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Dynll1 dynein light chain LC8-type 1 [ Mus musculus (house mouse) ]

Gene ID: 56455, updated on 5-Jan-2023

Summary

Official Symbol
Dynll1provided by MGI
Official Full Name
dynein light chain LC8-type 1provided by MGI
Primary source
MGI:MGI:1861457
See related
Ensembl:ENSMUSG00000009013 AllianceGenome:MGI:1861457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pin; Dlc8; Dnclc1
Summary
Enables dynein intermediate chain binding activity; protein C-terminus binding activity; and protein domain specific binding activity. Acts upstream of or within intraciliary retrograde transport; motile cilium assembly; and positive regulation of non-motile cilium assembly. Located in cytoskeleton; cytosol; and membrane. Part of cytoplasmic dynein complex. Is expressed in several structures, including central nervous system; heart; liver; lung; and sensory organ. Orthologous to human DYNLL1 (dynein light chain LC8-type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 89.2), CNS E18 (RPKM 88.6) and 25 other tissues See more
Orthologs
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Genomic context

See Dynll1 in Genome Data Viewer
Location:
5; 5 F
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115435169..115439049, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115297110..115300990, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 10 Neighboring gene coenzyme Q5 methyltransferase Neighboring gene predicted gene 13830 Neighboring gene serine and arginine-rich splicing factor 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein intermediate chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase regulator activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intraciliary retrograde transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mitocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of non-motile cilium assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in axon cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytoplasmic dynein complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cytoplasmic dynein complex ISA
Inferred from Sequence Alignment
more info
PubMed 
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of microtubule associated complex IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynein light chain 1, cytoplasmic
Names
8 kDa dynein light chain
8kD LC
8kDa LC
dynein, cytoplasmic, light chain 1
dynein, cytoplasmic, light peptide
mPIN
protein inhibitor of neuronal nitric oxide synthase
protein inhibitor of nitric oxide synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019682.5NP_062656.3  dynein light chain 1, cytoplasmic

    See identical proteins and their annotated locations for NP_062656.3

    Status: VALIDATED

    Source sequence(s)
    AC145070
    Consensus CDS
    CCDS39227.1
    UniProtKB/Swiss-Prot
    P63168, Q3UGE7
    UniProtKB/TrEMBL
    A0A6P5PQY5
    Related
    ENSMUSP00000009157.4, ENSMUST00000009157.4
    Conserved Domains (1) summary
    cd21452
    Location:588
    DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115435169..115439049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)