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B4galt4 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 56375, updated on 3-Jan-2023

Summary

Official Symbol
B4galt4provided by MGI
Official Full Name
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4provided by MGI
Primary source
MGI:MGI:1928387
See related
Ensembl:ENSMUSG00000022793 AllianceGenome:MGI:1928387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b4Gal-T4; B4galt-IV; beta4Gal-T4; beta4GalT-IV; 9130402O08Rik
Summary
Predicted to enable galactosyltransferase activity. Predicted to be involved in glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in gland and thyroid gland. Orthologous to human B4GALT4 (beta-1,4-galactosyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 9.5), colon adult (RPKM 7.0) and 26 other tissues See more
Orthologs
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Genomic context

See B4galt4 in Genome Data Viewer
Location:
16; 16 B4
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38562600..38589416)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38742220..38769054)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 31 Neighboring gene predicted gene, 36482 Neighboring gene anaphase promoting complex subunit 10 pseudogene Neighboring gene RNA binding motif protein 39 pseudogene Neighboring gene uroplakin 1B Neighboring gene testis expressed 55

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosamine synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables UDP-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in keratan sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lactosylceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-1,4-galactosyltransferase 4
Names
N-acetyllactosamine synthase
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
beta-1,4-GalTase 4
beta-1,4-galactosyltransferase IV
beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
lactotriaosylceramide beta-1,4-galactosyltransferase
nal synthase
NP_001272722.1
NP_062778.2
XP_006522462.1
XP_011244279.1
XP_036015930.1
XP_036015931.1
XP_036015932.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285793.1NP_001272722.1  beta-1,4-galactosyltransferase 4 precursor

    See identical proteins and their annotated locations for NP_001272722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK053603, CT009576
    Consensus CDS
    CCDS28173.1
    UniProtKB/Swiss-Prot
    Q9JJ04, Q9QY12
    Related
    ENSMUSP00000110360.2, ENSMUST00000114712.8
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  2. NM_019804.4NP_062778.2  beta-1,4-galactosyltransferase 4 precursor

    See identical proteins and their annotated locations for NP_062778.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK050005, BY283636, CT009576
    Consensus CDS
    CCDS28173.1
    UniProtKB/Swiss-Prot
    Q9JJ04, Q9QY12
    Related
    ENSMUSP00000023482.7, ENSMUST00000023482.13
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RNA

  1. NR_152434.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CT009576
    Related
    ENSMUST00000154902.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    38562600..38589416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160039.1XP_036015932.1  beta-1,4-galactosyltransferase 4 isoform X2

    Conserved Domains (1) summary
    cl11394
    Location:122298
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  2. XM_036160038.1XP_036015931.1  beta-1,4-galactosyltransferase 4 isoform X2

    Conserved Domains (1) summary
    cl11394
    Location:122298
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  3. XM_006522399.5XP_006522462.1  beta-1,4-galactosyltransferase 4 isoform X3

    See identical proteins and their annotated locations for XP_006522462.1

    UniProtKB/Swiss-Prot
    Q9JJ04, Q9QY12
    Conserved Domains (1) summary
    cd00899
    Location:122339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  4. XM_011245977.3XP_011244279.1  beta-1,4-galactosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_011244279.1

    Conserved Domains (1) summary
    cd00899
    Location:186403
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
  5. XM_036160037.1XP_036015930.1  beta-1,4-galactosyltransferase 4 isoform X2

    Conserved Domains (1) summary
    cl11394
    Location:122298
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RNA

  1. XR_003951806.2 RNA Sequence

  2. XR_003951807.2 RNA Sequence

  3. XR_875837.3 RNA Sequence