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Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 20916, updated on 19-Apr-2019

Summary

Official Symbol
Sucla2provided by MGI
Official Full Name
succinate-Coenzyme A ligase, ADP-forming, beta subunitprovided by MGI
Primary source
MGI:MGI:1306775
See related
Ensembl:ENSMUSG00000022110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A-SCS; SCS-betaA; 4930547K18Rik
Expression
Ubiquitous expression in heart adult (RPKM 50.4), testis adult (RPKM 42.5) and 26 other tissues See more
Orthologs

Genomic context

See Sucla2 in Genome Data Viewer
Location:
14; 14 D3
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (73552774..73596144)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (73952593..73995949)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 Neighboring gene predicted gene, 41209 Neighboring gene mediator complex subunit 4 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene coronin, actin binding protein 1B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate-CoA ligase (ADP-forming) activity ISO
Inferred from Sequence Orthology
more info
 
succinate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
succinate metabolic process ISO
Inferred from Sequence Orthology
more info
 
succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 
succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
Names
ATP-specific succinyl-CoA synthetase subunit beta
succinyl-CoA synthetase beta-A chain
NP_035636.1
XP_006518820.1
XP_006518821.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361638.1NP_001348567.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113198, AC155246
    Conserved Domains (1) summary
    cl25712
    Location:1311
    SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
  2. NM_011506.4NP_035636.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_035636.1

    Status: VALIDATED

    Source sequence(s)
    AC113198, AC155246
    Consensus CDS
    CCDS27271.1
    UniProtKB/Swiss-Prot
    Q9Z2I9
    Related
    ENSMUSP00000123765.1, ENSMUST00000160507.7
    Conserved Domains (3) summary
    PRK00696
    Location:55445
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:321441
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:55262
    ATP-grasp_2; ATP-grasp domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    73552774..73596144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518758.2XP_006518821.1  succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl25712
    Location:1311
    SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
  2. XM_006518757.2XP_006518820.1  succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X1

    Conserved Domains (3) summary
    PRK00696
    Location:92482
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:358478
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:92299
    ATP-grasp_2; ATP-grasp domain
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