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CDC16 cell division cycle 16 [ Homo sapiens (human) ]

Gene ID: 8881, updated on 7-Jun-2020

Summary

Official Symbol
CDC16provided by HGNC
Official Full Name
cell division cycle 16provided by HGNC
Primary source
HGNC:HGNC:1720
See related
Ensembl:ENSG00000130177 MIM:603461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC6; CUT9; ANAPC6; CDC16Hs
Summary
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 21.1) and 25 other tissues See more
Orthologs

Genomic context

See CDC16 in Genome Data Viewer
Location:
13q34
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (114234845..114272723)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (115000320..115038150)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RAS p21 protein activator 3 Neighboring gene uncharacterized LOC107987192 Neighboring gene uncharacterized LOC107984593 Neighboring gene CFAP97 domain containing 2 Neighboring gene uncharacterized LOC105370384 Neighboring gene microRNA 548ar Neighboring gene microRNA 4502 Neighboring gene UPF3A regulator of nonsense mediated mRNA decay

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cell division cycle 16 homolog (S. cerevisiae) (CDC16) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell division cycle protein 16 homolog
Names
anaphase-promoting complex, subunit 6
cell division cycle 16 homolog
cyclosome subunit 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078645.3NP_001072113.1  cell division cycle protein 16 homolog isoform 1

    See identical proteins and their annotated locations for NP_001072113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1 and 2 encode the same isoform (1) .
    Source sequence(s)
    AW662777, AW953481, BM663581, BQ051608, BQ424567, DC391369
    Consensus CDS
    CCDS9542.2
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    A0A024RDZ2
    Related
    ENSP00000348554.3, ENST00000356221.8
    Conserved Domains (5) summary
    sd00006
    Location:402430
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:447511
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:371511
    TPR_11; TPR repeat
    cl26860
    Location:337402
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  2. NM_001318517.2NP_001305446.1  cell division cycle protein 16 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice acceptor site in the 5' coding region and lacks an exon segment in the 3' UTR, compared to variant 2. Variants 3 and 5 encode the same isoform (2), which is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK315302, BM663581, DC391369, U18291
    Consensus CDS
    CCDS81786.1
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    B2RCW0
    Related
    ENSP00000252457.5, ENST00000252457.9
    Conserved Domains (5) summary
    sd00006
    Location:401429
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1593
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:446510
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:370510
    TPR_11; TPR repeat
    cl26860
    Location:336401
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  3. NM_001318518.3NP_001305447.1  cell division cycle protein 16 homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice acceptor site in the 5' coding region and lacks an in-frame exon in the 3' coding region, compared to variant 2. These differences result in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AF164598, AK315302, BC050575, BM663581, DC391369
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    B2RCW0
    Related
    ENSP00000252458.6, ENST00000252458.6
    Conserved Domains (5) summary
    smart00028
    Location:396426
    TPR; Tetratricopeptide repeats
    sd00006
    Location:395421
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1593
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:395457
    TPR_11; TPR repeat
    pfam13424
    Location:349420
    TPR_12; Tetratricopeptide repeat
  4. NM_001330101.2NP_001317030.1  cell division cycle protein 16 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice acceptor site in the 5' coding region, compared to variant 2. Variants 3 and 5 encode the same isoform (2), which is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK315302, BC050575, BM663581, DC391369, U18291
    Consensus CDS
    CCDS81786.1
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    B2RCW0
    Conserved Domains (5) summary
    sd00006
    Location:401429
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1593
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:446510
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:370510
    TPR_11; TPR repeat
    cl26860
    Location:336401
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  5. NM_001330104.2NP_001317033.1  cell division cycle protein 16 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 6 and 7 encode the same isoform (4).
    Source sequence(s)
    BC050575, BM663581, BQ668939, BQ944893, CN401097, DC391369
    Consensus CDS
    CCDS81787.1
    UniProtKB/Swiss-Prot
    Q13042
    Conserved Domains (4) summary
    sd00006
    Location:308336
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:353417
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:277417
    TPR_11; TPR repeat
    cl26860
    Location:243308
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  6. NM_001330105.1NP_001317034.1  cell division cycle protein 16 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks a 5' exon and lacks an exon segment in the 3' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 6 and 7 encode the same isoform (4).
    Source sequence(s)
    BM663581, BQ009960, BQ668939, BQ944893, CN401097, DC391369
    Consensus CDS
    CCDS81787.1
    UniProtKB/Swiss-Prot
    Q13042
    Related
    ENSP00000364457.1, ENST00000375308.5
    Conserved Domains (4) summary
    sd00006
    Location:308336
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:353417
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:277417
    TPR_11; TPR repeat
    cl26860
    Location:243308
    PRK15359; type III secretion system chaperone protein SscB; Provisional
  7. NM_003903.4NP_003894.3  cell division cycle protein 16 homolog isoform 1

    See identical proteins and their annotated locations for NP_003894.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon segment in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BM663581, BQ051608, BQ424567, BU687000, DC391369
    Consensus CDS
    CCDS9542.2
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    A0A024RDZ2
    Related
    ENSP00000353549.3, ENST00000360383.7
    Conserved Domains (5) summary
    sd00006
    Location:402430
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:447511
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:371511
    TPR_11; TPR repeat
    cl26860
    Location:337402
    PRK15359; type III secretion system chaperone protein SscB; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    114234845..114272723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534853.2XP_011533155.1  cell division cycle protein 16 homolog isoform X2

    Related
    ENSP00000497168.1, ENST00000650489.1
    Conserved Domains (4) summary
    smart00028
    Location:448478
    TPR; Tetratricopeptide repeats
    sd00006
    Location:447473
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:447509
    TPR_11; TPR repeat
  2. XM_017020831.2XP_016876320.1  cell division cycle protein 16 homolog isoform X3

    Conserved Domains (4) summary
    smart00028
    Location:448478
    TPR; Tetratricopeptide repeats
    sd00006
    Location:447473
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:447509
    TPR_11; TPR repeat
  3. XM_005266206.2XP_005266263.1  cell division cycle protein 16 homolog isoform X5

    Conserved Domains (5) summary
    smart00028
    Location:448478
    TPR; Tetratricopeptide repeats
    sd00006
    Location:402430
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:401476
    TPR_11; TPR repeat
    pfam13424
    Location:447509
    TPR_12; Tetratricopeptide repeat
  4. XM_011534851.2XP_011533153.1  cell division cycle protein 16 homolog isoform X1

    See identical proteins and their annotated locations for XP_011533153.1

    Conserved Domains (5) summary
    smart00028
    Location:397427
    TPR; Tetratricopeptide repeats
    sd00006
    Location:396422
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:396458
    TPR_11; TPR repeat
    pfam13424
    Location:350421
    TPR_12; Tetratricopeptide repeat
  5. XM_017020830.2XP_016876319.1  cell division cycle protein 16 homolog isoform X1

    Related
    ENSP00000486027.1, ENST00000628084.2
    Conserved Domains (5) summary
    smart00028
    Location:397427
    TPR; Tetratricopeptide repeats
    sd00006
    Location:396422
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1594
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:396458
    TPR_11; TPR repeat
    pfam13424
    Location:350421
    TPR_12; Tetratricopeptide repeat
  6. XM_017020833.1XP_016876322.1  cell division cycle protein 16 homolog isoform X4

    UniProtKB/Swiss-Prot
    Q13042
    Conserved Domains (4) summary
    sd00006
    Location:308336
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:353417
    TPR_12; Tetratricopeptide repeat
    cl26002
    Location:277417
    TPR_11; TPR repeat
    cl26860
    Location:243308
    PRK15359; type III secretion system chaperone protein SscB; Provisional

RNA

  1. XR_001749718.1 RNA Sequence

  2. XR_001749719.1 RNA Sequence

  3. XR_001749713.2 RNA Sequence

  4. XR_001749714.2 RNA Sequence

  5. XR_245358.2 RNA Sequence

  6. XR_001749716.2 RNA Sequence

  7. XR_245359.4 RNA Sequence

  8. XR_001749715.2 RNA Sequence

  9. XR_001749717.2 RNA Sequence

  10. XR_245360.2 RNA Sequence

  11. XR_941424.3 RNA Sequence

  12. XR_001749720.1 RNA Sequence

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