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Fbp2 fructose bisphosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 14120, updated on 8-May-2024

Summary

Official Symbol
Fbp2provided by MGI
Official Full Name
fructose bisphosphatase 2provided by MGI
Primary source
MGI:MGI:95491
See related
Ensembl:ENSMUSG00000021456 AllianceGenome:MGI:95491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbp1; Fbp-1; Rae-30
Summary
Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity and identical protein binding activity. Predicted to be involved in several processes, including fructose 1,6-bisphosphate metabolic process; hexose metabolic process; and sucrose biosynthetic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb segment. Orthologous to human FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 74.4), placenta adult (RPKM 60.2) and 7 other tissues See more
Orthologs
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Genomic context

See Fbp2 in Genome Data Viewer
Location:
13 B3; 13 32.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (62984698..63006214, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (62836884..62858400, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25448 Neighboring gene STARR-seq mESC enhancer starr_34784 Neighboring gene malic enzyme 1, NADP(+)-dependent, cytosolic pseudogene Neighboring gene fructose bisphosphatase 1 Neighboring gene STARR-seq mESC enhancer starr_34785 Neighboring gene predicted gene, 38679 Neighboring gene STARR-seq mESC enhancer starr_34786 Neighboring gene predicted gene, 40981

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fructose 1,6-bisphosphate 1-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sucrose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fructose-1,6-bisphosphatase isozyme 2
Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 2
FBPase 2
FBPase muscle
muscle FBPase
NP_032020.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007994.4NP_032020.2  fructose-1,6-bisphosphatase isozyme 2

    See identical proteins and their annotated locations for NP_032020.2

    Status: VALIDATED

    Source sequence(s)
    AK146946
    Consensus CDS
    CCDS36698.1
    UniProtKB/Swiss-Prot
    P70695, Q91X26, Q9JK01, Q9JK02, Q9JK03, Q9JK04, Q9JK05, Q9JK06, Q9JK07, Q9JK08, Q9JK09, Q9QXB4, Q9QXB5, Q9QXB6, Q9QXD7
    UniProtKB/TrEMBL
    Q3TH92, Q3TKP4
    Related
    ENSMUSP00000021907.8, ENSMUST00000021907.9
    Conserved Domains (1) summary
    cd00354
    Location:18330
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    62984698..63006214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)