KAT2B lysine acetyltransferase 2B [Homo sapiens (human)] - Gene

Summary

Official Symbol: KAT2Bprovided by HGNC
Official Full Name: lysine acetyltransferase 2Bprovided by HGNC
Primary source: HGNC:HGNC:8638
See related: Ensembl:ENSG00000114166 MIM:602303
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAF; PCAF; P/CAF
Summary: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 17.7), bone marrow (RPKM 16.3) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 3p24.3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	3	NC_000003.12 (20040032..20154404)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (20081524..20195896)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Thus, this study warrants that F2209-0381 could become a novel, potent and cell permeable drug of PCAF thereby it could combat its mediated diseases.
Title: Structure based identification and biological evaluation of novel and potent inhibitors of PCAF catalytic domain.
KAT2A/2B acetylation of PLK4 prevents centrosome amplification
Title: KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
The effects of acetylated Lin28B on let-7a-1 and let-7g are similar to that of stable knockdown of Lin28B in H1299 cells. The new role of PCAF in mediating Lin28B acetylation and the specific release of its target microRNAs in H1299 cells may shed light on the potential application of let-7 in the clinical treatment of lung cancer patients
Title: PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells.
Data indicate lysine acetyltransferase 2B (KAT2B) as a susceptibility gene for kidney and heart disease in adducin 3 (gamma) protein (ADD3)-associated disorders.
Title: A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies.
PCAF/GCN5-mediated lysine 163 acetylation of RPA1 is crucial for nucleotide excision repair.
Title: PCAF/GCN5-Mediated Acetylation of RPA1 Promotes Nucleotide Excision Repair.
PCAF and ADA3 transcriptionally regulate PACS1 and PACS1 is a key regulator of BAX/BAK oligomerization and the intrinsic (mitochondrial) pathway to apoptosis.
Title: Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.
Knockdown of the acetyltransferase Kat2b erases H3K9ac signals, disrupts Sox2 binding, and fails the differentiation during human neuroectodermal commitment.
Title: Nucleosome eviction along with H3K9ac deposition enhances Sox2 binding during human neuroectodermal commitment.
GCN5 upregulation is especially common in UCCs. GCN5 knockdown impeded growth of specific UCCs, whereas PCAF knockdown elicited minor effects.
Title: Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells.
histone H3K9 acetyltransferase PCAF plays a critical role in osteogenic differentiation of mesenchymal stem cells.
Title: Histone H3K9 Acetyltransferase PCAF Is Essential for Osteogenic Differentiation Through Bone Morphogenetic Protein Signaling and May Be Involved in Osteoporosis.
cancer associated fibroblasts (CAFs) promoted hepatocellular cancer (HCC) growth via IL-6/STAT3/AKT pathway and TIMP-1 over-expression driven by IL-6/STAT3 pathway in HCC cells brought in more CAFs through activating liver fibroblasts.
Title: IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment.

