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CCNA2 cyclin A2 [ Homo sapiens (human) ]

Gene ID: 890, updated on 8-Jul-2019

Summary

Official Symbol
CCNA2provided by HGNC
Official Full Name
cyclin A2provided by HGNC
Primary source
HGNC:HGNC:1578
See related
Ensembl:ENSG00000145386 MIM:123835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCN1; CCNA
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]
Expression
Broad expression in bone marrow (RPKM 15.5), lymph node (RPKM 14.7) and 20 other tissues See more
Orthologs

Genomic context

See CCNA2 in Genome Data Viewer
Location:
4q27
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (121816444..121823883, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122737599..122745153, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene annexin A5 Neighboring gene transmembrane protein 155 Neighboring gene uncharacterized LOC100192379 Neighboring gene exosome component 9 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene transient receptor potential cation channel subfamily C member 3 Neighboring gene uncharacterized LOC102724158

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to cyclin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
Ras protein signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
cell cycle G1/S phase transition IDA
Inferred from Direct Assay
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to cocaine IEA
Inferred from Electronic Annotation
more info
 
cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin-like growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to leptin stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to luteinizing hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to nitric oxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
histone phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to glucagon IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin A2-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
female pronucleus IEA
Inferred from Electronic Annotation
more info
 
male pronucleus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052974.1 RefSeqGene

    Range
    5001..12558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001237.5NP_001228.2  cyclin-A2

    Status: REVIEWED

    Source sequence(s)
    AC079341
    Consensus CDS
    CCDS3723.1
    Related
    ENSP00000274026.5, ENST00000274026.10
    Conserved Domains (3) summary
    pfam00134
    Location:181307
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:309427
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:28166
    Cyclin_N2; N-terminal region of cyclin_N

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    121816444..121823883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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