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PDE8B phosphodiesterase 8B [ Homo sapiens (human) ]

Gene ID: 8622, updated on 8-Jul-2021

Summary

Official Symbol
PDE8Bprovided by HGNC
Official Full Name
phosphodiesterase 8Bprovided by HGNC
Primary source
HGNC:HGNC:8794
See related
Ensembl:ENSG00000113231 Ensembl:ENSG00000284762 MIM:603390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADSD; PPNAD3
Summary
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Expression
Biased expression in thyroid (RPKM 82.4), brain (RPKM 15.1) and 5 other tissues See more
Orthologs
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Genomic context

See PDE8B in Genome Data Viewer
Location:
5q13.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (77180304..77428256)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76476129..76724081)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ZBED3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 15273 Neighboring gene high mobility group box 1 pseudogene 35 Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 1 Neighboring gene WD repeat domain 41 Neighboring gene ribosomal protein S2 pseudogene 24 Neighboring gene ribosomal protein L7 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
GeneReviews: Not available
Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.
GeneReviews: Not available
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
GeneReviews: Not available
Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function.
GeneReviews: Not available
Novel associations for hypothyroidism include known autoimmune risk loci.
GeneReviews: Not available
Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.
GeneReviews: Not available
Pigmented nodular adrenocortical disease, primary, 3
MedGen: C3280094 OMIM: 614190 GeneReviews: Not available
Compare labs
Striatal degeneration, autosomal dominant 1
MedGen: C4310808 OMIM: 609161 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Names
3',5' cyclic nucleotide phosphodiesterase 8B
cell proliferation-inducing gene 22 protein
NP_001025022.1
NP_001025023.1
NP_001025024.1
NP_001025025.1
NP_001336677.1
NP_001336678.1
NP_001336679.1
NP_001336680.1
NP_001336681.1
NP_001336682.1
NP_001362991.1
NP_001362992.1
NP_001362993.1
NP_001362994.1
NP_001362995.1
NP_001362996.1
NP_001362997.1
NP_001362998.1
NP_001362999.1
NP_001363000.1
NP_001363001.1
NP_001363002.1
NP_001363003.1
NP_001363004.1
NP_003710.1
XP_006714789.1
XP_011542001.1
XP_011542002.1
XP_011542006.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023364.2 RefSeqGene

    Range
    35429..254556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029851.4NP_001025022.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3

    See identical proteins and their annotated locations for NP_001025022.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS34192.1
    UniProtKB/Swiss-Prot
    O95263
    UniProtKB/TrEMBL
    B3KN77
    Related
    ENSP00000330428.3, ENST00000346042.7
    Conserved Domains (3) summary
    PHA02597
    Location:158311
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:517764
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
  2. NM_001029852.4NP_001025023.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 5

    See identical proteins and their annotated locations for NP_001025023.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KF457931
    Consensus CDS
    CCDS34190.1
    UniProtKB/Swiss-Prot
    O95263
    UniProtKB/TrEMBL
    B3KN77
    Related
    ENSP00000331336.4, ENST00000333194.8
    Conserved Domains (4) summary
    cd00130
    Location:284376
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:559806
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:279377
    PAS_9; PAS domain
  3. NM_001029853.4NP_001025024.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 4

    See identical proteins and their annotated locations for NP_001025024.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS34193.1
    UniProtKB/Swiss-Prot
    O95263
    UniProtKB/TrEMBL
    B3KN77
    Related
    ENSP00000345646.4, ENST00000342343.8
    Conserved Domains (4) summary
    cd00130
    Location:264356
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:594841
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:259357
    PAS_9; PAS domain
  4. NM_001029854.4NP_001025025.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 2

    See identical proteins and their annotated locations for NP_001025025.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS34191.1
    UniProtKB/Swiss-Prot
    O95263
    UniProtKB/TrEMBL
    B3KN77
    Related
    ENSP00000345446.3, ENST00000340978.7
    Conserved Domains (2) summary
    pfam00233
    Location:567814
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
  5. NM_001349748.3NP_001336677.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:613860
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:279376
    PAS_9; PAS domain
  6. NM_001349749.3NP_001336678.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:635882
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:301398
    PAS_9; PAS domain
  7. NM_001349750.3NP_001336679.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (2) summary
    pfam00233
    Location:534781
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:200297
    PAS_9; PAS domain
  8. NM_001349751.3NP_001336680.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:613805
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:279376
    PAS_9; PAS domain
  9. NM_001349752.3NP_001336681.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    COG2202
    Location:46273
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:512759
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:178275
    PAS_9; PAS domain
  10. NM_001349753.2NP_001336682.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS87307.1
    Conserved Domains (3) summary
    COG2202
    Location:24251
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156253
    PAS_9; PAS domain
  11. NM_001376062.1NP_001362991.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    COG2202
    Location:47274
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:513760
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:179276
    PAS_9; PAS domain
  12. NM_001376063.1NP_001362992.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (4) summary
    COG2202
    Location:148368
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:611858
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:280373
    PAS_9; PAS domain
  13. NM_001376064.1NP_001362993.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (4) summary
    COG2202
    Location:148317
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:564811
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:280333
    PAS_9; PAS domain
  14. NM_001376065.1NP_001362994.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    PHA02597
    Location:157310
    30.2; hypothetical protein; Provisional
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:516763
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  15. NM_001376066.1NP_001362995.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    COG2202
    Location:27254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:493740
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:159256
    PAS_9; PAS domain
  16. NM_001376067.1NP_001362996.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Related
    ENSP00000493971.1, ENST00000646262.1
    Conserved Domains (3) summary
    COG2202
    Location:24251
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156253
    PAS_9; PAS domain
  17. NM_001376068.1NP_001362997.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    COG2202
    Location:24251
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156253
    PAS_9; PAS domain
  18. NM_001376069.1NP_001362998.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (1) summary
    pfam00233
    Location:486733
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  19. NM_001376070.1NP_001362999.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (1) summary
    pfam00233
    Location:466713
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  20. NM_001376071.1NP_001363000.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (1) summary
    pfam00233
    Location:465712
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  21. NM_001376072.1NP_001363001.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    COG2202
    Location:47274
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:513705
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:179276
    PAS_9; PAS domain
  22. NM_001376073.1NP_001363002.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (2) summary
    PHA02597
    Location:57210
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:416663
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  23. NM_001376074.1NP_001363003.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (2) summary
    PHA02597
    Location:37190
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:396643
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  24. NM_001376075.1NP_001363004.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (2) summary
    PHA02597
    Location:34187
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:393640
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  25. NM_003719.5NP_003710.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1

    See identical proteins and their annotated locations for NP_003710.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS4037.1
    UniProtKB/Swiss-Prot
    O95263
    UniProtKB/TrEMBL
    B3KN77
    Related
    ENSP00000264917.6, ENST00000264917.10
    Conserved Domains (4) summary
    cd00130
    Location:284376
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:614861
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:279377
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    77180304..77428256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543699.3XP_011542001.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

    Conserved Domains (4) summary
    cd00130
    Location:305397
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:635827
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:300398
    PAS_9; PAS domain
  2. XM_011543700.3XP_011542002.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3

    Conserved Domains (3) summary
    PHA02597
    Location:179332
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:538785
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
  3. XM_006714726.3XP_006714789.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

    Conserved Domains (4) summary
    cd00130
    Location:304396
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:634881
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:299397
    PAS_9; PAS domain
  4. XM_011543704.2XP_011542006.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X10

    See identical proteins and their annotated locations for XP_011542006.1

    Conserved Domains (3) summary
    cd00130
    Location:46138
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:376623
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:41139
    PAS_9; PAS domain
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