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Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 20916, updated on 8-Jan-2023

Summary

Official Symbol
Sucla2provided by MGI
Official Full Name
succinate-Coenzyme A ligase, ADP-forming, beta subunitprovided by MGI
Primary source
MGI:MGI:1306775
See related
Ensembl:ENSMUSG00000022110 AllianceGenome:MGI:1306775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A-SCS; SCS-betaA; 4930547K18Rik
Summary
Predicted to enable succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study mitochondrial DNA depletion syndrome 5. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 50.4), testis adult (RPKM 42.5) and 26 other tissues See more
Orthologs
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Genomic context

See Sucla2 in Genome Data Viewer
Location:
14; 14 D3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (73790226..73833584)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (73552786..73596144)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 4 Neighboring gene nudix hydrolase 15 Neighboring gene predicted gene, 41209 Neighboring gene predicted gene, 24540 Neighboring gene ribosomal protein S6 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables succinate-CoA ligase (ADP-forming) activity ISO
Inferred from Sequence Orthology
more info
 
enables succinate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in succinate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
part_of succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of succinate-CoA ligase complex (ADP-forming) IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Names
ATP-specific succinyl-CoA synthetase subunit beta
succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
succinyl-CoA synthetase beta-A chain
NP_001348567.1
NP_035636.1
XP_006518820.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361638.1NP_001348567.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113198, AC155246
    Conserved Domains (1) summary
    cl25712
    Location:1311
    SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
  2. NM_011506.4NP_035636.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_035636.1

    Status: VALIDATED

    Source sequence(s)
    AC113198, AC155246
    Consensus CDS
    CCDS27271.1
    UniProtKB/Swiss-Prot
    Q8BGS6, Q9Z2I9
    UniProtKB/TrEMBL
    A0A8C6HNV6
    Related
    ENSMUSP00000123765.2, ENSMUST00000160507.8
    Conserved Domains (3) summary
    PRK00696
    Location:55445
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:321441
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:55262
    ATP-grasp_2; ATP-grasp domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    73790226..73833584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518757.4XP_006518820.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK00696
    Location:92482
    sucC; ADP-forming succinate--CoA ligase subunit beta