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CBLB Cbl proto-oncogene B [ Homo sapiens (human) ]

Gene ID: 868, updated on 13-Jan-2019

Summary

Official Symbol
CBLBprovided by HGNC
Official Full Name
Cbl proto-oncogene Bprovided by HGNC
Primary source
HGNC:HGNC:1542
See related
Ensembl:ENSG00000114423 MIM:604491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cbl-b; RNF56; Nbla00127
Summary
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
Expression
Ubiquitous expression in lymph node (RPKM 6.7), gall bladder (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See CBLB in Genome Data Viewer
Location:
3q13.11
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (105655461..105869552, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (105374306..105589354, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374023 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC107986109 Neighboring gene uncharacterized LOC105374024 Neighboring gene uncharacterized LOC105374026

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of Cbl proto-oncogene B, E3 ubiquitin protein ligase (CBLB) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystem (from REACTOME)
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel e...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
    Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
    Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
    CD40/CD40L signaling, organism-specific biosystem
    CD40/CD40L signaling
  • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
  • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
    Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Chronic myeloid leukemia, conserved biosystem (from KEGG)
    Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
    Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
    Fc-epsilon receptor I signaling in mast cells
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
    Internalization of ErbB1, organism-specific biosystem
    Internalization of ErbB1
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36865, FLJ41152, DKFZp779A0729, DKFZp779F1443, DKFZp686J10223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase CBL-B
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Cbl proto-oncogene B, E3 ubiquitin protein ligase
Cbl proto-oncogene, E3 ubiquitin protein ligase B
RING finger protein 56
RING-type E3 ubiquitin transferase CBL-B
SH3-binding protein CBL-B
casitas B-lineage lymphoma proto-oncogene b
signal transduction protein CBL-B
NP_001308715.1
NP_001308717.1
NP_001308718.1
NP_001308719.1
NP_001308720.1
NP_001308722.1
NP_001308723.1
NP_001308724.1
NP_001308725.1
NP_001308726.1
NP_001308727.1
NP_001308728.1
NP_001308735.1
NP_001308736.1
NP_001308737.1
NP_001308740.1
NP_001308742.1
NP_001308745.1
NP_001308749.1
NP_001308751.1
NP_733762.2
XP_011511559.1
XP_011511561.2
XP_016862884.1
XP_016862885.1
XP_016862886.1
XP_016862887.1
XP_016862888.1
XP_016862889.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055547.1 RefSeqGene

    Range
    5541..219092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1179

mRNA and Protein(s)

  1. NM_001321786.1NP_001308715.1  E3 ubiquitin-protein ligase CBL-B isoform a

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Consensus CDS
    CCDS87116.1
    Conserved Domains (5) summary
    cd09920
    Location:276372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:401443
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:959999
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:72195
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:199282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  2. NM_001321788.1NP_001308717.1  E3 ubiquitin-protein ligase CBL-B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Consensus CDS
    CCDS2948.1
    UniProtKB/Swiss-Prot
    Q13191
    Related
    ENSP00000496761.1, ENST00000646825.1
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  3. NM_001321789.1NP_001308718.1  E3 ubiquitin-protein ligase CBL-B isoform c

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:276372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:401443
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:910950
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:72195
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:199282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  4. NM_001321790.1NP_001308719.1  E3 ubiquitin-protein ligase CBL-B isoform d

    Status: REVIEWED

    Source sequence(s)
    AC016138, AI221219, AK302533, AK316276
    UniProtKB/TrEMBL
    B4DYP3, B7ZAG1
    Conserved Domains (5) summary
    cd09920
    Location:270366
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:395437
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:909949
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:66189
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:193276
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  5. NM_001321791.1NP_001308720.1  E3 ubiquitin-protein ligase CBL-B isoform e

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6 and 7 encode the same isoform (e).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:887927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  6. NM_001321793.1NP_001308722.1  E3 ubiquitin-protein ligase CBL-B isoform e

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6 and 7 encode the same isoform (e).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:887927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  7. NM_001321794.1NP_001308723.1  E3 ubiquitin-protein ligase CBL-B isoform f

    Status: REVIEWED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  8. NM_001321795.1NP_001308724.1  E3 ubiquitin-protein ligase CBL-B isoform f

