Format

Send to:

Choose Destination

EIF3A eukaryotic translation initiation factor 3 subunit A [ Homo sapiens (human) ]

Gene ID: 8661, updated on 21-Apr-2019

Summary

Official Symbol
EIF3Aprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Aprovided by HGNC
Primary source
HGNC:HGNC:3271
See related
Ensembl:ENSG00000107581 MIM:602039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3; P167; p180; p185; TIF32; EIF3S10; eIF3-p170; eIF3-theta
Expression
Ubiquitous expression in thyroid (RPKM 51.4), fat (RPKM 50.1) and 25 other tissues See more
Orthologs

Genomic context

See EIF3A in Genome Data Viewer
Location:
10q26.11
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (119033670..119080884, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120794541..120840959, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 36 Neighboring gene lactate dehydrogenase A pseudogene 5 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene Sharpr-MPRA regulatory region 2008 Neighboring gene family with sequence similarity 45 member A Neighboring gene sideroflexin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem (from REACTOME)
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystemThe cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF...
  • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
    Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
  • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
  • Formation of a pool of free 40S subunits, organism-specific biosystem (from REACTOME)
    Formation of a pool of free 40S subunits, organism-specific biosystemThe 80S ribosome dissociates into free 40S (small) and 60S (large) ribosomal subunits. Each ribosomal subunit is constituted by several individual ribosomal proteins and rRNA.
  • Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem (from REACTOME)
    Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystemBinding of the methionyl-tRNA initiator to the active eIF2:GTP complex results in the formation of the ternary complex. Subsequently, this Met-tRNAi:eIF2:GTP (ternary) complex binds to the complex fo...
  • GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
    GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemHydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
    IL2 signaling events mediated by PI3K, organism-specific biosystem
    IL2 signaling events mediated by PI3K
  • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
    L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
    Ribosomal scanning and start codon recognition, organism-specific biosystemThe 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the initiation codon and forms a 48S complex, in which the initiation codon is base paired to the anticodon o...
  • Translation, organism-specific biosystem (from REACTOME)
    Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
  • Translation Factors, organism-specific biosystem (from WikiPathways)
    Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
  • Translation initiation complex formation, organism-specific biosystem (from REACTOME)
    Translation initiation complex formation, organism-specific biosystemThe translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. e...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit A
Names
EIF3, p180 subunit
centrosomin homolog
cytoplasmic protein p167
eIF-3-theta
eIF3 p167
eIF3 p180
eIF3 p185
eukaryotic translation initiation factor 3 subunit 10
eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)
eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)
eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa
eukaryotic translation initiation factor 3, subunit 10, 170kD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003750.4NP_003741.1  eukaryotic translation initiation factor 3 subunit A

    See identical proteins and their annotated locations for NP_003741.1

    Status: VALIDATED

    Source sequence(s)
    AL157788, AL355598
    Consensus CDS
    CCDS7608.1
    UniProtKB/Swiss-Prot
    Q14152
    Related
    ENSP00000358140.3, ENST00000369144.8
    Conserved Domains (6) summary
    smart00088
    Location:426498
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam16214
    Location:9801099
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    cd16269
    Location:650661
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:643737
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:566685
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:516603
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    119033670..119080884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center