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B4GALT4 beta-1,4-galactosyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 8702, updated on 21-Dec-2019

Summary

Official Symbol
B4GALT4provided by HGNC
Official Full Name
beta-1,4-galactosyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:927
See related
Ensembl:ENSG00000121578 MIM:604015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B4Gal-T4; beta4Gal-T4
Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in gall bladder (RPKM 16.8), colon (RPKM 15.3) and 25 other tissues See more
Orthologs

Genomic context

See B4GALT4 in Genome Data Viewer
Location:
3q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (119211742..119240907, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (118930589..118959754, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene testis expressed 55 Neighboring gene uroplakin 1B Neighboring gene B4GALT4 antisense RNA 1 Neighboring gene Rho GTPase activating protein 31 Neighboring gene ribosomal protein S26 pseudogene 21 Neighboring gene ARHGAP31 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetyllactosamine synthase activity IEA
Inferred from Electronic Annotation
more info
 
galactosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
membrane lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-1,4-galactosyltransferase 4
Names
N-acetyllactosamine synthase
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
beta-1,4-GalTase 4
beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 4
lactotriaosylceramide beta-1,4-galactosyltransferase
nal synthase
NP_003769.1
NP_997708.1
XP_005247912.1
XP_006713861.1
XP_006713862.1
XP_006713863.1
XP_006713864.1
XP_011511562.1
XP_016862890.1
XP_024309572.1
XP_024309573.1
XP_024309574.1
XP_024309575.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003778.4NP_003769.1  beta-1,4-galactosyltransferase 4

    See identical proteins and their annotated locations for NP_003769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF038662, AK001006, AK123182, BX647468
    Consensus CDS
    CCDS2986.1
    UniProtKB/Swiss-Prot
    O60513
    UniProtKB/TrEMBL
    B2RAZ5, B3KM35
    Related
    ENSP00000377360.2, ENST00000393765.7
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  2. NM_212543.2NP_997708.1  beta-1,4-galactosyltransferase 4

    See identical proteins and their annotated locations for NP_997708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AF038662, AK001006, AK123182, AU099090
    Consensus CDS
    CCDS2986.1
    UniProtKB/Swiss-Prot
    O60513
    UniProtKB/TrEMBL
    B2RAZ5, B3KM35
    Related
    ENSP00000352144.3, ENST00000359213.7
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    119211742..119240907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713798.3XP_006713861.1  beta-1,4-galactosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006713861.1

    UniProtKB/Swiss-Prot
    O60513
    UniProtKB/TrEMBL
    B2RAZ5
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  2. XM_006713801.3XP_006713864.1  beta-1,4-galactosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006713864.1

    UniProtKB/Swiss-Prot
    O60513
    UniProtKB/TrEMBL
    B2RAZ5
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  3. XM_006713799.3XP_006713862.1  beta-1,4-galactosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006713862.1

    UniProtKB/Swiss-Prot
    O60513
    UniProtKB/TrEMBL
    B2RAZ5
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  4. XM_017007401.1XP_016862890.1  beta-1,4-galactosyltransferase 4 isoform X2

  5. XM_011513260.1XP_011511562.1  beta-1,4-galactosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_011511562.1

    UniProtKB/Swiss-Prot
    O60513
    UniProtKB/TrEMBL
    B2RAZ5
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  6. XM_005247855.1XP_005247912.1  beta-1,4-galactosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_005247912.1

    UniProtKB/Swiss-Prot
    O60513
    UniProtKB/TrEMBL
    B2RAZ5
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  7. XM_024453806.1XP_024309574.1  beta-1,4-galactosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  8. XM_006713800.2XP_006713863.1  beta-1,4-galactosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006713863.1

    UniProtKB/Swiss-Prot
    O60513
    UniProtKB/TrEMBL
    B2RAZ5
    Related
    ENSP00000420161.1, ENST00000483209.5
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  9. XM_024453805.1XP_024309573.1  beta-1,4-galactosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  10. XM_024453807.1XP_024309575.1  beta-1,4-galactosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  11. XM_024453804.1XP_024309572.1  beta-1,4-galactosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RNA

  1. XR_001740340.1 RNA Sequence

    Related
    ENST00000480814.5
  2. XR_001740345.1 RNA Sequence

  3. XR_001740343.1 RNA Sequence

  4. XR_001740342.2 RNA Sequence

  5. XR_001740346.2 RNA Sequence

  6. XR_001740344.2 RNA Sequence

  7. XR_002959604.1 RNA Sequence

  8. XR_001740341.2 RNA Sequence

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