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ABCC3 ATP binding cassette subfamily C member 3 [ Homo sapiens (human) ]

Gene ID: 8714, updated on 17-Sep-2017
Official Symbol
ABCC3provided by HGNC
Official Full Name
ATP binding cassette subfamily C member 3provided by HGNC
Primary source
HGNC:HGNC:54
See related
Ensembl:ENSG00000108846 MIM:604323; Vega:OTTHUMG00000162245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17q21.33
Exon count:
32
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (50634843..50691704)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48712205..48769063)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CACNA1G antisense RNA 1 Neighboring gene calcium voltage-gated channel subunit alpha1 G Neighboring gene uncharacterized LOC101927253 Neighboring gene ankyrin repeat domain 40 Neighboring gene LUC7 like 3 pre-mRNA splicing factor

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
    ABC-family proteins mediated transport, organism-specific biosystemThe ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes agai...
  • Antifolate resistance, organism-specific biosystem (from KEGG)
    Antifolate resistance, organism-specific biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Antifolate resistance, conserved biosystem (from KEGG)
    Antifolate resistance, conserved biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Bile acid and bile salt metabolism, organism-specific biosystem (from REACTOME)
    Bile acid and bile salt metabolism, organism-specific biosystemIn a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily. Newly synthesized bile salts are secreted into the bile and released into the small intestine where they emulsi...
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Codeine and Morphine Metabolism, organism-specific biosystem (from WikiPathways)
    Codeine and Morphine Metabolism, organism-specific biosystemThe principal pathways for metabolism of codeine occur in the liver, although some metabolism occurs in the intestine and brain. Approximately 50-70% of codeine is converted to codeine-6-glucuronide ...
  • Constitutive Androstane Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Constitutive Androstane Receptor Pathway, organism-specific biosystemThe Constitutive Androstane Receptor (CAR) is a nuclear receptor and functions as a sensor for xenobiotics. It regulates transcription of genes encoding proteins in metabolism and excretion of xenobi...
  • Drug Induction of Bile Acid Pathway, organism-specific biosystem (from WikiPathways)
    Drug Induction of Bile Acid Pathway, organism-specific biosystem
    Drug Induction of Bile Acid Pathway
  • Fluoropyrimidine Activity, organism-specific biosystem (from WikiPathways)
    Fluoropyrimidine Activity, organism-specific biosystemThe main mechanism of 5-FU activation is conversion to fluorodeoxyuridine monophosphate (FdUMP) which inhibits the enzyme thymidylate synthase (TYMS), an important part of the folate-homocysteine cyc...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • NRF2 pathway, organism-specific biosystem (from WikiPathways)
    NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
  • Nuclear Receptors in Lipid Metabolism and Toxicity, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors in Lipid Metabolism and Toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
  • Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystemPhotodynamic therapy may induce an antioxidant response mediated by NFE2L2.
  • Recycling of bile acids and salts, organism-specific biosystem (from REACTOME)
    Recycling of bile acids and salts, organism-specific biosystemOf the 20-40 grams of bile salts released daily by the liver, all but approximately 0.5 grams are reabsorbed from the intestine, returned to the liver, and re-used. This recycling involves a series o...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686E22157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances TAS
Traceable Author Statement
more info
PubMed 
ATPase-coupled anion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
bile acid-exporting ATPase activity TAS
Traceable Author Statement
more info
 
organic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
xenobiotic-transporting ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
ATP hydrolysis coupled anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
canalicular bile acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
drug transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
transport TAS
Traceable Author Statement
more info
PubMed 
xenobiotic transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
canalicular multispecific organic anion transporter 2
Names
ATP-binding cassette sub-family C member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
canicular multispecific organic anion transporter
multi-specific organic anion transporter D
multidrug resistance associated protein
multidrug resistance-associated protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144070.1NP_001137542.1  canalicular multispecific organic anion transporter 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons and has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) is much shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC046126, BC050370, BC058907
    Consensus CDS
    CCDS45739.1
    UniProtKB/Swiss-Prot
    O15438
    UniProtKB/TrEMBL
    Q86VN9
    Related
    ENSP00000395160.1, OTTHUMP00000221668, ENST00000427699.5, OTTHUMT00000368084
    Conserved Domains (1) summary
    cl00549
    Location:317546
    ABC_membrane; ABC transporter transmembrane region
  2. NM_003786.3NP_003777.2  canalicular multispecific organic anion transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_003777.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB010887, BC046126, BC137347
    Consensus CDS
    CCDS32681.1
    UniProtKB/Swiss-Prot
    O15438
    Related
    ENSP00000285238.8, OTTHUMP00000221667, ENST00000285238.12, OTTHUMT00000368083
    Conserved Domains (1) summary
    cl26602
    Location:71526
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

    Range
    50634843..50691704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525423.1XP_011523725.1  canalicular multispecific organic anion transporter 2 isoform X1

    Conserved Domains (5) summary
    TIGR00957
    Location:71561
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:13221542
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:662863
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:10101275
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:488617
    ABC_membrane; ABC transporter transmembrane region
  2. XM_011525422.2XP_011523724.1  canalicular multispecific organic anion transporter 2 isoform X2

    Conserved Domains (5) summary
    TIGR00957
    Location:71497
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:12581478
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:598799
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:9461211
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:424553
    ABC_membrane; ABC transporter transmembrane region
  3. XM_005257763.3XP_005257820.1  canalicular multispecific organic anion transporter 2 isoform X3

    Conserved Domains (5) summary
    TIGR00957
    Location:71462
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:12231443
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:563764
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:9111176
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:286518
    ABC_membrane; ABC transporter transmembrane region
  4. XM_017025266.1XP_016880755.1  canalicular multispecific organic anion transporter 2 isoform X6

    Related
    ENSP00000427521.1, OTTHUMP00000221670, ENST00000505699.5, OTTHUMT00000368086
  5. XM_011525425.2XP_011523727.1  canalicular multispecific organic anion transporter 2 isoform X5

    Conserved Domains (7) summary
    cd03244
    Location:10451265
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:385586
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1121
    Location:400618
    ZnuC; ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]
    COG1132
    Location:7141280
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    pfam00664
    Location:733998
    ABC_membrane; ABC transporter transmembrane region
    pfam11244
    Location:34100
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00549
    Location:205340
    ABC_membrane; ABC transporter transmembrane region
  6. XM_017025265.1XP_016880754.1  canalicular multispecific organic anion transporter 2 isoform X5

    Conserved Domains (7) summary
    cd03244
    Location:10451265
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:385586
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1121
    Location:400618
    ZnuC; ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]
    COG1132
    Location:7141280
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    pfam00664
    Location:733998
    ABC_membrane; ABC transporter transmembrane region
    pfam11244
    Location:34100
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00549
    Location:205340
    ABC_membrane; ABC transporter transmembrane region
  7. XM_011525424.2XP_011523726.1  canalicular multispecific organic anion transporter 2 isoform X4

    Conserved Domains (5) summary
    cd03244
    Location:10621282
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:402603
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:51292
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:7501015
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:92357
    ABC_membrane; ABC transporter transmembrane region

RNA

  1. XR_001752674.1 RNA Sequence

  2. XR_934586.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    48776209..48833053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020037.1: Suppressed sequence

    Description
    NM_020037.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_020038.1: Suppressed sequence

    Description
    NM_020038.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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