Format

Send to:

Choose Destination

SUCLA2 succinate-CoA ligase ADP-forming beta subunit [ Homo sapiens (human) ]

Gene ID: 8803, updated on 12-Aug-2018

Summary

Official Symbol
SUCLA2provided by HGNC
Official Full Name
succinate-CoA ligase ADP-forming beta subunitprovided by HGNC
Primary source
HGNC:HGNC:11448
See related
Ensembl:ENSG00000136143 MIM:603921; Vega:OTTHUMG00000016889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A-SCS; A-BETA; MTDPS5; SCS-betaA
Summary
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 24.1), fat (RPKM 23.0) and 25 other tissues See more
Orthologs

Genomic context

See SUCLA2 in Genome Data Viewer
Location:
13q14.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (47942656..48001326, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48516791..48612125, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27a pseudogene 8 Neighboring gene long intergenic non-protein coding RNA 444 Neighboring gene long intergenic non-protein coding RNA 562 Neighboring gene nudix hydrolase 15 Neighboring gene MED4 antisense RNA 1 Neighboring gene mediator complex subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of aging.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 NL4-3 replication is restricted by SUCLA2 as enhanced replication was discovered when SUCLA2 is deleted through CRISPR/Cas9 genome editing in primary CD4+ T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
succinate-CoA ligase (ADP-forming) activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
succinate metabolic process IEA
Inferred from Electronic Annotation
more info
 
succinyl-CoA metabolic process TAS
Traceable Author Statement
more info
PubMed 
succinyl-CoA pathway NAS
Non-traceable Author Statement
more info
PubMed 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Names
ATP-specific succinyl-CoA synthetase subunit beta
ATP-specific succinyl-CoA synthetase, beta subunit
mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta
renal carcinoma antigen NY-REN-39
succinate-CoA ligase beta subunit
succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
succinyl-CoA synthetase beta-A chain
NP_003841.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008241.1 RefSeqGene

    Range
    5001..63672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003850.2NP_003841.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_003841.1

    Status: REVIEWED

    Source sequence(s)
    AB035863, AL080096
    Consensus CDS
    CCDS9406.1
    UniProtKB/Swiss-Prot
    Q9P2R7
    UniProtKB/TrEMBL
    E5KS60, Q9Y4T0
    Related
    ENSP00000367923.3, OTTHUMP00000018384, ENST00000378654.8, OTTHUMT00000044852
    Conserved Domains (1) summary
    PRK00696
    Location:55445
    sucC; succinyl-CoA synthetase subunit beta; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    47942656..48001326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center