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ABCC3 ATP binding cassette subfamily C member 3 [ Homo sapiens (human) ]

Gene ID: 8714, updated on 24-Nov-2020

Summary

Official Symbol
ABCC3provided by HGNC
Official Full Name
ATP binding cassette subfamily C member 3provided by HGNC
Primary source
HGNC:HGNC:54
See related
Ensembl:ENSG00000108846 MIM:604323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in adrenal (RPKM 32.2), stomach (RPKM 26.9) and 18 other tissues See more
Orthologs

Genomic context

See ABCC3 in Genome Data Viewer
Location:
17q21.33
Exon count:
31
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50634881..50692253)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48712205..48769063)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CACNA1G antisense RNA 1 Neighboring gene calcium voltage-gated channel subunit alpha1 G Neighboring gene uncharacterized LOC101927253 Neighboring gene ABCC3 (B) eExon liver enhancer Neighboring gene ankyrin repeat domain 40 Neighboring gene LUC7 like 3 pre-mRNA splicing factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686E22157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase-coupled bile acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase-coupled xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
xenobiotic transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
canalicular bile acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
drug transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
xenobiotic transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
canalicular multispecific organic anion transporter 2
Names
ATP-binding cassette sub-family C member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
canicular multispecific organic anion transporter
multi-specific organic anion transporter D
multidrug resistance associated protein
multidrug resistance-associated protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144070.2NP_001137542.1  canalicular multispecific organic anion transporter 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons and has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) is much shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC046126, BC050370, BC058907
    Consensus CDS
    CCDS45739.1
    UniProtKB/Swiss-Prot
    O15438
    UniProtKB/TrEMBL
    Q86VN9
    Related
    ENSP00000395160.1, ENST00000427699.5
    Conserved Domains (1) summary
    cl00549
    Location:317546
    ABC_membrane; ABC transporter transmembrane region
  2. NM_003786.4NP_003777.2  canalicular multispecific organic anion transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_003777.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB010887, AC005921, BC046126, BC137347
    Consensus CDS
    CCDS32681.1
    UniProtKB/Swiss-Prot
    O15438
    Related
    ENSP00000285238.8, ENST00000285238.13
    Conserved Domains (1) summary
    cl26602
    Location:71526
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50634881..50692253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020037.1: Suppressed sequence

    Description
    NM_020037.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_020038.1: Suppressed sequence

    Description
    NM_020038.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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