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CCNA2 cyclin A2 [ Homo sapiens (human) ]

Gene ID: 890, updated on 17-Oct-2021

Summary

Official Symbol
CCNA2provided by HGNC
Official Full Name
cyclin A2provided by HGNC
Primary source
HGNC:HGNC:1578
See related
Ensembl:ENSG00000145386 MIM:123835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCN1; CCNA
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]
Expression
Broad expression in bone marrow (RPKM 15.5), lymph node (RPKM 14.7) and 20 other tissues See more
Orthologs
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Genomic context

See CCNA2 in Genome Data Viewer
Location:
4q27
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (121816444..121823883, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122737599..122745038, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 43 Neighboring gene uncharacterized LOC100192379 Neighboring gene Sharpr-MPRA regulatory region 4891 Neighboring gene exosome component 9 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene transient receptor potential cation channel subfamily C member 3 Neighboring gene uncharacterized LOC102724158

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Ras protein signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle G1/S phase transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cocaine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin-like growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to leptin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to luteinizing hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nitric oxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cochlea development IEA
Inferred from Electronic Annotation
more info
 
involved_in histone phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to glucagon IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin A2-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in female pronucleus IEA
Inferred from Electronic Annotation
more info
 
located_in male pronucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052974.1 RefSeqGene

    Range
    5001..12558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001237.5NP_001228.2  cyclin-A2

    Status: REVIEWED

    Source sequence(s)
    AC079341
    Consensus CDS
    CCDS3723.1
    Related
    ENSP00000274026.5, ENST00000274026.10
    Conserved Domains (3) summary
    pfam16500
    Location:28166
    Cyclin_N2; N-terminal region of cyclin_N
    cd20561
    Location:175305
    CYCLIN_CCNA2_rpt1; first cyclin box found in cyclin-A2 (CCNA2) and similar proteins
    cd20564
    Location:309419
    CYCLIN_CCNA2_rpt2; second cyclin box found in cyclin-A2 (CCNA2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    121816444..121823883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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