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CBLB Cbl proto-oncogene B [ Homo sapiens (human) ]

Gene ID: 868, updated on 1-Jun-2020

Summary

Official Symbol
CBLBprovided by HGNC
Official Full Name
Cbl proto-oncogene Bprovided by HGNC
Primary source
HGNC:HGNC:1542
See related
Ensembl:ENSG00000114423 MIM:604491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cbl-b; RNF56; Nbla00127
Summary
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
Expression
Ubiquitous expression in lymph node (RPKM 6.7), gall bladder (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See CBLB in Genome Data Viewer
Location:
3q13.11
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (105655461..105869552, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (105374306..105589354, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374023 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC107986109 Neighboring gene uncharacterized LOC105374024 Neighboring gene uncharacterized LOC105374026

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of Cbl proto-oncogene B, E3 ubiquitin protein ligase (CBLB) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36865, FLJ41152, DKFZp779A0729, DKFZp779F1443, DKFZp686J10223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase CBL-B
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Cbl proto-oncogene B, E3 ubiquitin protein ligase
Cbl proto-oncogene, E3 ubiquitin protein ligase B
RING finger protein 56
RING-type E3 ubiquitin transferase CBL-B
SH3-binding protein CBL-B
casitas B-lineage lymphoma proto-oncogene b
signal transduction protein CBL-B
NP_001308715.1
NP_001308717.1
NP_001308718.1
NP_001308719.1
NP_001308720.1
NP_001308722.1
NP_001308723.1
NP_001308724.1
NP_001308725.1
NP_001308726.1
NP_001308727.1
NP_001308728.1
NP_001308735.1
NP_001308736.1
NP_001308737.1
NP_001308740.1
NP_001308742.1
NP_001308745.1
NP_001308749.1
NP_001308751.1
NP_733762.2
XP_011511559.1
XP_011511561.2
XP_016862884.1
XP_016862885.1
XP_016862886.1
XP_016862887.1
XP_016862888.1
XP_016862889.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055547.1 RefSeqGene

    Range
    5541..219092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1179

mRNA and Protein(s)

  1. NM_001321786.1NP_001308715.1  E3 ubiquitin-protein ligase CBL-B isoform a

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Consensus CDS
    CCDS87116.1
    Conserved Domains (5) summary
    cd09920
    Location:276372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:401443
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:959999
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:72195
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:199282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  2. NM_001321788.2NP_001308717.1  E3 ubiquitin-protein ligase CBL-B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Consensus CDS
    CCDS2948.1
    UniProtKB/Swiss-Prot
    Q13191
    Related
    ENSP00000496761.1, ENST00000646825.1
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  3. NM_001321789.1NP_001308718.1  E3 ubiquitin-protein ligase CBL-B isoform c

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:276372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:401443
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:910950
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:72195
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:199282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  4. NM_001321790.2NP_001308719.1  E3 ubiquitin-protein ligase CBL-B isoform d

    Status: REVIEWED

    Source sequence(s)
    AC016138, AI221219, AK302533, AK316276
    UniProtKB/TrEMBL
    B4DYP3, B7ZAG1
    Conserved Domains (5) summary
    cd09920
    Location:270366
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:395437
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:909949
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:66189
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:193276
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  5. NM_001321791.2NP_001308720.1  E3 ubiquitin-protein ligase CBL-B isoform e

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6 and 7 encode the same isoform (e).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:887927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  6. NM_001321793.2NP_001308722.1  E3 ubiquitin-protein ligase CBL-B isoform e

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6 and 7 encode the same isoform (e).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:887927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  7. NM_001321794.2NP_001308723.1  E3 ubiquitin-protein ligase CBL-B isoform f

    Status: REVIEWED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  8. NM_001321795.2NP_001308724.1  E3 ubiquitin-protein ligase CBL-B isoform f

    Status: REVIEWED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  9. NM_001321796.2NP_001308725.1  E3 ubiquitin-protein ligase CBL-B isoform g

