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DYNLL1 dynein light chain LC8-type 1 [ Homo sapiens (human) ]

Gene ID: 8655, updated on 4-Apr-2021

Summary

Official Symbol
DYNLL1provided by HGNC
Official Full Name
dynein light chain LC8-type 1provided by HGNC
Primary source
HGNC:HGNC:15476
See related
Ensembl:ENSG00000088986 MIM:601562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1
Summary
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Annotation information
Note: DLC1 (Gene ID: 10395) and DYNLL1 (Gene ID: 8655) share the DLC1 symbol/alias in common. DLC1 is sometimes used as an alternative name for dynein light chain LC8-type 1 (DYNLL1), which can be confused with the official symbol for DLC1 Rho GTPase activating protein (DLC1). [05 Jul 2018]
Expression
Ubiquitous expression in brain (RPKM 141.7), esophagus (RPKM 133.4) and 25 other tissues See more
Orthologs
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Genomic context

See DYNLL1 in Genome Data Viewer
Location:
12q24.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (120469842..120498493)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120907645..120936296)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 52 Neighboring gene glutamyl-tRNA amidotransferase subunit C Neighboring gene serine and arginine rich splicing factor 9 Neighboring gene uncharacterized LOC107987181 Neighboring gene negative regulator of antiviral response Neighboring gene coenzyme Q5, methyltransferase Neighboring gene ribosomal protein L29 pseudogene 24 Neighboring gene ring finger protein 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dynein light chain 1 (DYNLL1) by shRNA inhibits HIV-1 replication in C8166T cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with DNCL1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
capsid gag Knockdown of DYNLL1 by shRNA leads to reduced levels of particulate CA in HIV-1-infected cells, suggesting that DYNLL1 plays an important role in CA uncoating PubMed
integrase gag-pol HIV-1 IN mutant Q53A/Q252A is greatly impaired in its ability to interact with PL-DYNLL1 compared to the wild-type PubMed
gag-pol Amino acid residues 50 to 117 and 230 to 288 in HIV-1 IN are essential for interaction with DYNLL1, and two motifs 52GQVD56 and 250VIQD253 in IN closely resemble the consensus sequence for DYNLL1 interaction PubMed
gag-pol The requirement of DYNLL1 for HIV-1 reverse transcription is HIV-1 IN dependent in cells PubMed
gag-pol Co-immunoprecipitation assay demonstrates the direct interaction of HIV-1 IN with DYNLL1 in HIV-1-infected C8166 CD4+ T cells PubMed
reverse transcriptase gag-pol The requirement of DYNLL1 for HIV-1 reverse transcription is HIV-1 IN dependent in cells PubMed
gag-pol Knockdown of DYNLL1 by shRNA results in reduced levels of total HIV-1 DNA and 2-LTR circle DNA compared to control cells, suggesting that DYNLL1 is specifically involved in efficient HIV-1 reverse transcription at early times postinfection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126137, MGC126138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
intraciliary retrograde transport IEA
Inferred from Electronic Annotation
more info
 
intraciliary transport involved in cilium assembly TAS
Traceable Author Statement
more info
 
macroautophagy TAS
Traceable Author Statement
more info
 
motile cilium assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development HEP PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary tip TAS
Traceable Author Statement
more info
 
cilium TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dynein light chain 1, cytoplasmic
Names
8 kDa dynein light chain
cytoplasmic dynein light polypeptide
dynein, cytoplasmic, light polypeptide 1
protein inhibitor of neuronal nitric oxide synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037494.2NP_001032583.1  dynein light chain 1, cytoplasmic

    See identical proteins and their annotated locations for NP_001032583.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. . Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL021546, BG474448, BI491360, CB992195, CD678447
    Consensus CDS
    CCDS9200.1
    UniProtKB/Swiss-Prot
    P63167
    UniProtKB/TrEMBL
    Q6FGH9
    Related
    ENSP00000376297.2, ENST00000392509.6
    Conserved Domains (1) summary
    cl41776
    Location:588
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily
  2. NM_001037495.2NP_001032584.1  dynein light chain 1, cytoplasmic

    See identical proteins and their annotated locations for NP_001032584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR including an alternate, downstream transcription initiation site. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC104244, BM817665, CD678447
    Consensus CDS
    CCDS9200.1
    UniProtKB/Swiss-Prot
    P63167
    UniProtKB/TrEMBL
    Q6FGH9
    Related
    ENSP00000376296.2, ENST00000392508.2
    Conserved Domains (1) summary
    cl41776
    Location:588
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily
  3. NM_003746.3NP_003737.1  dynein light chain 1, cytoplasmic

    See identical proteins and their annotated locations for NP_003737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR, including an alternate, downstream transcription initiation site. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC063943, BU598428
    Consensus CDS
    CCDS9200.1
    UniProtKB/Swiss-Prot
    P63167
    UniProtKB/TrEMBL
    Q6FGH9
    Related
    ENSP00000242577.6, ENST00000242577.11
    Conserved Domains (1) summary
    cl41776
    Location:588
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    120469842..120498493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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