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FBP2 fructose-bisphosphatase 2 [ Homo sapiens (human) ]

Gene ID: 8789, updated on 11-Jun-2021

Summary

Official Symbol
FBP2provided by HGNC
Official Full Name
fructose-bisphosphatase 2provided by HGNC
Primary source
HGNC:HGNC:3607
See related
Ensembl:ENSG00000130957 MIM:603027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 15.5), esophagus (RPKM 4.0) and 3 other tissues See more
Orthologs
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Genomic context

See FBP2 in Genome Data Viewer
Location:
9q22.32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (94558720..94593824, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97321002..97356106, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 14B Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing pseudogene 1 Neighboring gene uncharacterized LOC107987100 Neighboring gene leishmanolysin like peptidase pseudogene Neighboring gene RNA, U6 small nuclear 669, pseudogene Neighboring gene prostate cancer associated transcript 7 Neighboring gene fructose-bisphosphatase 1 Neighboring gene uncharacterized LOC107987101

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of 15 loci influencing height in a Korean population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 Matrix activates fructose 1,6-bisphosphatase gene expression by induction of a 1alpha-hydroxylase activity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142192

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in gluconeogenesis TAS
Traceable Author Statement
more info
 
involved_in sucrose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
fructose-1,6-bisphosphatase isozyme 2
Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 2
FBPase 2
fructose-1,6-bisphosphatase 2
hexosediphosphatase
muscle FBPase
muscle fructose-bisphosphatase
NP_003828.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003837.4NP_003828.2  fructose-1,6-bisphosphatase isozyme 2

    See identical proteins and their annotated locations for NP_003828.2

    Status: REVIEWED

    Source sequence(s)
    AJ573829, BM686555, CR536483
    Consensus CDS
    CCDS6711.1
    UniProtKB/Swiss-Prot
    O00757
    Related
    ENSP00000364486.3, ENST00000375337.4
    Conserved Domains (1) summary
    cd00354
    Location:18329
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    94558720..94593824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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