    Status: REVIEWED

    Description
    Transcript Variant: Isoform g is the same length as isoform f but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485
    Conserved Domains (5) summary
    cd09920
    Location:199295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:324366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:123205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  10. NM_001321797.2NP_001308726.1  E3 ubiquitin-protein ligase CBL-B isoform h

    Status: REVIEWED

    Description
    Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  11. NM_001321798.2NP_001308727.1  E3 ubiquitin-protein ligase CBL-B isoform h

    Status: REVIEWED

    Description
    Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  12. NM_001321799.2NP_001308728.1  E3 ubiquitin-protein ligase CBL-B isoform i

    Status: REVIEWED

    Description
    Transcript Variant: Isoform i is the same length as isoform h but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485
    Conserved Domains (5) summary
    cd09920
    Location:199295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:324366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:123205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  13. NM_001321806.2NP_001308735.1  E3 ubiquitin-protein ligase CBL-B isoform j

    Status: REVIEWED

    Description
    Transcript Variant: Variants 14 and 15 encode the same isoform (j).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:671711
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  14. NM_001321807.2NP_001308736.1  E3 ubiquitin-protein ligase CBL-B isoform j

    Status: REVIEWED

    Description
    Transcript Variant: Variants 14 and 15 encode the same isoform (j).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:671711
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  15. NM_001321808.2NP_001308737.1  E3 ubiquitin-protein ligase CBL-B isoform k

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:627667
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  16. NM_001321811.2NP_001308740.1  E3 ubiquitin-protein ligase CBL-B isoform l

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (l).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:622662
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  17. NM_001321813.1NP_001308742.1  E3 ubiquitin-protein ligase CBL-B isoform l

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (l).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:622662
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  18. NM_001321816.2NP_001308745.1  E3 ubiquitin-protein ligase CBL-B isoform m

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:578618
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  19. NM_001321820.2NP_001308749.1  E3 ubiquitin-protein ligase CBL-B isoform n

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (1) summary
    cd14392
    Location:491531
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  20. NM_001321822.2NP_001308751.1  E3 ubiquitin-protein ligase CBL-B isoform o

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (1) summary
    cd14392
    Location:488528
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  21. NM_170662.5NP_733762.2  E3 ubiquitin-protein ligase CBL-B isoform b

    See identical proteins and their annotated locations for NP_733762.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AC016138, AI221219, AK094184, BC032851, BC065915, U26710
    Consensus CDS
    CCDS2948.1
    UniProtKB/Swiss-Prot
    Q13191
    UniProtKB/TrEMBL
    B3KSS7
    Related
    ENSP00000377598.4, ENST00000394030.8
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

RNA

  1. NR_135806.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  2. NR_135807.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  3. NR_135808.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  4. NR_135809.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  5. NR_135810.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
  6. NR_135811.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Related
    ENST00000645759.1
  7. NR_135812.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    105655461..105869552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513257.1XP_011511559.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    See identical proteins and their annotated locations for XP_011511559.1

    UniProtKB/Swiss-Prot
    Q13191
    Conserved Domains (5) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  2. XM_017007395.1XP_016862884.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    Related
    ENSP00000496352.1, ENST00000643322.1
  3. XM_017007398.1XP_016862887.1  E3 ubiquitin-protein ligase CBL-B isoform X5

  4. XM_017007399.1XP_016862888.1  E3 ubiquitin-protein ligase CBL-B isoform X6

    Conserved Domains (5) summary
    cd09920
    Location:199295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:324366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:123205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  5. XM_017007400.1XP_016862889.1  E3 ubiquitin-protein ligase CBL-B isoform X7

  6. XM_017007397.1XP_016862886.1  E3 ubiquitin-protein ligase CBL-B isoform X4

  7. XM_017007396.1XP_016862885.1  E3 ubiquitin-protein ligase CBL-B isoform X3

  8. XM_011513259.3XP_011511561.2  E3 ubiquitin-protein ligase CBL-B isoform X8

    Related
    ENSP00000384938.1, ENST00000405772.5

RNA

  1. XR_001740339.1 RNA Sequence

  2. XR_001740338.1 RNA Sequence

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