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IRS2 insulin receptor substrate 2 [ Homo sapiens (human) ]

Gene ID: 8660, updated on 2-Mar-2021

Summary

Official Symbol
IRS2provided by HGNC
Official Full Name
insulin receptor substrate 2provided by HGNC
Primary source
HGNC:HGNC:6126
See related
Ensembl:ENSG00000185950 MIM:600797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRS-2
Summary
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 24.6), fat (RPKM 23.1) and 23 other tissues See more
Orthologs
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Genomic context

See IRS2 in Genome Data Viewer
Location:
13q34
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (109752695..109786583, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (110405042..110438930, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927627 Neighboring gene long intergenic non-protein coding RNA 676 Neighboring gene uncharacterized LOC105370360 Neighboring gene Sharpr-MPRA regulatory region 11013 Neighboring gene RN7SK pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-7-mediated signaling pathway TAS
Traceable Author Statement
more info
 
lipid homeostasis TAS
Traceable Author Statement
more info
PubMed 
mammary gland development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of long-chain fatty acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
positive regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Ras protein signal transduction TAS
Traceable Author Statement
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycogen biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
insulin receptor substrate 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008154.1 RefSeqGene

    Range
    4985..38873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003749.3NP_003740.2  insulin receptor substrate 2

    See identical proteins and their annotated locations for NP_003740.2

    Status: REVIEWED

    Source sequence(s)
    AB050954, AF073310, AF161416, AF385933, AL162497, BC026044, CA416129, CA952668
    Consensus CDS
    CCDS9510.1
    UniProtKB/Swiss-Prot
    Q9Y4H2
    UniProtKB/TrEMBL
    Q9P084
    Related
    ENSP00000365016.3, ENST00000375856.5
    Conserved Domains (3) summary
    cd01204
    Location:194297
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:31147
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:31144
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    109752695..109786583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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