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CDC16 cell division cycle 16 [ Homo sapiens (human) ]

Gene ID: 8881, updated on 3-Jun-2018
Official Symbol
CDC16provided by HGNC
Official Full Name
cell division cycle 16provided by HGNC
Primary source
HGNC:HGNC:1720
See related
Ensembl:ENSG00000130177 MIM:603461; Vega:OTTHUMG00000017402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC6; CUT9; ANAPC6; CDC16Hs
Summary
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 21.1) and 25 other tissues See more
Orthologs
See CDC16 in Genome Data Viewer
Location:
13q34
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (114234845..114272723)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (115000320..115038150)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RAS p21 protein activator 3 Neighboring gene uncharacterized LOC107987192 Neighboring gene uncharacterized LOC107984593 Neighboring gene CFAP97 domain containing 2 Neighboring gene uncharacterized LOC105370384 Neighboring gene microRNA 548ar Neighboring gene microRNA 4502 Neighboring gene UPF3A, regulator of nonsense mediated mRNA decay

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of cell division cycle 16 homolog (S. cerevisiae) (CDC16) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

  • APC-Cdc20 mediated degradation of Nek2A, organism-specific biosystem (from REACTOME)
    APC-Cdc20 mediated degradation of Nek2A, organism-specific biosystemLike Cyclin A, NIMA-related kinase 2A (Nek2A) is degraded during pro-metaphase in a checkpoint-independent manner.
  • APC/C complex, organism-specific biosystem (from KEGG)
    APC/C complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
  • APC/C complex, conserved biosystem (from KEGG)
    APC/C complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
  • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
    APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
  • APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem (from REACTOME)
    APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystemThe degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister...
  • APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
    APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemThe separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohe...
  • APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
    APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemFollowing phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the ...
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
  • APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, organism-specific biosystem (from REACTOME)
    APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, organism-specific biosystemAPC:CDC20 mediates the degradation of a number of cell cycle proteins including Cyclin A and Nek2A.
  • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemAPC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein ...
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystem (from REACTOME)
    Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystemCdh1 is degraded by the APC/C during in G1 and G0. This auto-regulation may contribute to reducing the levels of Cdh1 levels during G1 and G0 (Listovsky et al., 2004).
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A, organism-specific biosystem (from REACTOME)
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A, organism-specific biosystemCyclin A, functions in mitosis as well as DNA replication and is degraded in the interim by the APC/C to permit normal chromosome segregation, cell division, and the onset of S phase (see Lukas an...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
    Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystem (from REACTOME)
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystemThe activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystem (from REACTOME)
    Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystemIn the direct inhibition model, the cytosolic Mitotic Checkpoint Complex, consisting of hBUBR1, hBUB3, Cdc20 and Mad2, directly inhibits APC/C by binding to it.
  • Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystem (from REACTOME)
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystemThe target of the mitotic checkpoint is the Anaphase Promoting Complex/Cyclosome (APC/C) an E3 ubiquitin ligase that targets proteins whose destruction is essential for mitotic exit. Currently, there...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Spindle Checkpoint, organism-specific biosystem (from REACTOME)
    Mitotic Spindle Checkpoint, organism-specific biosystemThe mitotic checkpoint or spindle assembly checkpoint is an evolutionarily conserved mechanism that ensures that cells with misaligned chromosomes do not exit mitosis and divide to form aneuploid cel...
  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Phosphorylation of the APC/C, organism-specific biosystem (from REACTOME)
    Phosphorylation of the APC/C, organism-specific biosystemPhosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation...
  • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
    Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
  • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
    Regulation of mitotic cell cycle, organism-specific biosystem
    Regulation of mitotic cell cycle
  • Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystem (from REACTOME)
    Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystemThe culture medium of senescent cells in enriched in secreted proteins when compared with the culture medium of quiescent i.e. presenescent cells and these secreted proteins constitute the so-called ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
spindle TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cell division cycle protein 16 homolog
Names
anaphase-promoting complex, subunit 6
cell division cycle 16 homolog
cyclosome subunit 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078645.2NP_001072113.1  cell division cycle protein 16 homolog isoform 1

