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IRS2 insulin receptor substrate 2 [ Homo sapiens (human) ]

Gene ID: 8660, updated on 5-Jul-2025
Official Symbol
IRS2provided by HGNC
Official Full Name
insulin receptor substrate 2provided by HGNC
Primary source
HGNC:HGNC:6126
See related
Ensembl:ENSG00000185950 MIM:600797; AllianceGenome:HGNC:6126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRS-2
Summary
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 24.6), fat (RPKM 23.1) and 23 other tissues See more
Orthologs
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See IRS2 in Genome Data Viewer
Location:
13q34
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (109752695..109786583, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (108981231..109015226, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (110405042..110438930, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903210 Neighboring gene uncharacterized LOC101927627 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:110317890-110319089 Neighboring gene Sharpr-MPRA regulatory region 15042 Neighboring gene NANOG hESC enhancer GRCh37_chr13:110364549-110365058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:110385669-110386170 Neighboring gene long intergenic non-protein coding RNA 676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:110390318-110390818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:110390819-110391319 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:110434285-110434851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:110437437-110438066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5499 Neighboring gene WAS/WASL-interacting protein family member 1-like Neighboring gene uncharacterized LOC105370360 Neighboring gene Sharpr-MPRA regulatory region 11013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:110460038-110460538

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to endothelin IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid homeostasis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mammary gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of long-chain fatty acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of D-glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycogen biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
insulin receptor substrate 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008154.1 RefSeqGene

    Range
    4985..38873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003749.3NP_003740.2  insulin receptor substrate 2

    See identical proteins and their annotated locations for NP_003740.2

    Status: REVIEWED

    Source sequence(s)
    AB050954, AF073310, AF161416, AF385933, AL162497, BC026044, CA416129, CA952668
    Consensus CDS
    CCDS9510.1
    UniProtKB/Swiss-Prot
    Q96RR2, Q9BZG0, Q9Y4H2, Q9Y6I5
    UniProtKB/TrEMBL
    Q96RG4
    Related
    ENSP00000365016.3, ENST00000375856.5
    Conserved Domains (3) summary
    cd01204
    Location:194297
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:31147
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:31144
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    109752695..109786583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    108981231..109015226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)