Submit: New GeneRIF Correction See all GeneRIFs (138)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Acetylation of HIV-1 Tat by P/CAF at Lys28 and binding of P/CAF to Lys50 acetylated Tat regulates Tat binding to cyclin T1 and HIV-1 TAR RNA, as well as Tat-mediated transactivation of the HIV-1 LTR promoter, by allowing Tat to dissociate from TAR RNA	PubMed
	tat	Acetylation of HIV-1 Tat by P/CAF at Lysine 28 enhances Tat binding to CDK9, indicating P/CAF may regulate Tat-mediated transactivation of the HIV-1 LTR	PubMed
	tat	HIV-1 Tat is acetylated by P/CAF on Lysine 28	PubMed
	tat	Small-molecule inhibitors inbihit PCAF bromodomain/Tat-AcK50 protein-peptide interaction, potentially leads for the anti-HIV/AIDS therapeutic strategy	PubMed
	tat	The K19A, K29R, and K41A mutations decrease HIV-1 Tat binding to PCAF, whereas the K12Q and K12R mutations increase the binding	PubMed
	tat	HIV-1 Tat recruits P/CAF, as well as other known cellular acetyltransferases, to the HIV-1 LTR promoter, an effect involved in the acetylation of histones H3 and H4, and HIV-1 transcriptional activation	PubMed
	tat	HIV-1 Tat interaction with P/CAF and other histone acetyl transferases is preferentially important for Tat-mediated transactivation of integrated, but not unintegrated, HIV-1 LTR promoter	PubMed
	tat	HIV-1 Tat forms a ternary complex with p300 and P/CAF	PubMed
	tat	HIV-1 Tat synergizes with P/CAF to activate the HIV-1 LTR promoter	PubMed
	tat	Association of tumor protein p73 with HIV-1 Tat prevents the acetylation of Tat on lysine 28 by PCAF	PubMed
	tat	Binding of HIV-1 Tat to P/CAF inhibits acetylation of p53 on Lysine320 leading to repression of p53-mediated promoter transactivation, suggesting a mechanism whereby Tat may impair tumor suppressor functions and favor neoplasia establishment during AIDS	PubMed
	tat	The bromodomain (amino acids 712-832) of P/CAF mediates its binding to amino acids 20-40 of non-acetylated HIV-1 Tat, to amino acids 48-57 in the arginine rich motif of Lys50 acetylated Tat, while Lys28 acetylation of Tat abrogates P/CAF binding to Tat	PubMed
	tat	HIV-1 Tat inhibits the transcriptional activation activity of P/CAF	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
B-WICH complex positively regulates rRNA expression, organism-specific biosystem (from REACTOME)
B-WICH complex positively regulates rRNA expression, organism-specific biosystemThe B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c) (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001,...
Cardiac conduction, organism-specific biosystem (from REACTOME)
Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
Chromatin organization, organism-specific biosystem (from REACTOME)
Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemWhen found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutatio...
Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemAs NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signal...
Deubiquitination, organism-specific biosystem (from REACTOME)
Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
Diseases of signal transduction, organism-specific biosystem (from REACTOME)
Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
E2F transcription factor network, organism-specific biosystem
E2F transcription factor network
Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
FoxO family signaling, organism-specific biosystem
FoxO family signaling
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
HATs acetylate histones, organism-specific biosystem (from REACTOME)
HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Metalloprotease DUBs, organism-specific biosystem (from REACTOME)
Metalloprotease DUBs, organism-specific biosystemThe JAB1/MPN +/MOV34 (JAMM) domain metalloproteases cleave the isopeptide bond at or near the the attachment point of polyubiquitin and substrate. PSMD14 (RPN11), STAMBP (AMSH), STAMBPL1 (AMSH-LP), a...
Muscle contraction, organism-specific biosystem (from REACTOME)
Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Notch signaling pathway, organism-specific biosystem (from KEGG)
Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Notch signaling pathway, conserved biosystem (from KEGG)
Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Notch-HLH transcription pathway, organism-specific biosystem (from REACTOME)
Notch-HLH transcription pathway, organism-specific biosystemTHE NOTCH-HLH TRANSCRIPTION PATHWAY: Notch signaling was first identified in Drosophila, where it has been studied in detail at the genetic, molecular, biochemical and cellular levels (reviewed in ...
Physiological factors, organism-specific biosystem (from REACTOME)
Physiological factors, organism-specific biosystemCardiovascular homeostasis can be regulated by natriuretic peptides (Pandey 2014).
Positive epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
Positive epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2...
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
Pre-NOTCH Expression and Processing, organism-specific biosystem (from REACTOME)
Pre-NOTCH Expression and Processing, organism-specific biosystemIn humans and other mammals the NOTCH gene family has four members, NOTCH1, NOTCH2, NOTCH3 and NOTCH4, encoded on four different chromosomes. Their transcription is developmentally regulated and tiss...
Pre-NOTCH Transcription and Translation, organism-specific biosystem (from REACTOME)
Pre-NOTCH Transcription and Translation, organism-specific biosystemIn humans, the NOTCH protein family has four members: NOTCH1, NOTCH2, NOTCH3 and NOTCH4. NOTCH1 protein was identified first, as the product of a chromosome 9 gene translocated in T-cell acute lympho...
RNA Polymerase I Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase I Promoter Clearance, organism-specific biosystemPromoter clearance is one of the rate-limiting steps in Polymerase I transcription. This step is composed of three phases, promoter opening, transcription initiation and promoter escape.
RNA Polymerase I Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase I Transcription, organism-specific biosystemThe rRNA genes are transcribed by RNA polymerase I, one of three eukaryotic nuclear RNA polymerases. The polymerase is a multisubunit complex, composed of two large subunits (the most conserved porti...
RNA Polymerase I Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase I Transcription Initiation, organism-specific biosystemDuring initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymeras...
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystemTranscription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters.
Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
Regulation of Androgen receptor activity, organism-specific biosystem
Regulation of Androgen receptor activity
Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
Regulation of nuclear SMAD2/3 signaling
Retinoic acid receptors-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
Retinoic acid receptors-mediated signaling, organism-specific biosystem
Retinoic acid receptors-mediated signaling
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by NOTCH, organism-specific biosystem (from REACTOME)
Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemMutations in the heterodimerization domain (HD) and PEST domain of NOTCH1 are frequently found in cis in T-cell acute lymphoblastic leukemia. While HD mutations alone result in up to ~10-fold increas...
Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemNOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prol...
Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1 in Cancer, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). This tra...
Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by HDAC Class I, organism-specific biosystem
Signaling events mediated by HDAC Class I
Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by HDAC Class III, organism-specific biosystem
Signaling events mediated by HDAC Class III
Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...
p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
p53 pathway, organism-specific biosystem
p53 pathway

