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EIF3B eukaryotic translation initiation factor 3 subunit B [ Homo sapiens (human) ]

Gene ID: 8662, updated on 22-Mar-2020

Summary

Official Symbol
EIF3Bprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Bprovided by HGNC
Primary source
HGNC:HGNC:3280
See related
Ensembl:ENSG00000106263 MIM:603917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRT1; EIF3S9; EIF3-ETA; EIF3-P110; EIF3-P116
Expression
Ubiquitous expression in testis (RPKM 39.5), bone marrow (RPKM 32.1) and 25 other tissues See more
Orthologs

Genomic context

See EIF3B in Genome Data Viewer
Location:
7p22.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (2354086..2380745)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (2394474..2420380)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 6836 Neighboring gene sorting nexin 8 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 3 Neighboring gene kinesin family member pseudogene Neighboring gene neugrin, neurite outgrowth associated pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit B (EIF3B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with eIF3b in the cellullar cytoplasmic compartment PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit B (EIF3B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104664, MGC131875

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
molecular adaptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
 
regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral translational termination-reinitiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation initiation factor 3 complex, eIF3m IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit B
Names
eukaryotic translation initiation factor 3 subunit 9
eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)
eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa
prt1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037283.2NP_001032360.1  eukaryotic translation initiation factor 3 subunit B isoform 1

    See identical proteins and their annotated locations for NP_001032360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC004971, BQ045103, U78525
    Consensus CDS
    CCDS5332.1
    UniProtKB/Swiss-Prot
    P55884
    UniProtKB/TrEMBL
    A0A024R821
    Related
    ENSP00000354125.4, ENST00000360876.9
    Conserved Domains (4) summary
    cd12278
    Location:184264
    RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
    sd00039
    Location:376423
    7WD40; WD40 repeat [structural motif]
    cl25541
    Location:305805
    eIF2A; Eukaryotic translation initiation factor eIF2A
    cl26386
    Location:4161
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. NM_001362791.2NP_001349720.1  eukaryotic translation initiation factor 3 subunit B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC004971, BC009986, U78525
    Consensus CDS
    CCDS5332.1
    Conserved Domains (4) summary
    cd12278
    Location:184264
    RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
    sd00039
    Location:376423
    7WD40; WD40 repeat [structural motif]
    cl25541
    Location:305805
    eIF2A; Eukaryotic translation initiation factor eIF2A
    cl26386
    Location:4161
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  3. NM_001362792.2NP_001349721.1  eukaryotic translation initiation factor 3 subunit B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004840, AC004971, BQ045103, DA781713
    Conserved Domains (2) summary
    sd00039
    Location:104151
    7WD40; WD40 repeat [structural motif]
    cl25541
    Location:33533
    eIF2A; Eukaryotic translation initiation factor eIF2A
  4. NM_001362793.2NP_001349722.1  eukaryotic translation initiation factor 3 subunit B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004840, AC004971, BQ045103, DA781713
    Conserved Domains (2) summary
    sd00039
    Location:104151
    7WD40; WD40 repeat [structural motif]
    cl25541
    Location:33533
    eIF2A; Eukaryotic translation initiation factor eIF2A
  5. NM_003751.4NP_003742.2  eukaryotic translation initiation factor 3 subunit B isoform 1

    See identical proteins and their annotated locations for NP_003742.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC004971, BQ015102, U78525
    Consensus CDS
    CCDS5332.1
    UniProtKB/Swiss-Prot
    P55884
    UniProtKB/TrEMBL
    A0A024R821
    Related
    ENSP00000380206.2, ENST00000397011.2
    Conserved Domains (4) summary
    cd12278
    Location:184264
    RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
    sd00039
    Location:376423
    7WD40; WD40 repeat [structural motif]
    cl25541
    Location:305805
    eIF2A; Eukaryotic translation initiation factor eIF2A
    cl26386
    Location:4161
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    2354086..2380745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515599.1XP_011513901.1  eukaryotic translation initiation factor 3 subunit B isoform X1

    See identical proteins and their annotated locations for XP_011513901.1

    UniProtKB/Swiss-Prot
    P55884
    UniProtKB/TrEMBL
    A0A024R821
    Conserved Domains (4) summary
    cd12278
    Location:184264
    RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
    sd00039
    Location:376423
    7WD40; WD40 repeat [structural motif]
    cl25541
    Location:305805
    eIF2A; Eukaryotic translation initiation factor eIF2A
    cl26386
    Location:4161
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. XM_011515600.1XP_011513902.1  eukaryotic translation initiation factor 3 subunit B isoform X1

    See identical proteins and their annotated locations for XP_011513902.1

    UniProtKB/Swiss-Prot
    P55884
    UniProtKB/TrEMBL
    A0A024R821
    Conserved Domains (4) summary
    cd12278
    Location:184264
    RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
    sd00039
    Location:376423
    7WD40; WD40 repeat [structural motif]
    cl25541
    Location:305805
    eIF2A; Eukaryotic translation initiation factor eIF2A
    cl26386
    Location:4161
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  3. XM_011515601.1XP_011513903.1  eukaryotic translation initiation factor 3 subunit B isoform X2

    See identical proteins and their annotated locations for XP_011513903.1

    UniProtKB/TrEMBL
    A4D210
    Conserved Domains (5) summary
    COG5354
    Location:266766
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    cd12278
    Location:145225
    RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
    sd00039
    Location:337384
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:301441
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl03075
    Location:37137
    GrpE; nucleotide exchange factor GrpE
  4. XM_017012753.1XP_016868242.1  eukaryotic translation initiation factor 3 subunit B isoform X3

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