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KAT2B lysine acetyltransferase 2B [ Homo sapiens (human) ]

Gene ID: 8850, updated on 6-Apr-2021

Summary

Official Symbol
KAT2Bprovided by HGNC
Official Full Name
lysine acetyltransferase 2Bprovided by HGNC
Primary source
HGNC:HGNC:8638
See related
Ensembl:ENSG00000114166 MIM:602303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAF; PCAF; P/CAF
Summary
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 17.7), bone marrow (RPKM 16.3) and 25 other tissues See more
Orthologs
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Genomic context

See KAT2B in Genome Data Viewer
Location:
3p24.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (20040407..20154404)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (20081938..20195896)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr3.1018 Neighboring gene ribosomal protein L39 pseudogene 18 Neighboring gene microRNA 3135a Neighboring gene shugoshin 1 Neighboring gene SGO1 antisense RNA 1 Neighboring gene uncharacterized LOC107986067 Neighboring gene RNY4 pseudogene 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.
GeneReviews: Not available
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
GeneReviews: Not available
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
GeneReviews: Not available
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Acetylation of HIV-1 Tat by P/CAF at Lys28 and binding of P/CAF to Lys50 acetylated Tat regulates Tat binding to cyclin T1 and HIV-1 TAR RNA, as well as Tat-mediated transactivation of the HIV-1 LTR promoter, by allowing Tat to dissociate from TAR RNA PubMed
tat Acetylation of HIV-1 Tat by P/CAF at Lysine 28 enhances Tat binding to CDK9, indicating P/CAF may regulate Tat-mediated transactivation of the HIV-1 LTR PubMed
tat HIV-1 Tat is acetylated by P/CAF on Lysine 28 PubMed
tat Small-molecule inhibitors inbihit PCAF bromodomain/Tat-AcK50 protein-peptide interaction, potentially leads for the anti-HIV/AIDS therapeutic strategy PubMed
tat The K19A, K29R, and K41A mutations decrease HIV-1 Tat binding to PCAF, whereas the K12Q and K12R mutations increase the binding PubMed
tat HIV-1 Tat recruits P/CAF, as well as other known cellular acetyltransferases, to the HIV-1 LTR promoter, an effect involved in the acetylation of histones H3 and H4, and HIV-1 transcriptional activation PubMed
tat HIV-1 Tat interaction with P/CAF and other histone acetyl transferases is preferentially important for Tat-mediated transactivation of integrated, but not unintegrated, HIV-1 LTR promoter PubMed
tat HIV-1 Tat forms a ternary complex with p300 and P/CAF PubMed
tat HIV-1 Tat synergizes with P/CAF to activate the HIV-1 LTR promoter PubMed
tat Association of tumor protein p73 with HIV-1 Tat prevents the acetylation of Tat on lysine 28 by PCAF PubMed
tat Binding of HIV-1 Tat to P/CAF inhibits acetylation of p53 on Lysine320 leading to repression of p53-mediated promoter transactivation, suggesting a mechanism whereby Tat may impair tumor suppressor functions and favor neoplasia establishment during AIDS PubMed
tat The bromodomain (amino acids 712-832) of P/CAF mediates its binding to amino acids 20-40 of non-acetylated HIV-1 Tat, to amino acids 48-57 in the arginine rich motif of Lys50 acetylated Tat, while Lys28 acetylation of Tat abrogates P/CAF binding to Tat PubMed
tat HIV-1 Tat inhibits the transcriptional activation activity of P/CAF PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclin-dependent protein serine/threonine kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
diamine N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
Inferred from Direct Assay
more info
PubMed 
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISS
Inferred from Sequence or Structural Similarity
more info
 
peptide-lysine-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coregulator activity IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
N-terminal peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
Notch signaling pathway TAS
Traceable Author Statement
more info
 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K9 acetylation IEA
Inferred from Electronic Annotation
more info
 
internal peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
limb development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of centriole replication IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of rRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Notch signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription of Notch receptor target TAS
Traceable Author Statement
more info
 
protein acetylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein phosphopantetheinylation IEA
Inferred from Electronic Annotation
more info
 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
regulation of protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
A band IEA
Inferred from Electronic Annotation
more info
 
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
I band IEA
Inferred from Electronic Annotation
more info
 
PCAF complex NAS
Non-traceable Author Statement
more info
PubMed 
actomyosin IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
histone acetyltransferase KAT2B
Names
CREBBP-associated factor
K(lysine) acetyltransferase 2B
histone acetylase PCAF
histone acetyltransferase PCAF
p300/CBP-associated factor
spermidine acetyltransferase KAT2B
NP_003875.3
XP_005265585.1
XP_016862912.1
XP_016862913.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003884.5NP_003875.3  histone acetyltransferase KAT2B

    See identical proteins and their annotated locations for NP_003875.3

    Status: REVIEWED

    Source sequence(s)
    AC099057
    Consensus CDS
    CCDS2634.1
    UniProtKB/Swiss-Prot
    Q92831
    Related
    ENSP00000263754.4, ENST00000263754.5
    Conserved Domains (3) summary
    cd05509
    Location:727826
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:487826
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:75325
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    20040407..20154404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265528.4XP_005265585.1  histone acetyltransferase KAT2B isoform X1

    Conserved Domains (2) summary
    pfam00583
    Location:550622
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:74325
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
  2. XM_017007424.1XP_016862913.1  histone acetyltransferase KAT2B isoform X2

    Conserved Domains (4) summary
    cd05509
    Location:630729
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:390729
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:453525
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:7228
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
  3. XM_017007423.1XP_016862912.1  histone acetyltransferase KAT2B isoform X2

    Conserved Domains (4) summary
    cd05509
    Location:630729
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:390729
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00583
    Location:453525
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam06466
    Location:7228
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

RNA

  1. XR_245162.4 RNA Sequence

  2. XR_001740351.1 RNA Sequence

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