Conserved Protein Domain Family
ANAPC3

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pfam12895: ANAPC3 
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Anaphase-promoting complex, cyclosome, subunit 3
Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.
Statistics
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PSSM-Id: 289650
View PSSM: pfam12895
Aligned: 109 rows
Threshold Bit Score: 36.8545
Threshold Setting Gi: 74691126
Created: 23-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam12895 is classified as a model that may span more than one domain.
pfam12895 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XPI_A         96 MQQQYKCAAFVGEKVL---DITGNPNDAFWL--AQVYCCTGDYARAKCLLTKEdl-yNRSS--ACRYLAAFCLV-KL-YD 165
gi 81821658    87 EQGNTKEAINYFEKVVkesPIPESLEKSTLYslAQLALSDGQFQRAISFLDQWeglaEEGEmgKAWVLKAQAYY-QA-DK 164
gi 124462788   44 WLDNYKDAILWADKALs--INSKHINSLFTK--GESLRMLGEYEDAIKILDVAlnqnPNHD--QSLVCKGACLQ-SL-QK 115
gi 124470545  127 GLGQYDEAIIWADKALq--VDQKHCSSLYIK--GNSLRLLKKYKEAMKVIEQSlkinPNHF--DSLKIKGACLH-DQ-SQ 198
gi 124450761   69 MLGQYNEAIIWADKALq--VNPQHCYSLFTK--GNSLRQLKKFKEAMEVIEQSlkinPNHF--DSLRIKGECLH-DQ-KQ 140
gi 74881602   179 MYIYENNKMFLTDATL-----KTSLYRQLI---IRLFFSLKDFTKCIKIIDETke-yNNNL--DILYIYAESLY-KL-KD 245
gi 495546384   32 DLFEYSNAEKHLLKIIe--V-ADTNKNKYLL--ARCYFEQEKYNLTEVIIEEVia-nQETT--DYLELYCECLL-KL-NQ 101
gi 502878820   14 LEENYEEAIKLCDEAIe--KDDKDEDAYFNM--AFAKINLQRYKEAIEGYSKVielnNKN---EIAYINRSVCY-EInKQ 85
gi 489854750  185 ASGAFEEALPYYEKAT---AENESMDTLFGY--GLTAYQAKEYTQAIHALEHLke-hDPAY--TTLYTYLAKSYqEN-NK 255
gi 503070106  256 NLKQYANAIPYLEAYKg-kRGKWSNTDYYLL--GYCFYKQGDFVNAIQQFNKIiggtNSVSq-NAYYHLAECYL-KL-DK 329
                          90
                  ....*....|.
2XPI_A        166 WQGALNLLGET 176
gi 81821658   165 YQEALSLIDKA 175
gi 124462788  116 YQEAINCYNQA 126
gi 124470545  199 YKEALIFMKKL 209
gi 124450761  141 YQQALIFYDKA 151
gi 74881602   246 YKKSITYLKEY 256
gi 495546384  102 KDQALEVYKRI 112
gi 502878820   86 YKEAISDLDNV 96
gi 489854750  256 PEQALEVLKEG 266
gi 503070106  330 KQEALNAFRNA 340
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