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Ccna1 cyclin A1 [ Mus musculus (house mouse) ]

Gene ID: 12427, updated on 12-May-2024

Summary

Official Symbol
Ccna1provided by MGI
Official Full Name
cyclin A1provided by MGI
Primary source
MGI:MGI:108042
See related
Ensembl:ENSMUSG00000027793 AllianceGenome:MGI:108042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within several processes, including cell division; meiotic cell cycle; and spermatogenesis. Part of cyclin A1-CDK2 complex. Is expressed in several structures, including blastocyst; liver; testis; and tooth. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 38.8) and limb E14.5 (RPKM 0.7) See more
Orthologs
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Genomic context

See Ccna1 in Genome Data Viewer
Location:
3 C; 3 26.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54952890..54965055, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (55045469..55057634, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene serine rich and transmembrane domain containing 1 Neighboring gene predicted gene, 31358 Neighboring gene STARR-seq mESC enhancer starr_07690 Neighboring gene RIKEN cDNA 4931419H13 gene Neighboring gene STARR-seq mESC enhancer starr_07692 Neighboring gene STARR-seq mESC enhancer starr_07693 Neighboring gene STARR-seq mESC enhancer starr_07694 Neighboring gene spartin Neighboring gene coiled-coil domain containing 169

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC159139

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cyclin A1-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305221.2NP_001292150.1  cyclin-A1 isoform 1

    See identical proteins and their annotated locations for NP_001292150.1

    Status: VALIDATED

    Source sequence(s)
    AC127334
    Consensus CDS
    CCDS17356.1
    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Related
    ENSMUSP00000143447.2, ENSMUST00000198320.5
    Conserved Domains (3) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  2. NM_001428404.1NP_001415333.1  cyclin-A1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127334
    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
  3. NM_001428405.1NP_001415334.1  cyclin-A1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127334
  4. NM_001428406.1NP_001415335.1  cyclin-A1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127334
  5. NM_001428407.1NP_001415336.1  cyclin-A1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127334
  6. NM_007628.4NP_031654.2  cyclin-A1 isoform 1

    See identical proteins and their annotated locations for NP_031654.2

    Status: VALIDATED

    Source sequence(s)
    AC127334
    Consensus CDS
    CCDS17356.1
    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Related
    ENSMUSP00000029368.3, ENSMUST00000029368.7
    Conserved Domains (3) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

RNA

  1. NR_190341.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127334

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    54952890..54965055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252400.1XP_030108260.1  cyclin-A1 isoform X2

    Conserved Domains (3) summary
    pfam00134
    Location:170296
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:298360
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
  2. XM_030252402.1XP_030108262.1  cyclin-A1 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JEB5
    Related
    ENSMUSP00000142706.2, ENSMUST00000198102.5
    Conserved Domains (2) summary
    pfam00134
    Location:30132
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:134196
    Cyclin_C; Cyclin, C-terminal domain
  3. XM_006500951.4XP_006501014.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_006501014.1

    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Conserved Domains (3) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  4. XM_006500952.4XP_006501015.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_006501015.1

    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Related
    ENSMUSP00000142692.2, ENSMUST00000197238.5
    Conserved Domains (3) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  5. XM_036162875.1XP_036018768.1  cyclin-A1 isoform X4

    Conserved Domains (2) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cl40454
    Location:132270
    CYCLIN_SF; Cyclin box fold superfamily
  6. XM_036162876.1XP_036018769.1  cyclin-A1 isoform X4

    Conserved Domains (2) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cl40454
    Location:132270
    CYCLIN_SF; Cyclin box fold superfamily
  7. XM_006500954.5XP_006501017.1  cyclin-A1 isoform X3

    Conserved Domains (3) summary
    COG5024
    Location:134386
    COG5024; Cyclin [Cell division and chromosome partitioning]
    pfam00134
    Location:170272
    Cyclin_N; Cyclin, N-terminal domain
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
  8. XM_030252399.2XP_030108259.1  cyclin-A1 isoform X2

    Conserved Domains (3) summary
    pfam00134
    Location:170296
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:298360
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
  9. XM_006500950.5XP_006501013.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_006501013.1

    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Conserved Domains (3) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  10. XM_006500949.4XP_006501012.1  cyclin-A1 isoform X1

    Conserved Domains (3) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  11. XM_036162873.1XP_036018766.1  cyclin-A1 isoform X1

    UniProtKB/Swiss-Prot
    Q61456, Q8C5U1
    Conserved Domains (3) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
  12. XM_036162874.1XP_036018767.1  cyclin-A1 isoform X4

    Conserved Domains (2) summary
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N
    cl40454
    Location:132270
    CYCLIN_SF; Cyclin box fold superfamily
  13. XM_030252401.1XP_030108261.1  cyclin-A1 isoform X3

    Conserved Domains (3) summary
    COG5024
    Location:134386
    COG5024; Cyclin [Cell division and chromosome partitioning]
    pfam00134
    Location:170272
    Cyclin_N; Cyclin, N-terminal domain
    pfam16500
    Location:27101
    Cyclin_N2; N-terminal region of cyclin_N

RNA

  1. XR_003954275.2 RNA Sequence

  2. XR_004941269.1 RNA Sequence

  3. XR_004941268.1 RNA Sequence