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GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 8693, updated on 1-Jun-2020

Summary

Official Symbol
GALNT4provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:4126
See related
Ensembl:ENSG00000257594 MIM:603565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GALNACT4; GALNAC-T4
Summary
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5' exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist. [provided by RefSeq, Dec 2010]
Orthologs

Genomic context

See GALNT4 in Genome Data Viewer
Location:
12q21.33
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (89519412..89524796, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (89913189..89918583, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 6 Neighboring gene POC1 centriolar protein B Neighboring gene POC1B-GALNT4 readthrough Neighboring gene centromere protein C pseudogene 1 Neighboring gene POC1B antisense RNA 1 Neighboring gene ATPase plasma membrane Ca2+ transporting 1 Neighboring gene ATP2B1 antisense RNA 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough POC1B-GALNT4

Readthrough gene: POC1B-GALNT4, Included gene: POC1B

Homology

Clone Names

  • FLJ93314

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
protein O-linked glycosylation via serine IDA
Inferred from Direct Assay
more info
PubMed 
protein O-linked glycosylation via threonine IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polypeptide N-acetylgalactosaminyltransferase 4
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
polypeptide GalNAc transferase 4
pp-GaNTase 4
protein-UDP acetylgalactosaminyltransferase 4
NP_003765.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050753.1 RefSeqGene

    Range
    5011..10395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003774.5NP_003765.2  polypeptide N-acetylgalactosaminyltransferase 4

    See identical proteins and their annotated locations for NP_003765.2

    Status: REVIEWED

    Source sequence(s)
    BC036390, CR739813, DA109687
    Consensus CDS
    CCDS53817.1
    UniProtKB/Swiss-Prot
    Q8N4A0
    Related
    ENSP00000436604.2, ENST00000529983.3
    Conserved Domains (2) summary
    cd02510
    Location:138432
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:446574
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    89519412..89524796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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