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-84592 (e-PCR)
- UniSTS:102920

SHGC-111194 (e-PCR)
- UniSTS:168209

RH48918 (e-PCR)
- UniSTS:27671

SHGC-82800 (e-PCR)
- UniSTS:102433

RH91328 (e-PCR)
- UniSTS:88956

SHGC-76766 (e-PCR)
- UniSTS:47566

Homology

Homologs of the KAT2B gene: The KAT2B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 221 organisms have orthologs with human gene KAT2B
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
RNA polymerase II regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
cyclin-dependent protein serine/threonine kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
diamine N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
histone acetyltransferase activity	EXP Inferred from Experiment more info	PubMed
histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
histone acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	IDA Inferred from Direct Assay more info	PubMed
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISS Inferred from Sequence or Structural Similarity more info
peptide-lysine-N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
transcription coregulator activity	IPI Inferred from Physical Interaction more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
N-terminal peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
Notch signaling pathway	TAS Traceable Author Statement more info
cell cycle arrest	TAS Traceable Author Statement more info	PubMed
cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
heart development	ISS Inferred from Sequence or Structural Similarity more info
histone H3 acetylation	IDA Inferred from Direct Assay more info	PubMed
histone H3-K9 acetylation	IEA Inferred from Electronic Annotation more info
internal peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
limb development	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of centriole replication	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Notch signaling pathway	TAS Traceable Author Statement more info
positive regulation of gene expression, epigenetic	TAS Traceable Author Statement more info
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription of Notch receptor target	TAS Traceable Author Statement more info
protein acetylation	IDA Inferred from Direct Assay more info	PubMed
regulation of megakaryocyte differentiation	TAS Traceable Author Statement more info
regulation of protein ADP-ribosylation	IDA Inferred from Direct Assay more info	PubMed
rhythmic process	IEA Inferred from Electronic Annotation more info
transcription initiation from RNA polymerase II promoter	TAS Traceable Author Statement more info
viral process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
A band	IEA Inferred from Electronic Annotation more info
Ada2/Gcn5/Ada3 transcription activator complex	IDA Inferred from Direct Assay more info	PubMed
I band	IEA Inferred from Electronic Annotation more info
PCAF complex	NAS Non-traceable Author Statement more info	PubMed
actomyosin	IEA Inferred from Electronic Annotation more info
centrosome	IDA Inferred from Direct Assay more info	PubMed
kinetochore	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISS Inferred from Sequence or Structural Similarity more info
protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: histone acetyltransferase KAT2B

Names: CREBBP-associated factor; K(lysine) acetyltransferase 2B; histone acetylase PCAF; histone acetyltransferase PCAF; p300/CBP-associated factor

NP_003875.3

EC 2.3.1.48

XP_005265585.1

EC 2.3.1.48

XP_016862912.1

EC 2.3.1.48

XP_016862913.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003884.5 → NP_003875.3 histone acetyltransferase KAT2B

See identical proteins and their annotated locations for NP_003875.3

Status: REVIEWED

Source sequence(s)

AC099057

Consensus CDS

CCDS2634.1

UniProtKB/Swiss-Prot

Q92831

Related

ENSP00000263754.4, ENST00000263754.4

Conserved Domains (4) summary

cd05509
Location:727 → 826

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:487 → 826

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00583
Location:550 → 622

Acetyltransf_1; Acetyltransferase (GNAT) family

pfam06466
Location:74 → 325

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p12 Primary Assembly

Range

20040032..20154404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005265528.4 → XP_005265585.1 histone acetyltransferase KAT2B isoform X1

Conserved Domains (2) summary

pfam00583
Location:550 → 622

Acetyltransf_1; Acetyltransferase (GNAT) family

pfam06466
Location:74 → 325

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
XM_017007424.1 → XP_016862913.1 histone acetyltransferase KAT2B isoform X2

Conserved Domains (4) summary

cd05509
Location:630 → 729

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:390 → 729

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00583
Location:453 → 525

Acetyltransf_1; Acetyltransferase (GNAT) family

pfam06466
Location:7 → 228

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
XM_017007423.1 → XP_016862912.1 histone acetyltransferase KAT2B isoform X2

Conserved Domains (4) summary

cd05509
Location:630 → 729

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:390 → 729

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00583
Location:453 → 525

Acetyltransf_1; Acetyltransferase (GNAT) family

pfam06466
Location:7 → 228

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain