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SIGLEC5 sialic acid binding Ig like lectin 5 [ Homo sapiens (human) ]

Gene ID: 8778, updated on 8-Jul-2021

Summary

Official Symbol
SIGLEC5provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 5provided by HGNC
Primary source
HGNC:HGNC:10874
See related
Ensembl:ENSG00000268500 MIM:604200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5
Summary
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]
Expression
Biased expression in bone marrow (RPKM 12.5), spleen (RPKM 10.6) and 12 other tissues See more
Orthologs
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Genomic context

See SIGLEC5 in Genome Data Viewer
Location:
19q13.41
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51610960..51630428, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52114213..52133654, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 175 Neighboring gene long intergenic non-protein coding RNA 1530 Neighboring gene cytosolic thiouridylase subunit 1 homolog (S. pombe) pseudogene Neighboring gene ribosomal protein L9 pseudogene 33 Neighboring gene sialic acid binding Ig like lectin 14 Neighboring gene ribosomal protein L7 pseudogene 51

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-02)

ClinGen Genome Curation Page
Haploinsufficency

Dosage sensitivity unlikely (Last evaluated 2021-02-02)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 5
Names
CD33 antigen-like 2
OB-binding protein 2
obesity-binding protein 2
sialic acid-binding immunoglobulin-like lectin 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384708.1NP_001371637.1  sialic acid-binding Ig-like lectin 5 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC018755
    Conserved Domains (4) summary
    cd00096
    Location:254259
    Ig; Ig strand A [structural motif]
    cd05712
    Location:21140
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:146231
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
    cl11960
    Location:254331
    Ig; Immunoglobulin domain
  2. NM_001384709.1NP_001371638.1  sialic acid-binding Ig-like lectin 5 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC018755
    Conserved Domains (4) summary
    cd00096
    Location:254259
    Ig; Ig strand A [structural motif]
    cd05712
    Location:21140
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cd20987
    Location:146231
    IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
    cl11960
    Location:254331
    Ig; Immunoglobulin domain
  3. NM_003830.4NP_003821.1  sialic acid-binding Ig-like lectin 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003821.1

    Status: REVIEWED

    Source sequence(s)
    AC018755, U71383
    Consensus CDS
    CCDS33088.1
    UniProtKB/Swiss-Prot
    O15389
    Related
    ENSP00000507738.1, ENST00000683636.1
    Conserved Domains (4) summary
    cd00096
    Location:265321
    Ig; Immunoglobulin domain
    cd05712
    Location:21140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:259331
    IG_like; Immunoglobulin like
    cl11960
    Location:150216
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51610960..51630428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027419.1XP_016882908.1  sialic acid-binding Ig-like lectin 5 isoform X1

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