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Ccna2 cyclin A2 [ Mus musculus (house mouse) ]

Gene ID: 12428, updated on 17-Jan-2023

Summary

Official Symbol
Ccna2provided by MGI
Official Full Name
cyclin A2provided by MGI
Primary source
MGI:MGI:108069
See related
Ensembl:ENSMUSG00000027715 AllianceGenome:MGI:108069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccn1; Ccna; Cyca; Ccn-1; CycA2
Summary
Enables protein kinase binding activity. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in cytoplasm; female pronucleus; and male pronucleus. Part of cyclin A2-CDK2 complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 91.0), liver E14.5 (RPKM 83.6) and 15 other tissues See more
Orthologs
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Genomic context

See Ccna2 in Genome Data Viewer
Location:
3 B; 3 17.67 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (36619014..36627187, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (36564865..36573038, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 43 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene exosome component 9 Neighboring gene Bardet-Biedl syndrome 7 (human) Neighboring gene transient receptor potential cation channel, subfamily C, member 3 Neighboring gene predicted gene, 35856

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin A2-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin A2-CDK2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in female pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in male pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cyclin-A2
Names
Cyclin A2 (Cyclin A)
cyclin-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009828.3NP_033958.2  cyclin-A2

    See identical proteins and their annotated locations for NP_033958.2

    Status: VALIDATED

    Source sequence(s)
    AC117584, AK044924, BC052730
    Consensus CDS
    CCDS17313.1
    UniProtKB/Swiss-Prot
    P51943, Q8BRG1
    Related
    ENSMUSP00000029270.4, ENSMUST00000029270.10
    Conserved Domains (3) summary
    pfam00134
    Location:171297
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:299417
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:22152
    Cyclin_N2; N-terminal region of cyclin_N

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    36619014..36627187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)