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INPP4B inositol polyphosphate-4-phosphatase type II B [ Homo sapiens (human) ]

Gene ID: 8821, updated on 7-Jul-2019

Summary

Official Symbol
INPP4Bprovided by HGNC
Official Full Name
inositol polyphosphate-4-phosphatase type II Bprovided by HGNC
Primary source
HGNC:HGNC:6075
See related
Ensembl:ENSG00000109452 MIM:607494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 24 other tissues See more
Orthologs

Genomic context

See INPP4B in Genome Data Viewer
Location:
4q31.21
Exon count:
35
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (142023160..142846535, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (142949181..143767604, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2276 Neighboring gene interleukin 15 Neighboring gene ribosomal protein L5 pseudogene 13 Neighboring gene LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated pseudogene 4 Neighboring gene uncharacterized LOC101927613 Neighboring gene uncharacterized LOC105377457 Neighboring gene uncharacterized LOC107986194 Neighboring gene LysM domain containing 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC132014

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
inositol polyphosphate 4-phosphatase type II; type II inositol 3,4-bisphosphate 4-phosphatase
Names
inositol polyphosphate 4-phosphatase II; 4-phosphatase II
inositol polyphosphate-4-phosphatase, type II, 105kDa
NP_001095139.1
NP_001317969.1
NP_003857.2
XP_005263380.1
XP_005263382.1
XP_011530693.1
XP_016864283.1
XP_016864284.1
XP_016864285.1
XP_016864286.1
XP_016864287.1
XP_024310041.1
XP_024310042.1
XP_024310043.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101669.2NP_001095139.1  inositol polyphosphate 4-phosphatase type II isoform 1

    See identical proteins and their annotated locations for NP_001095139.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC108077, AI198719, BC017924, BC072447, BP360389, BX649090, DA695719
    Consensus CDS
    CCDS3757.1
    UniProtKB/Swiss-Prot
    O15327
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  2. NM_001331040.1NP_001317969.1  inositol polyphosphate 4-phosphatase type II isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and includes an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and novel 3' UTR. It encodes isoform 2 which has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AC108077, BC072447, BG708971, BX649090, DA695719, DB555643
    Consensus CDS
    CCDS82958.1
    UniProtKB/Swiss-Prot
    O15327
    UniProtKB/TrEMBL
    E7EQN9
    Related
    ENSP00000422793.1, ENST00000509777.5
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  3. NM_003866.3NP_003857.2  inositol polyphosphate 4-phosphatase type II isoform 1

    See identical proteins and their annotated locations for NP_003857.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC108077, AI198719, BC017924, BC072447, BX649090, DA695719
    Consensus CDS
    CCDS3757.1
    UniProtKB/Swiss-Prot
    O15327
    Related
    ENSP00000425487.1, ENST00000513000.5
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    142023160..142846535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008794.1XP_016864283.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X3

    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  2. XM_024454275.1XP_024310043.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

    Related
    ENSP00000262992.4, ENST00000262992.8
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  3. XM_017008796.1XP_016864285.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X6

  4. XM_011532391.2XP_011530693.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_011530693.1

    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  5. XM_017008795.1XP_016864284.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X5

    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  6. XM_024454274.1XP_024310042.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  7. XM_024454273.1XP_024310041.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  8. XM_017008797.1XP_016864286.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X7

  9. XM_005263325.3XP_005263382.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X10

    Related
    ENSP00000426207.1, ENST00000511838.5
  10. XM_017008798.1XP_016864287.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X9

  11. XM_005263323.3XP_005263380.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

    Related
    ENSP00000421065.1, ENST00000514525.1

RNA

  1. XR_001741343.2 RNA Sequence

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