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EIF3A eukaryotic translation initiation factor 3 subunit A [ Homo sapiens (human) ]

Gene ID: 8661, updated on 5-Jul-2020

Summary

Official Symbol
EIF3Aprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Aprovided by HGNC
Primary source
HGNC:HGNC:3271
See related
Ensembl:ENSG00000107581 MIM:602039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3; P167; p180; p185; TIF32; EIF3S10; eIF3-p170; eIF3-theta
Expression
Ubiquitous expression in thyroid (RPKM 51.4), fat (RPKM 50.1) and 25 other tissues See more
Orthologs

Genomic context

See EIF3A in Genome Data Viewer
Location:
10q26.11
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (119033670..119080817, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120794541..120840959, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 36 Neighboring gene lactate dehydrogenase A pseudogene 5 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene Sharpr-MPRA regulatory region 2008 Neighboring gene DENN domain containing 10 Neighboring gene sideroflexin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
formation of cytoplasmic translation initiation complex IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
translation reinitiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral translational termination-reinitiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation initiation factor 3 complex, eIF3e IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 3 complex, eIF3m IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
multi-eIF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit A
Names
EIF3, p180 subunit
centrosomin homolog
cytoplasmic protein p167
eIF-3-theta
eIF3 p167
eIF3 p180
eIF3 p185
eukaryotic translation initiation factor 3 subunit 10
eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)
eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)
eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa
eukaryotic translation initiation factor 3, subunit 10, 170kD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003750.4NP_003741.1  eukaryotic translation initiation factor 3 subunit A

    See identical proteins and their annotated locations for NP_003741.1

    Status: VALIDATED

    Source sequence(s)
    AL157788, AL355598
    Consensus CDS
    CCDS7608.1
    UniProtKB/Swiss-Prot
    Q14152
    Related
    ENSP00000358140.3, ENST00000369144.8
    Conserved Domains (6) summary
    smart00088
    Location:426498
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam16214
    Location:9801099
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    cd16269
    Location:650661
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:643737
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:566685
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:516603
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    119033670..119080817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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