP_054231131.1  cyclin-A1 isoform X1

  2. XM_054375155.1 → XP_054231130.1  cyclin-A1 isoform X1

  3. XM_054375154.1 → XP_054231129.1  cyclin-A1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003914.4: Suppressed sequence

    Description
    NM_003914.4: This RefSeq was removed because currently there is insufficient support for the translation start site.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P78396.1 GenPept UniProtKB/Swiss-Prot:P78396

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