    Status: REVIEWED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  9. NM_001321796.1NP_001308725.1  E3 ubiquitin-protein ligase CBL-B isoform g

    Status: REVIEWED

    Description
    Transcript Variant: Isoform g is the same length as isoform f but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485
    Conserved Domains (5) summary
    cd09920
    Location:199295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:324366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:123205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  10. NM_001321797.1NP_001308726.1  E3 ubiquitin-protein ligase CBL-B isoform h

    Status: REVIEWED

    Description
    Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  11. NM_001321798.1NP_001308727.1  E3 ubiquitin-protein ligase CBL-B isoform h

    Status: REVIEWED

    Description
    Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  12. NM_001321799.1NP_001308728.1  E3 ubiquitin-protein ligase CBL-B isoform i

    Status: REVIEWED

    Description
    Transcript Variant: Isoform i is the same length as isoform h but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485
    Conserved Domains (5) summary
    cd09920
    Location:199295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:324366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:123205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  13. NM_001321806.1NP_001308735.1  E3 ubiquitin-protein ligase CBL-B isoform j

    Status: REVIEWED

    Description
    Transcript Variant: Variants 14 and 15 encode the same isoform (j).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:671711
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  14. NM_001321807.1NP_001308736.1  E3 ubiquitin-protein ligase CBL-B isoform j

    Status: REVIEWED

    Description
    Transcript Variant: Variants 14 and 15 encode the same isoform (j).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:671711
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  15. NM_001321808.1NP_001308737.1  E3 ubiquitin-protein ligase CBL-B isoform k

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:627667
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  16. NM_001321811.1NP_001308740.1  E3 ubiquitin-protein ligase CBL-B isoform l

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (l).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:622662
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  17. NM_001321813.1NP_001308742.1  E3 ubiquitin-protein ligase CBL-B isoform l

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (l).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:622662
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  18. NM_001321816.1NP_001308745.1  E3 ubiquitin-protein ligase CBL-B isoform m

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:578618
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  19. NM_001321820.1NP_001308749.1  E3 ubiquitin-protein ligase CBL-B isoform n

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (1) summary
    cd14392
    Location:491531
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  20. NM_001321822.1NP_001308751.1  E3 ubiquitin-protein ligase CBL-B isoform o

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (1) summary
    cd14392
    Location:488528
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  21. NM_170662.5NP_733762.2  E3 ubiquitin-protein ligase CBL-B isoform b

    See identical proteins and their annotated locations for NP_733762.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AC016138, AI221219, AK094184, BC032851, BC065915, U26710
    Consensus CDS
    CCDS2948.1
    UniProtKB/Swiss-Prot
    Q13191
    UniProtKB/TrEMBL
    B3KSS7
    Related
    ENSP00000264122.4, ENST00000264122.8
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

RNA

  1. NR_135806.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  2. NR_135807.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  3. NR_135808.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  4. NR_135809.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  5. NR_135810.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  6. NR_135811.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Related
    ENST00000645759.1
  7. NR_135812.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    105655461..105869552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513257.1XP_011511559.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    See identical proteins and their annotated locations for XP_011511559.1

    UniProtKB/Swiss-Prot
    Q13191
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  2. XM_017007395.1XP_016862884.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    Related
    ENSP00000496352.1, ENST00000643322.1
  3. XM_017007398.1XP_016862887.1  E3 ubiquitin-protein ligase CBL-B isoform X5

  4. XM_017007399.1XP_016862888.1  E3 ubiquitin-protein ligase CBL-B isoform X6

    Conserved Domains (5) summary
    cd09920
    Location:199295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:324366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:123205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  5. XM_017007400.1XP_016862889.1  E3 ubiquitin-protein ligase CBL-B isoform X7

  6. XM_017007397.1XP_016862886.1  E3 ubiquitin-protein ligase CBL-B isoform X4

  7. XM_017007396.1XP_016862885.1  E3 ubiquitin-protein ligase CBL-B isoform X3

  8. XM_011513259.3XP_011511561.2  E3 ubiquitin-protein ligase CBL-B isoform X8

    Related
    ENSP00000384938.1, ENST00000405772.5

RNA

  1. XR_001740339.1 RNA Sequence

  2. XR_001740338.1 RNA Sequence

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