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Inpp4b inositol polyphosphate-4-phosphatase, type II [ Mus musculus (house mouse) ]

Gene ID: 234515, updated on 8-Feb-2024

Summary

Official Symbol
Inpp4bprovided by MGI
Official Full Name
inositol polyphosphate-4-phosphatase, type IIprovided by MGI
Primary source
MGI:MGI:2158925
See related
Ensembl:ENSMUSG00000037940 AllianceGenome:MGI:2158925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130107I17Rik
Summary
Enables lipid binding activity; phosphatidylinositol bisphosphate phosphatase activity; and phosphatidylinositol trisphosphate phosphatase activity. Acts upstream of or within several processes, including negative regulation of osteoclast differentiation; regulation of bone remodeling; and regulation of protein kinase B signaling. Located in Golgi apparatus. Is expressed in several structures, including brain; ear; genitourinary system; heart; and musculoskeletal system. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 1.6), cerebellum adult (RPKM 1.4) and 22 other tissues See more
Orthologs
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Genomic context

See Inpp4b in Genome Data Viewer
Location:
8 C2; 8 39.02 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (82068895..82865553)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (81342266..82134312)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coenzyme Q10 homolog B pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr8:83877485-83877786 Neighboring gene STARR-seq mESC enhancer starr_22053 Neighboring gene STARR-seq mESC enhancer starr_22054 Neighboring gene STARR-positive B cell enhancer mm9_chr8:83898997-83899298 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 51582 Neighboring gene STARR-positive B cell enhancer mm9_chr8:84002682-84002982 Neighboring gene STARR-seq mESC enhancer starr_22055 Neighboring gene STARR-seq mESC enhancer starr_22056 Neighboring gene SNARE-associated protein Snapin pseudogene Neighboring gene STARR-seq mESC enhancer starr_22059 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22060 Neighboring gene STARR-seq mESC enhancer starr_22061 Neighboring gene STARR-seq mESC enhancer starr_22062 Neighboring gene STARR-seq mESC enhancer starr_22063 Neighboring gene predicted gene, 53442 Neighboring gene predicted gene, 25267 Neighboring gene predicted gene 9520

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
type II inositol 3,4-bisphosphate 4-phosphatase
Names
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
phosphatidylinositol-3,4-bisphosphate 4-phosphatase
phosphoinositide 4-phosphatase
NP_001019788.1
NP_001284520.1
NP_001284522.1
NP_001284525.1
XP_006530917.1
XP_006530918.1
XP_006530919.1
XP_006530921.1
XP_006530924.1
XP_006530925.1
XP_006530926.1
XP_011246653.1
XP_011246654.1
XP_017168215.1
XP_017168217.1
XP_017168218.1
XP_030099350.1
XP_036009844.1
XP_036009845.1
XP_036009846.1
XP_036009847.1
XP_036009848.1
XP_036009849.1
XP_036009850.1
XP_036009851.1
XP_036009852.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024617.3NP_001019788.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 2

    See identical proteins and their annotated locations for NP_001019788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC115778, AK139397, BC064813, DQ296611
    Consensus CDS
    CCDS22446.1
    UniProtKB/Swiss-Prot
    Q6P1Y8
    UniProtKB/TrEMBL
    Q1A6U9
    Related
    ENSMUSP00000044466.7, ENSMUST00000042529.14
    Conserved Domains (1) summary
    cd04048
    Location:39158
    C2A_Copine; C2 domain first repeat in Copine
  2. NM_001297591.1NP_001284520.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 1

    See identical proteins and their annotated locations for NP_001284520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK139397, AK141502, DQ296613
    Consensus CDS
    CCDS80901.1
    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Related
    ENSMUSP00000150541.2, ENSMUST00000217122.2
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  3. NM_001297593.1NP_001284522.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon and uses an alternate last exon compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC121136, AK141502, DQ296611, DQ296612
    UniProtKB/TrEMBL
    Q1A6V0
    Conserved Domains (1) summary
    cl14603
    Location:25114
    C2; C2 domain
  4. NM_001297596.1NP_001284525.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 4

    See identical proteins and their annotated locations for NP_001284525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate last exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121136, AK141502, DQ296611
    Consensus CDS
    CCDS80902.1
    UniProtKB/TrEMBL
    E9PVM1, Q1A6V1
    Related
    ENSMUSP00000148972.2, ENSMUST00000215332.2
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    82068895..82865553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153952.1XP_036009845.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

    UniProtKB/TrEMBL
    Q1A6V1
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  2. XM_011248351.3XP_011246653.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_011246653.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  3. XM_036153951.1XP_036009844.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  4. XM_006530855.3XP_006530918.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006530918.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  5. XM_030243490.1XP_030099350.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

    UniProtKB/TrEMBL
    Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  6. XM_006530856.3XP_006530919.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006530919.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  7. XM_006530861.4XP_006530924.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X5

    UniProtKB/TrEMBL
    F8WJC1
    Conserved Domains (1) summary
    cl14603
    Location:25114
    C2; C2 domain
  8. XM_017312729.3XP_017168218.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

    UniProtKB/TrEMBL
    Q1A6V1
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  9. XM_006530858.4XP_006530921.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X3

    See identical proteins and their annotated locations for XP_006530921.1

    UniProtKB/TrEMBL
    E9PVM1, Q1A6V1
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  10. XM_036153959.1XP_036009852.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X10

    UniProtKB/TrEMBL
    Q1A6V1
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  11. XM_006530854.4XP_006530917.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006530917.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  12. XM_017312728.3XP_017168217.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

    UniProtKB/TrEMBL
    Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  13. XM_036153953.1XP_036009846.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X6

    UniProtKB/TrEMBL
    F8WJC1
    Conserved Domains (1) summary
    cl14603
    Location:2597
    C2; C2 domain
  14. XM_036153954.1XP_036009847.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X7

    UniProtKB/TrEMBL
    Q3URI3
    Related
    ENSMUSP00000150520.2, ENSMUST00000213285.2
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  15. XM_011248352.3XP_011246654.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_011246654.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  16. XM_017312726.2XP_017168215.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39175
    C2A_Copine; C2 domain first repeat in Copine
  17. XM_036153955.1XP_036009848.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

    UniProtKB/TrEMBL
    F8WJC1
  18. XM_036153958.1XP_036009851.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

    UniProtKB/TrEMBL
    F8WJC1
    Related
    ENSMUSP00000132156.2, ENSMUST00000170160.8
  19. XM_006530862.4XP_006530925.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

    See identical proteins and their annotated locations for XP_006530925.1

    UniProtKB/TrEMBL
    F8WJC1
  20. XM_036153956.1XP_036009849.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X9

    UniProtKB/TrEMBL
    Q1A6V0
  21. XM_006530863.5XP_006530926.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

    See identical proteins and their annotated locations for XP_006530926.1

    UniProtKB/TrEMBL
    F8WJC1
    Related
    ENSMUSP00000105477.3, ENSMUST00000109851.3
  22. XM_036153957.1XP_036009850.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X9

    UniProtKB/TrEMBL
    Q1A6V0