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Irs2 insulin receptor substrate 2 [ Mus musculus (house mouse) ]

Gene ID: 384783, updated on 5-Jan-2023

Summary

Official Symbol
Irs2provided by MGI
Official Full Name
insulin receptor substrate 2provided by MGI
Primary source
MGI:MGI:109334
See related
Ensembl:ENSMUSG00000038894 AllianceGenome:MGI:109334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irs-2
Summary
Enables phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of B cell apoptotic process; positive regulation of B cell proliferation; and positive regulation of insulin secretion. Acts upstream of or within several processes, including animal organ development; insulin receptor signaling pathway; and positive regulation of mesenchymal cell proliferation. Located in cytosol and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including brain ventricular layer; hindlimb digit skin; jaw; metanephros; and thymus primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 23.9), mammary gland adult (RPKM 19.4) and 28 other tissues See more
Orthologs
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Genomic context

See Irs2 in Genome Data Viewer
Location:
8 A1.1; 8 5.35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11034681..11058929, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (10984681..11008929, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3930402G23 gene Neighboring gene predicted gene, 32594 Neighboring gene RIKEN cDNA 9530052E02 gene Neighboring gene predicted gene 44717 Neighboring gene predicted gene 15418 Neighboring gene collagen, type IV, alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of type B pancreatic cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to glucose IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of type B pancreatic cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin receptor substrate 2
Names
4PS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081212.2NP_001074681.1  insulin receptor substrate 2

    See identical proteins and their annotated locations for NP_001074681.1

    Status: VALIDATED

    Source sequence(s)
    AC113484, AC138677
    Consensus CDS
    CCDS52477.1
    UniProtKB/Swiss-Prot
    B9EJW3, P81122
    Related
    ENSMUSP00000038514.7, ENSMUST00000040514.8
    Conserved Domains (3) summary
    cd01204
    Location:191294
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:31143
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:31143
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    11034681..11058929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)