    See identical proteins and their annotated locations for NP_001072113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1 and 2 encode the same isoform (1) .
    Source sequence(s)
    AW662777, AW953481, BM663581, BQ051608, BQ424567, DC391369
    Consensus CDS
    CCDS9542.2
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    A0A024RDZ2
    Related
    ENSP00000348554.3, OTTHUMP00000178881, ENST00000356221.7, OTTHUMT00000276737
    Conserved Domains (5) summary
    sd00006
    Location:402430
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:447511
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:371511
    TPR_11; TPR repeat
    cl26860
    Location:337402
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  2. NM_001318517.2NP_001305446.1  cell division cycle protein 16 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice acceptor site in the 5' coding region and lacks an exon segment in the 3' UTR, compared to variant 2. Variants 3 and 5 encode the same isoform (2), which is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK315302, BM663581, DC391369, U18291
    Consensus CDS
    CCDS81786.1
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    B2RCW0
    Related
    ENSP00000252457.5, OTTHUMP00000018786, ENST00000252457.9, OTTHUMT00000045965
    Conserved Domains (5) summary
    sd00006
    Location:401429
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1593
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:446510
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:370510
    TPR_11; TPR repeat
    cl26860
    Location:336401
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  3. NM_001318518.2NP_001305447.1  cell division cycle protein 16 homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice acceptor site in the 5' coding region and lacks an in-frame exon in the 3' coding region, compared to variant 2. These differences result in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AF164598, AK315302, BC050575, BM663581, DC391369
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    B2RCW0
    Related
    ENSP00000252458.6, OTTHUMP00000018782, ENST00000252458.6, OTTHUMT00000045960
    Conserved Domains (5) summary
    smart00028
    Location:396426
    TPR; Tetratricopeptide repeats
    sd00006
    Location:395421
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1593
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:395457
    TPR_11; TPR repeat
    pfam13424
    Location:349420
    TPR_12; Tetratricopeptide repeat
  4. NM_001330101.1NP_001317030.1  cell division cycle protein 16 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice acceptor site in the 5' coding region, compared to variant 2. Variants 3 and 5 encode the same isoform (2), which is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK315302, BC050575, BM663581, DC391369, U18291
    Consensus CDS
    CCDS81786.1
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    B2RCW0
    Conserved Domains (5) summary
    sd00006
    Location:401429
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1593
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:446510
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:370510
    TPR_11; TPR repeat
    cl26860
    Location:336401
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  5. NM_001330104.1NP_001317033.1  cell division cycle protein 16 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 6 and 7 encode the same isoform (4).
    Source sequence(s)
    BC050575, BM663581, BQ668939, BQ944893, CN401097, DC391369
    Consensus CDS
    CCDS81787.1
    UniProtKB/Swiss-Prot
    Q13042
    Conserved Domains (4) summary
    sd00006
    Location:308336
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:353417
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:277417
    TPR_11; TPR repeat
    cl26860
    Location:243308
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  6. NM_001330105.1NP_001317034.1  cell division cycle protein 16 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks a 5' exon and lacks an exon segment in the 3' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 6 and 7 encode the same isoform (4).
    Source sequence(s)
    BM663581, BQ009960, BQ668939, BQ944893, CN401097, DC391369
    Consensus CDS
    CCDS81787.1
    UniProtKB/Swiss-Prot
    Q13042
    Related
    ENSP00000364457.1, ENST00000375308.5
    Conserved Domains (4) summary
    sd00006
    Location:308336
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:353417
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:277417
    TPR_11; TPR repeat
    cl26860
    Location:243308
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  7. NM_003903.4NP_003894.3  cell division cycle protein 16 homolog isoform 1

    See identical proteins and their annotated locations for NP_003894.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon segment in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BM663581, BQ051608, BQ424567, BU687000, DC391369
    Consensus CDS
    CCDS9542.2
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    A0A024RDZ2
    Related
    ENSP00000353549.3, ENST00000360383.7
    Conserved Domains (5) summary
    sd00006
    Location:402430
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:447511
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:371511
    TPR_11; TPR repeat
    cl26860
    Location:337402
    PRK15359; type III secretion system chaperone protein SscB; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    114234845..114272723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534853.2XP_011533155.1  cell division cycle protein 16 homolog isoform X2

    Conserved Domains (4) summary
    smart00028
    Location:448478
    TPR; Tetratricopeptide repeats
    sd00006
    Location:447473
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:447509
    TPR_11; TPR repeat
  2. XM_017020831.2XP_016876320.1  cell division cycle protein 16 homolog isoform X3

    Conserved Domains (4) summary
    smart00028
    Location:448478
    TPR; Tetratricopeptide repeats
    sd00006
    Location:447473
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:447509
    TPR_11; TPR repeat
  3. XM_005266206.2XP_005266263.1  cell division cycle protein 16 homolog isoform X5

    Conserved Domains (5) summary
    smart00028
    Location:448478
    TPR; Tetratricopeptide repeats
    sd00006
    Location:402430
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:401476
    TPR_11; TPR repeat
    pfam13424
    Location:447509
    TPR_12; Tetratricopeptide repeat
  4. XM_011534851.2XP_011533153.1  cell division cycle protein 16 homolog isoform X1

    See identical proteins and their annotated locations for XP_011533153.1

    Conserved Domains (5) summary
    smart00028
    Location:397427
    TPR; Tetratricopeptide repeats
    sd00006
    Location:396422
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:396458
    TPR_11; TPR repeat
    pfam13424
    Location:350421
    TPR_12; Tetratricopeptide repeat
  5. XM_017020830.2XP_016876319.1  cell division cycle protein 16 homolog isoform X1

    Related
    ENSP00000486027.1, ENST00000628084.2
    Conserved Domains (5) summary
    smart00028
    Location:397427
    TPR; Tetratricopeptide repeats
    sd00006
    Location:396422
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:396458
    TPR_11; TPR repeat
    pfam13424
    Location:350421
    TPR_12; Tetratricopeptide repeat
  6. XM_017020833.1XP_016876322.1  cell division cycle protein 16 homolog isoform X4

    UniProtKB/Swiss-Prot
    Q13042
    Conserved Domains (4) summary
    sd00006
    Location:308336
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:353417
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:277417
    TPR_11; TPR repeat
    cl26860
    Location:243308
    PRK15359; type III secretion system chaperone protein SscB; Provisional

RNA

  1. XR_001749718.1 RNA Sequence

  2. XR_001749719.1 RNA Sequence

  3. XR_001749713.2 RNA Sequence

  4. XR_001749714.2 RNA Sequence

  5. XR_245358.2 RNA Sequence

  6. XR_001749716.2 RNA Sequence

  7. XR_245359.4 RNA Sequence

  8. XR_001749715.2 RNA Sequence

  9. XR_001749717.2 RNA Sequence

  10. XR_245360.2 RNA Sequence

  11. XR_941424.3 RNA Sequence

  12. XR_001749720.1 RNA Sequence

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