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IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens (human) ]

Gene ID: 8807, updated on 26-Oct-2022

Summary

Official Symbol
IL18RAPprovided by HGNC
Official Full Name
interleukin 18 receptor accessory proteinprovided by HGNC
Primary source
HGNC:HGNC:5989
See related
Ensembl:ENSG00000115607 MIM:604509; AllianceGenome:HGNC:5989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
Summary
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Expression
Biased expression in bone marrow (RPKM 26.2), appendix (RPKM 5.0) and 4 other tissues See more
Orthologs
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Genomic context

See IL18RAP in Genome Data Viewer
Location:
2q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (102418621..102452565)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102877486..102911541)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (103035081..103069025)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 18 receptor 1 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 pseudogene 5 Neighboring gene microRNA 4772 Neighboring gene solute carrier family 9 member A4 Neighboring gene solute carrier family 9 member A2 Neighboring gene uncharacterized LOC124905954

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
EBI GWAS Catalog
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
EBI GWAS Catalog
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog
Newly identified genetic risk variants for celiac disease related to the immune response.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC120589, MGC120590

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-18 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-18 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of interleukin-18 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-18 receptor accessory protein
Names
CD218 antigen-like family member B
IL-18 receptor accessory protein
IL-18 receptor beta
cluster of differentiation w218b
interleukin-1 receptor 7
interleukin-18 receptor beta
NP_001380415.1
NP_001380416.1
NP_001380417.1
NP_001380418.1
NP_003844.1
XP_011510390.1
XP_024308965.1
XP_024308966.1
XP_024308967.1
XP_024308969.1
XP_047302118.1
XP_047302119.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011481.1 RefSeqGene

    Range
    9367..38772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393486.1NP_001380415.1  interleukin-18 receptor accessory protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007248, AC007278
    Consensus CDS
    CCDS2061.1
    UniProtKB/Swiss-Prot
    Q53TU5
    Conserved Domains (4) summary
    pfam01582
    Location:419559
    TIR; TIR domain
    pfam18452
    Location:100155
    Ig_6; Immunoglobulin domain
    cd00096
    Location:251254
    Ig; Ig strand A [structural motif]
    cl11960
    Location:251354
    Ig; Immunoglobulin domain
  2. NM_001393487.1NP_001380416.1  interleukin-18 receptor accessory protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007248, AC007278
    Consensus CDS
    CCDS2061.1
    UniProtKB/Swiss-Prot
    Q53TU5
    Related
    ENSP00000510345.1, ENST00000687160.1
    Conserved Domains (4) summary
    pfam01582
    Location:419559
    TIR; TIR domain
    pfam18452
    Location:100155
    Ig_6; Immunoglobulin domain
    cd00096
    Location:251254
    Ig; Ig strand A [structural motif]
    cl11960
    Location:251354
    Ig; Immunoglobulin domain
  3. NM_001393488.1NP_001380417.1  interleukin-18 receptor accessory protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007248, AC007278
    Consensus CDS
    CCDS92824.1
    Conserved Domains (3) summary
    pfam01582
    Location:277417
    TIR; TIR domain
    cd00096
    Location:109112
    Ig; Ig strand A [structural motif]
    cl11960
    Location:109212
    Ig; Immunoglobulin domain
  4. NM_001393489.1NP_001380418.1  interleukin-18 receptor accessory protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007248, AC007278
    Consensus CDS
    CCDS92824.1
    Related
    ENSP00000387201.1, ENST00000409369.1
    Conserved Domains (3) summary
    pfam01582
    Location:277417
    TIR; TIR domain
    cd00096
    Location:109112
    Ig; Ig strand A [structural motif]
    cl11960
    Location:109212
    Ig; Immunoglobulin domain
  5. NM_003853.4NP_003844.1  interleukin-18 receptor accessory protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_003844.1

    Status: REVIEWED

    Source sequence(s)
    AC007248, AC007278
    Consensus CDS
    CCDS2061.1
    UniProtKB/Swiss-Prot
    O95256, Q53TU5
    Related
    ENSP00000264260.2, ENST00000264260.6
    Conserved Domains (4) summary
    pfam01582
    Location:419559
    TIR; TIR domain
    pfam18452
    Location:100155
    Ig_6; Immunoglobulin domain
    cd00096
    Location:251254
    Ig; Ig strand A [structural motif]
    cl11960
    Location:251354
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    102418621..102452565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453197.2XP_024308965.1  interleukin-18 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    Q53TU5
    Conserved Domains (4) summary
    pfam01582
    Location:419559
    TIR; TIR domain
    pfam18452
    Location:100155
    Ig_6; Immunoglobulin domain
    cd00096
    Location:251254
    Ig; Ig strand A [structural motif]
    cl11960
    Location:251354
    Ig; Immunoglobulin domain
  2. XM_047446162.1XP_047302118.1  interleukin-18 receptor accessory protein isoform X2

  3. XM_024453199.2XP_024308967.1  interleukin-18 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    Q53TU5
    Conserved Domains (4) summary
    pfam01582
    Location:419559
    TIR; TIR domain
    pfam18452
    Location:100155
    Ig_6; Immunoglobulin domain
    cd00096
    Location:251254
    Ig; Ig strand A [structural motif]
    cl11960
    Location:251354
    Ig; Immunoglobulin domain
  4. XM_024453198.2XP_024308966.1  interleukin-18 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    Q53TU5
    Conserved Domains (4) summary
    pfam01582
    Location:419559
    TIR; TIR domain
    pfam18452
    Location:100155
    Ig_6; Immunoglobulin domain
    cd00096
    Location:251254
    Ig; Ig strand A [structural motif]
    cl11960
    Location:251354
    Ig; Immunoglobulin domain
  5. XM_024453201.2XP_024308969.1  interleukin-18 receptor accessory protein isoform X1

    UniProtKB/Swiss-Prot
    Q53TU5
    Conserved Domains (4) summary
    pfam01582
    Location:419559
    TIR; TIR domain
    pfam18452
    Location:100155
    Ig_6; Immunoglobulin domain
    cd00096
    Location:251254
    Ig; Ig strand A [structural motif]
    cl11960
    Location:251354
    Ig; Immunoglobulin domain
  6. XM_047446163.1XP_047302119.1  interleukin-18 receptor accessory protein isoform X3

  7. XM_011512088.3XP_011510390.1  interleukin-18 receptor accessory protein isoform X2

    See identical proteins and their annotated locations for XP_011510390.1

    UniProtKB/Swiss-Prot
    O95256
    Conserved Domains (3) summary
    pfam01582
    Location:277417
    TIR; TIR domain
    cd00096
    Location:109112
    Ig; Ig strand A [structural motif]
    cl11960
    Location:109212
    Ig; Immunoglobulin domain

RNA

  1. XR_007083519.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    102877486..102911541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)